Results 201 to 210 of about 293,837 (250)

Tumor lactate metabolism shapes immune suppression and therapeutic resistance revealed by integrative multi-omics and digital pathology. [PDF]

Front Immunol
Feng B, Zhu Y, Zhang Z, Wang Y, Schuler PJ, Hess J.   +5 more
europepmc   +1 more source

CD31+ Cell Enrichment Enhances Therapeutic Effects of Stromal Vascular Fraction in Experimental Primary Osteoarthritis: A Preclinical Study in the Dunkin Hartley Guinea Pig Model

Advanced Science, EarlyView.
Both SVF and CD31+ SVF improve spontaneous osteoarthritis, but CD31+ enrichment refines the therapeutic profile rather than broadly enhancing all effects. More distinct benefits are observed in extracellular matrix remodeling, osteochondral integrity, and subchondral/trabecular bone preservation, supporting CD31+‐enriched SVF as a biologically enhanced
Sijia Zhou, Tobias Winkler, Bin Chen, Marta Grzeski, Yilong Yang, Florian N. Fleckenstein, Dominik Geisel, Alexander Hildebrandt, Daniela Aschenbrenner, Marie Agatha Mohn, Benjamin Claass, January Weiner 3rd, Sven Geissler, Georg N. Duda, Søren P. Sheikh, Oliver Klein, Tazio Maleitzke   +16 more
wiley   +1 more source

Deep learning for digital pathology: A critical overview of methodological framework. [PDF]

J Pathol Inform
Rad MS, Huang JV, Hosseini MM, Choudhary R, Siezen H, Akabari R, Jamaspishvili T, El-Zammar O, Patel PG, Carello SJ, Nasr MR, Rodd B.   +11 more
europepmc   +1 more source

Neuron‐Derived MIF Engages VCAM1 to Fuel a Self‐Amplifying CXCL8 Loop That Drives Perineural Invasion and Metastasis in Gastric Cancer

Advanced Science, EarlyView.
Neuron‐derived MIF binds VCAM1 on gastric cancer cells and activates ERK/STAT3 signaling, leading to CXCL8 transcription and secretion. Tumor‐derived CXCL8 subsequently stimulates neuronal CXCR2 to enhance MIF production, establishing a self‐amplifying MIF–VCAM1–CXCL8 positive‐feedback loop that promotes perineural invasion, tumor progression, and ...
Xunjun Li, Zhongya Zhai, Haiyi Yu, Renjie Qiu, Fengyu Li, Luxi Xiao, Boxi Huang, Huiying Liu, Jiayong He, Bowen Cai, Jiawen Chen, Jiang Yu, Guoxin Li, Tao Chen   +13 more
wiley   +1 more source

AI caption generation model for digital pathology of adenocarcinoma in endoscopic histopathology using multi-instance attention mechanisms. [PDF]

Sci Rep
Lee Y, Bai K, Kim YJ, Kim J, Kim KG.
europepmc   +1 more source

De Novo Designed Minibinders Targeting the GDF15–GFRAL Axis Reverse Cancer Cachexia and Restore Anti‐Tumor Immunity

Advanced Science, EarlyView.
Tumor‐derived GDF15 drives cancer cachexia and suppresses antitumor immunity. Here, de novo designed minibinders targeting the GDF15–GFRAL interface achieve picomolar affinity and potent pathway blockade. The minibinders alleviate cachexia, restore CD8+ T‐cell infiltration, enhance anti–PD‐1 responsiveness, and provide survival benefits across tumor ...
Haitao Wang, Tianzhen Hua, Meiling Wang, Bingbing Meng, Yue Zhang, Chengxu Jiang, Yunhe Gao, Hongqi Yang, Jian Bo   +8 more
wiley   +1 more source

From Slide to Insight: The Emerging Alliance of Digital Pathology and AI in Melanoma Diagnostics. [PDF]

Cancers (Basel)
Venturi F, Veronesi G, Gualandi A, Magnaterra E, Scotti B, Sotiri I, Baraldi C, Alessandrini AM, Veneziano L, Vaccari S, Cama EM, Tassone D, Corti B, Dika E.   +13 more
europepmc   +1 more source

Digital Pathology—The Big Picture

Human Pathology, 2000
openaire   +2 more sources

Digital pathology in tau research: A comparison of QuPath and HALO. [PDF]

J Neuropathol Exp Neurol
Gonzalez AD, Wadop YN, Danner B, Clarke KM, Dopler MB, Ghaseminejad-Bandpey A, Babu S, Parker-Garza J, Corbett C, Alhneif M, Keating M, Bieniek KF, Maestre GE, Seshadri S, Etemadmoghadam S, Fongang B, Flanagan ME.   +16 more
europepmc   +1 more source

Spatial SRY-Box Transcription Factor 2 Expression and Stemness-Associated Markers Refine Risk Stratification in Barrett's Esophagus: A Digital Pathology Study of 217 Patients. [PDF]

J Clin Med Res
Meshveliani P, Didava G, Tomadze G, Burkadze G, Kepuladze S.   +4 more
europepmc   +1 more source