Results 51 to 60 of about 925,427 (261)
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Recent Advances in Superhydrophobic Materials Development for Maritime Applications
Advanced ScienceUnderwater superhydrophobic surfaces stand as a promising frontier in materials science, holding immense potential for applications in underwater infrastructure, vehicles, pipelines, robots, and sensors.
Zhao Qing Tang +6 more
doaj +1 more source
Digital Manufacturing Platforms in the Industry 4.0 from Private and Public Perspectives
Applied Sciences, 2019 The fourth industrial revolution is characterized by the introduction of the Internet of things (IoT) and Internet of Services (IoS) concepts into manufacturing, which enables smart factories with vertically and horizontally integrated production systems.
Jon Kepa Gerrikagoitia +3 more
doaj +1 more source
The need for a new legal framework for VTC licenses to allow competition in the services of city transport -including taxis-. A matter of EC Competition Policy [PDF]
, 2017 In the recent years, the phenomenon of the sharing economy has played an important part in the market of the city transport of passengers. The performance of these digital platforms such as Uber, Blablacar or Cabify has been full of controversy.
Olmedo-Peralta, Eugenio
core
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
The Dynamics of Transformation in the Development of Digital Services [PDF]
, 2018 Service providers are increasingly depending and using digital infrastructure and tools provided by digital platforms to transform their services and develop digital ones that meet the needs of heterogeneous end users. However, while there is an emerging
Ghazawneh, Ahmad
core +1 more source
Management of Digital Video Broadcasting Services in Open Delivery Platforms [PDF]
, 2007 The future of Digital Video Broadcasting (DVB) is moving towards solutions offering an efficient way of carrying interactive IP multimedia services over digital terrestrial broadcasting networks to handheld terminals.
Casagranda, P +4 more
core +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Data Collection for Mental Health Studies Through Digital Platforms : Requirements and Design of a Prototype [PDF]
, 2017 Background: Mental and behavioral disorders are the main cause of disability worldwide. However, their diagnosis is challenging due to a lack of reliable biomarkers; current detection is based on structured clinical interviews which can be biased by the ...
Alakörkkö, Tuomas +6 more
core +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source