Results 41 to 50 of about 883,180 (266)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Developing auto-Didactic (Self-Learning) Skills by Using Social Networking [PDF]

open access: yesInternational Journal of Instructional Technology and Educational Studies, 2020
The recent research aims at checking the effectiveness of participating in the social networking sites on auto-didactic skills for university students.
Mohamed Turky, Nardeen Soliman
doaj   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

open access: yesFEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai   +4 more
wiley   +1 more source

A Multi-Dimensional Feature Analysis for Detecting and Mitigating AI-Generated Content in Academic Journal Articles

open access: yesZhishi guanli luntan
[Purpose/Significance] Investigating the characteristics of AI-generated academic journal content and establishing a multidimensional analytical framework are crucial for identifying improper use of AIGC in manuscripts, addressing challenges in peer ...
An Tong, Xue Dejun, Zhou Zhe, Kong Xiangyu, Geng Chong
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

open access: yesFEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas   +6 more
wiley   +1 more source

The Oligopoly of Academic Publishers in the Digital Era

open access: yesPLOS ONE, 2015
The consolidation of the scientific publishing industry has been the topic of much debate within and outside the scientific community, especially in relation to major publishers' high profit margins. However, the share of scientific output published in the journals of these major publishers, as well as its evolution over time and across various ...
Larivière, Vincent   +2 more
openaire   +4 more sources

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Semantic Publication of Agricultural Scientific Literature Using Property Graphs

open access: yesApplied Sciences, 2020
During the last decades, there have been significant changes in science that have provoked a big increase in the number of articles published every year. This increment implies a new difficulty for scientists, who have to do an extra effort for selecting
Francisco Abad-Navarro   +3 more
doaj   +1 more source

The Future of Digital Publishing

open access: yesRefract: An Open Access Visual Studies Journal, 2023
Peer review has long been held as the gold standard for article evaluation. At its simplest, the goal of peer review is to ensure that a published article in a journal has been appropriately vetted by qualified scholars. Traditional models require that this process is either single- or double-blind; the editor assigns reviewers based on subject ...
Gonder, Justin   +2 more
openaire   +3 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Home - About - Disclaimer - Privacy