Results 31 to 40 of about 38,197,336 (231)

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Institutional repositories in New Zealand: comparing institutional strategies for digital preservation and discovery [PDF]

, 2008
This paper outlines an ongoing project to create of a knowledge base to support the development of institutional repositories in New Zealand. The knowledge base wiki includes a summary of key literature to date, highlighting best practice, and standards ...
Chawner, Brenda, Cullen, Rowena
core   +1 more source

Towards a Holistic Approach to Policy Interoperabilityin Digital Libraries and Digital Repositories [PDF]

, 2011
Underpinning every digital library and digital repository there is a policy framework, which makes the digital library viable - without a policy framework a digital library is little more than a container for content. Policy governs how a digital library
Ashley, Kevin, De Robbio, Antonella, Pfeiffenberger, Hans, Faundeen, John, Innocenti, Perla, Ross, Seamus, Smith, MacKenzie   +6 more
core   +3 more sources

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Analysis of computational vulnerabilities in digital repositories

Biblios, 2015
Objective. Demonstrates the results of research that aimed to analyze the computational vulnerabilities of digital directories in public Universities. Argues the relevance of information in contemporary societies like an invaluable resource, emphasizing ...
Valdete Fernandes Belarmino, Wagner Junqueira Araújo   +1 more
doaj   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

Institutional Repositories in India [PDF]

, 2009
Institutional Repository (IR) disseminates rich source of digitized materials drafted and published by learned societies. In India major R& D institutes and few Academic Institutes provide an Institutional Repository (IR) service to its clientele.
Ashok Kumar, N.
core   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Privacy Impact Assessments for Digital Repositories

International Journal of Digital Curation, 2022
Trustworthy data repositories ensure the security of their collections. We argue they should also ensure the privacy of researcher and research subject data.
Abraham Mhaidli, Libby Hemphill, Florian Schaub, Jordan Cundiff, Andrea K. Thomer   +4 more
doaj   +1 more source