Results 251 to 260 of about 43,201,948 (340)

α‐Synuclein Forms Distinct Micelle‐Like Assemblies at Low Ionic Strengths

Advanced Science, EarlyView.
At high ionic strength, α‐synuclein forms diverse assemblies, including oligomers, fibrils, and condensates. Here, we show that at low ionic strength, α‐synuclein adopts a distinct, low‐abundance assembly state. These assemblies maintain a constant size above a critical concentration and do not coalesce, suggesting a micelle‐like organization ...
Sophie Hertel, Soumik Ray, Federica Saraceno, Giacomo Nisini, Georgia Nasi, Thomas Oliver Mason, Antonin Kunka, Effrosyni Agrimaki, Dannie Juul Olesen, Francesco Simone Ruggeri, Alexander K. Buell   +10 more
wiley   +1 more source

The impact of tissue detection on diagnostic artificial intelligence algorithms in prostate digital pathology. [PDF]

Sci Rep
Boman SE, Mulliqi N, Blilie A, Ji X, Szolnoky K, Gudlaugsson E, Janssen EAM, Kjosavik SR, Asenjo J, Gambacorta M, Libretti P, Braun M, Kordek R, Łowicki R, Hotakainen K, Väre P, Pedersen BG, Sørensen KD, Ulhøi BP, Egevad L, Kartasalo K.   +20 more
europepmc   +1 more source

An Update on the Use of Artificial Intelligence in Digital Pathology for Oral Epithelial Dysplasia Research

Head and Neck Pathology
Shahd A. Alajaji, Zaid H. Khoury, Maryam Jessri, James J. Sciubba, Ahmed S. Sultan   +4 more
semanticscholar   +1 more source

Targeting the PHB2–ACSL3 Lipid‐Remodeling Axis Overcomes Cisplatin Resistance by Restoring Ferroptosis in Gastric Cancer

Advanced Science, EarlyView.
ABSTRACT Platinum‐based chemotherapy resistance remains a major obstacle in gastric cancer (GC) treatment. Through integrated transcriptomic profiling of cisplatin‐resistant xenografts and pharmacogenomic interrogation of the NCI‐60 dataset, we identified Prohibitin‐2 (PHB2) as a previously unrecognized determinant of chemoresistance.
Liang Xu, Wanying Xiang, Xinyue Wang, Yue Pan, Jing Gao, Jiezhen Yang, Yufei Wang, Zhipu Zhu, Man Tong, Lei Jin, Yan Ye   +10 more
wiley   +1 more source

Color Management in Digital Pathology

Analytical Cellular Pathology, 2014
W. Craig Revie, Mike Shires, Pete Jackson, David Brettle, Ravinder Cochrane, Darren Treanor   +5 more
doaj   +1 more source

WSI-Babel-Shark: A modular pipeline for robust metadata extraction from heterogeneous whole slide image labels in digital pathology. [PDF]

J Pathol Inform
Aliyari S, Legnar M, Blattgerste C, Jessen A, Thirukonda Subramanian Balakrishnan B, Englert N, Kaib PSJ, Sementsov M, Schwab C, Weis CA.   +9 more
europepmc   +1 more source

Generative models for color normalization in digital pathology and dermatology: Advancing the learning paradigm

Expert systems with applications
M. Salvi, Francesco Branciforti, Filippo Molinari, K. Meiburger   +3 more
semanticscholar   +1 more source

Tissue‐Agnostic Cellular Morphometric Biomarkers for Risk‐Adapted Management Across Gastrointestinal Precancerous Lesions and Cancers

Advanced Science, EarlyView.
An interpretable, unsupervised artificial intelligence framework identifies a 13‐cellular morphometric biomarker (CMB) signature from routine H&E whole‐slide images. Validated across 2,602 patients, the fixed signature generalizes across colorectal, gastric, and esophageal tissues without retraining, stratifies prognosis and precancerous lesion risk ...
Pin Wang, Chengfei Jiang, April W. Mao, Qi Sun, Yijun Lu, Jingjing Wei, Jamie L. Inman, Susan E. Celniker, Antoine M. Snijders, David W. Threadgill, Allan Balmain, Bo Hang, Hang Chang, Lei Wang, Jian‐Hua Mao   +14 more
wiley   +1 more source

CHST1 Drives Immunotherapy Resistance in Triple‐Negative Breast Cancer by Orchestrating an Immunosuppressive Microenvironment via the NKRF–CCL20–Macrophage Axis

Advanced Science, EarlyView.
Proposed model of CHST1‐associated immune remodeling in triple‐negative breast cancer. In CHST1‐low tumors, greater nuclear accumulation of NKRF is associated with repression of an NF‐κB‐related CCL20 transcriptional program and an immune‐inflamed microenvironment.
Shu‐Hao Jiang, Xiao‐Han Ying, Ruo‐Qing Wang, Qun Zhang, Li Chen, Zhi‐Ming Shao, Jun‐Jie Li   +6 more
wiley   +1 more source