Results 31 to 40 of about 595,335 (304)

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

A Ring-LWE-based digital signature inspired by Lindner–Peikert scheme

Journal of Mathematical Cryptology, 2022
In this article, we give a digital signature by using Lindner–Peikert cryptosystem. The security of this digital signature is based on the assumptions about hardness of Ring-LWE and Ring-SIS problems, along with providing public key and signature of ...
Sharafi Javad, Daghigh Hassan
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

A Study on the Interoperability Technology of Digital Identification Based on WACI Protocol with Multiparty Distributed Signature

Sensors, 2023
In digital identity authentication, credentials are typically stored in a digital wallet and authenticated through a single key-based signature and public key verification.
Jihwan Kim, Pyung Kim, Daeseon Choi, Younho Lee   +3 more
doaj   +1 more source

Key Substitution in the Symbolic Analysis of Cryptographic Protocols (extended version) [PDF]

, 2007
Key substitution vulnerable signature schemes are signature schemes that permit an intruder, given a public verification key and a signed message, to compute a pair of signature and verification keys such that the message appears to be signed with the ...
Chevalier, Yannick, Kourjieh, Mounira
core   +2 more sources

Experimental measurement-device-independent quantum digital signatures over a metropolitan network [PDF]

, 2017
Quantum digital signatures (QDS) provide a means for signing electronic communications with informationtheoretic security. However, all previous demonstrations of quantum digital signatures assume trusted measurement devices. This renders them vulnerable
Andersson, Erika, Chen, Teng-Yun, Curty, Marcos, Jiang, Xiao, Li, Hao, Liu, Hui, Liu, Yang, Ma, Xiongfeng, Pan, Jian-Wei, Puthoor, Ittoop Vergheese, Sun, Xiang-Xiang, Tang, Yan-Lin, Wang, Wei-Long, Wang, Zhen, Yin, Hua-Lei, You, Li-Xing, Zhang, Qiang, Zhang, Wei-Jun, Zhao, Qi   +18 more
core   +2 more sources

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

ANALYSIS OF DIGITAL SIGNATURE RULE IN THE ELECTRONIC COMMERCE LAW OF INDONESIA

Mimbar Hukum, 2015
The Indonesian legislature has enacted the Information and Electronic Transaction Bill (the Bill) in 2003, in which digital signature as a technology specific electronic (e) commerce has been promoted.
Irna Nurhayati
doaj  

Digital signature [PDF]

, 2008
Digitálního podpisu, které je námětem této semestrální práce, je v současnosti velmi aktuální. Se stále vzrůstajícími možnostmi internetu a vidinou snižující se četnosti používání papírové dokumentace bylo nutné vyvinout metodu podepisování ...
Vaverka, Aleš
core