Hyaluronic acid‐modified bimetallic peroxide nanocomposites (MgO2‐CuO2@HA) are designed for synergistic tumor therapy. The nanocomposites release Mg2+, H2O2, and Cu2+ in tumor cells, induce cuproptosis via Cu+‐mediated protein aggregation, and activate pyroptosis through caspase‐1/gasdermin D pathways for inducing immunogenic cell death, collectively ...
Guanting He +8 more
wiley +1 more source
AI-assisted sentinel lymph node examination and metastatic detection in breast cancer: the potential of ChatGPT for digital pathology research. [PDF]
Angelico G +14 more
europepmc +1 more source
Selective Targeting of Tip Endothelial Cells as a Therapeutic Strategy for Tumor Angiogenesis
Doppel protein is selectively expressed in tip endothelial cells within the tumor vasculature, where it promotes tip cell motility and stabilizes the tip cell phenotype. Targeting Doppel with monoclonal antibodies disrupts this stabilization, impairs angiogenic sprouting, and reduces tumor angiogenesis, offering a selective and druggable switch for ...
Byoungmo Kim +16 more
wiley +1 more source
Prognostic prediction in soft-tissue sarcomas using deep learning and digital pathology of tumor and margin areas. [PDF]
Michot A +15 more
europepmc +1 more source
Mid‐infrared optoacoustic microscopy (MiROM) acquires lipid‐ and protein‐ associated vibrational contrast in intact fat tissue without dyes, preserving native tissue architecture. Through lateral and axial segmentation, MiROM tracks intrinsic intracellular changes during postnatal remodeling. A quantitative spatial analysis tool (Q‐SAT) maps white‐ and
Myeongseop Kim +7 more
wiley +1 more source
Translational deep learning models for risk stratification to predict prognosis and immunotherapy response in gastric cancer using digital pathology. [PDF]
Nguyen MH +6 more
europepmc +1 more source
AI in Digital Pathology for Diffuse Large B-cell Lymphoma: A Systematic Review of Diagnosis and Classification. [PDF]
Torres Luna JD +6 more
europepmc +1 more source
Current Trends and Future Directions of Digital Pathology and Artificial Intelligence in Dermatopathology: A Scientometric-Based Review. [PDF]
Cocuz IG +9 more
europepmc +1 more source
Enhanced digital pathology image recognition via multi-attention mechanisms: the MACC-Net approach. [PDF]
Liu F +6 more
europepmc +1 more source

