Results 151 to 160 of about 18,538 (254)

Conformation‐Selective Binding Domains of Intramolecular Chemically Induced Protein Dimerisation Systems

Angewandte Chemie, EarlyView.
Intramolecular chemically induced dimerisation transforms FK506‐ and cyclosporine A‐responsive protein pairs into high‐affinity pseudo‐allosteric switches. Holo‐selective binders isolated by mRNA display convert these switches into gain‐of‐signal biosensors and ultrasensitive ELISAs, enabling direct quantification of both immunosuppressants in ...
Zhenling Cui, Zhong Guo, Yi Jin Liew, Alessandro T. Caputo, Maria M. Fiorito, Cagla Ergun Ayva, Roxane Mutschler, Mayra Barrios Leguarca, Sophia Newton, Gia Nghi Lam, Robert Speight, Brett McWhinney, Yanulla Essie Georges, Carel Pretorius, Jacobus P.J. Ungerer, Kirill Alexandrov   +15 more
wiley   +2 more sources

Empowering Parents of Adolescents at Elevated Risk of Suicide: Co-Designing an Adaptation to a Coach-Assisted, Digital Parenting Intervention. [PDF]

Eur J Investig Health Psychol Educ
Cao A, Wu L, Melvin G, Cardamone-Breen M, Broomfield G, Seguin J, Salvaris C, Xie J, Basur D, Bartindale T, McNaney R, Olivier P, Yap MBH.   +12 more
europepmc   +1 more source

1,2‐propanediol reformulation improves tribromoethanol safety and reveals pontine GABRA1 enrichment as a candidate mechanistic correlate of anesthesia

Animal Models and Experimental Medicine, EarlyView.
This study develops a reformulated tribromoethanol (TBE) anesthetic using 1,2‐propanediol as a solvent to overcome solvent‐related toxicity. The novel formulation demonstrates, cardiovascular stability, and survival in prolonged protocols. It provides potent, dose‐dependent anesthesia without strain or sex differences.
Xia Li, Yanming Chen, Xinyi Xiao, Guoheng Xu   +3 more
wiley   +1 more source

Visualization, Interaction and Evaluation, and Memory: How Social Media Parenting Practices Mediate the Relationship Between Authoritative Parenting and Mental Health of Young Adult

Psychology Research and Behavior Management
Ruixia Han1,2 1School of Journalism and Communication, Shanghai International Studies University, Shanghai, 201620, People’s Republic of China; 2School of Media and Communication, Shanghai Jiao Tong University, Shanghai, 200240, People’s Republic of ...
Han R
doaj  

Institutionalizing Digital Parenting Programs in Low Resource Settings in China: Comparative Case Study of Health Care and Education Sectors Using the RE-AIM Framework. [PDF]

J Med Internet Res
Shi X, Ruan R, Qie Y, Lachman JM, Zhong N, Fang Z.   +5 more
europepmc   +1 more source

Complete Pathway Refactoring and Combinatorial Biosynthesis of Anthracyclines for Modulation of Histone Eviction and DNA Damage Bioactivities

Angewandte Chemie, EarlyView.
A synthetic biology platform was established for the complete refactoring of complex anthracycline biosynthetic pathways in Streptomyces coelicolor using standardized, chemically synthetic DNA parts. This modular construction enabled streamlined combinatorial biosynthesis, yielding novel analogs that decouple DNA damage from chromatin damage (histone ...
Rongbin Wang, Heli Tirkkonen, Sabina Y. van der Zanden, Larissa Ponomareva, Isaline Fagon, Leslie Fève, Kendall Paige, Courtney L. Brown, Nora Schwartz, Jacob Hecht, Jennifer Nguyen, Jon S. Thorson, Jacques Neefjes, S. Eric Nybo, Khaled A. Shaaban, Mikko Metsä‐Ketelä   +15 more
wiley   +1 more source

Examining the effect of digital parenting attitudes on digital game addiction. [PDF]

Rev Esc Enferm USP
Kabadayı H, Eyimaya AÖ.
europepmc   +1 more source

Does human support add value to persuasive design-based digital mental health interventions? A propensity score matching study of a digital parenting program. [PDF]

Front Digit Health
Saar CR, Brandes O, Baumel A.
europepmc   +1 more source

Polyproline: A Synthetic Polypeptide With Unique Properties

Angewandte Chemie, EarlyView.
Poly‐L‐proline is a unique polypeptide distinguished by its well‐defined secondary structures and unusual thermal behavior. This mini review highlights recent advances in the synthesis of poly‐L‐proline by N‐carboxyanhydride (NCA) polymerization, the formation of structurally defined architectures and nanostructures, and emerging strategies that ...
Rosanna Le Scouarnec, Josué M. Galindo, Colin Bonduelle, Andreas Heise   +3 more
wiley   +1 more source

A Digital Parenting Intervention With Intimate Partner Violence Prevention Content: Quantitative Pre-Post Pilot Study. [PDF]

JMIR Form Res
Schafer M, Lachman J, Zinser P, Calderón Alfaro FA, Han Q, Facciola C, Clements L, Gardner F, Haupt Ronnie G, Sheil R.   +9 more
europepmc   +1 more source