Results 41 to 50 of about 330,826 (262)

Review of Some Popular Higher Educational Mathematics Course and Homework Platforms

open access: yesIssues and Trends in Learning Technologies
Digital course and homework platforms are popular within collegiate mathematics courses. The diversity of choices available to professors leaves them with the monumental task of sorting through the platforms to determine which is best for their class ...
Patricia Anderson, Scot Anderson
doaj   +2 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

1st International Workshop on Digital Platforms and Resources for Access to Literary Heritage (DIPRAL 2022)

open access: yes, 2022
This document introduces the 1st International Workshop on Digital Platforms and Resources for Access to Literary Heritage (DIPRAL 2022), a premier scientific forum aiming to disseminate the recent trends, innovative approaches and future challenges in ...
Berte M., Amelio A., Ursino D.
core  

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Reference Models for Digital Manufacturing Platforms

open access: yes, 2019
This paper presents an integrated reference model for digital manufacturing platforms, based on cutting edge reference models for the Industrial Internet of Things (IIoT) systems. Digital manufacturing platforms use IIoT systems in combination with other
Raul Poler   +3 more
core   +1 more source

Recent Advances in Superhydrophobic Materials Development for Maritime Applications

open access: yesAdvanced Science
Underwater superhydrophobic surfaces stand as a promising frontier in materials science, holding immense potential for applications in underwater infrastructure, vehicles, pipelines, robots, and sensors.
Zhao Qing Tang   +6 more
doaj   +1 more source

Digitalization and consumer protection enforcement

open access: yesInstitutiones Administrationis, 2022
The era of “new consumer protection” is marked by maximum harmonization rather minimum harmonization, (more) policy-based approach, legislation driven by the fast-emerging ecosystem of digital platforms, the strengthening of collective remedy and agency ...
Virág Balogh
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

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