Results 51 to 60 of about 1,662,051 (304)

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

open access: yesMolecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy   +10 more
wiley   +1 more source

Protecting human rights in the digital age: Legal frameworks and media literacy as a complementary safeguard

open access: yesЦифровое право
The expansion of digital technologies has reshaped the exercise of fundamental rights, prompting growing scholarly and regulatory attention to the notion of digital human rights.
N. Nfissi
doaj   +1 more source

Digital libraries and information literacy issues within virtual learning environments : an e-learning impasse? [PDF]

open access: yes, 2005
The DIDET digital library and VLE approach places much of the responsibility for managing the digital library work flow into the hands of students, as well as academics and librarians. Student responsibilities include the application of metadata, as well
Macgregor, George, McGill, Lou
core  

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

open access: yesMolecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel   +12 more
wiley   +1 more source

Digital technologies in investment activities

open access: yesE-Management
The issues of development of digital financial technologies in the Russian Federation (hereinafter referred to as RF, Russia) are investigated. The article considers foreign and domestic experience of using digital technologies in financial and ...
V. V. Prokhorov, I. P. Rozhnov
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

The Implementation of European Union Digital Single Market Directive Article 17

open access: yesSakarya Üniversitesi Hukuk Fakültesi Dergisi/Sakarya Hukuk Dergisi
The article offers a comprehensive analysis of the Digital Single Market Directive of the European Union, with a specific emphasis on Article 17. The Directive aims to achieve the objectives of unifying copyright laws throughout the European Union while ...
Muhammed Furkan Akıncı
doaj   +1 more source

Digital technologies in the process of reforming the judiciary

open access: yesAspekti Publìčnogo Upravlìnnâ, 2020
The essence and content of digital technologies in the framework of judicial reform have been studied. The issue of information security security is considered. The peculiarities of digital services in the judicial system are studied.
Yulia Chornomorets
doaj   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

open access: yesFEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada   +5 more
wiley   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

open access: yesFEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida   +6 more
wiley   +1 more source

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