Results 71 to 80 of about 36,272,883 (300)

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

open access: yesMolecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic   +10 more
wiley   +1 more source

Basic connotation, core problems and key technologies of wisdom mine

open access: yesGong-kuang zidonghua, 2019
Basic connotations of wisdom mine were summarized, which were having active perception ability, automatic analysis ability and quick processing ability, digital mine was the foundation and support of wisdom mine, while unmanned mine was the advanced ...
LUO Xiangyu, LI Jianan, LANG Ding
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim   +17 more
wiley   +1 more source

Evolution of smart mine construction and its development tendency

open access: yesGong-kuang zidonghua, 2019
Combining with construction experiences and lessons of integrated automation to smart mine in each coal mine, smart mine construction was summarized, and it was emphasized that smart mine construction was an evolution process step by step.
LI Xiaosi, MA Jianmin, WANG Yingying
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

open access: yesFEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli   +8 more
wiley   +1 more source

Doctor mine, Gunnison County, Colorado

open access: yes, 2022
Mine report no. 1138.Includes maps.Typescript (carbon copy).Doctor mine, Gunnison district, Colorado / W.H. Cary -- The Doctor mine / H.L. Brown -- Doctor mine, Gunnison County, Colorado / M.W.
Brown, H. L.   +2 more
core  

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

open access: yesFEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee   +3 more
wiley   +1 more source

Digital Data Mining

open access: yes
Abstract Recreational fishers who interact with internet-connected and smart devices generate large volumes of digital data that can be mined to gain valuable and often unique insight into recreational fisher behaviours. Common sources of digital data include general online activity (e.g., searches, page views), social media (e.g ...
Paul Venturelli   +13 more
openaire   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

open access: yesFEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Properties of the Bassick gold mine Co.

open access: yes, 2022
Scale approximately 1:720.Photocopy.Blueline print.Photographic copy of a map showing claims in T. 22 S., R.

core  

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