Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Advances in Digital Signature Algorithms: Performance, Security and Future Prospects [PDF]
ITM Web of ConferencesWith the rise of online transactions and digital communications, digital signatures have become essential for verifying document integrity and authenticity across fields like finance, government, and healthcare.
Lyu Shuhan
doaj +1 more source
International Journal of Electronics and Communications System, 2021 The digital signature generation process begins with the creation of a public key and a private key. A public key is generated and published to verify the signature and calculate the hash value of the received document.
Asep Saepulrohman, Agus Ismangil
doaj +1 more source
Deciphering the molecular signature of selective neuronal vulnerability in the wake‐promoting lateral hypothalamic area in Alzheimer’s disease: A digital multiplexed gene expression study across Braak stages [PDF]
, 2023 Abhijit Satpati +14 more
openalex +1 more source
Legal issues and technical aspects on mechanism of digital signature in Malaysia [PDF]
, 2006 The Digital Signature Act 1997 (Act 562 (hereinafter called “the Act”) came into force since 1 October 1998 to regulate the use of digital signature and to provide for matters connected therewith in Malaysia.
Goh, Choon Yih, Tay, Eng Siang
core
Automated Inference of Past Action Instances in Digital Investigations
, 2014 As the amount of digital devices suspected of containing digital evidence increases, case backlogs for digital investigations are also increasing in many organizations.
Gladyshev, Pavel, James, Joshua I.
core +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
A Forward-Secure Digital Signature Based on Elliptic Curve
Dianxin kexue, 2015 The forward-secure digital signature is an important digital signature scheme.It requires that even if the attackers have already been given a signature key by invading a system in t time，it still can’t forge signatures before time t.In other words，the ...
Huiyan Chen +4 more
doaj +2 more sources
FEBS Open Bio, EarlyView.Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava +3 more
wiley +1 more source
Beyond description: in search of disciplinary digital capabilities through signature pedagogies
Research in Learning Technology, 2020 The development of digital capabilities has received significant attention in higher education (HE) in recent years, with various attempts made to develop digital frameworks to support curriculum design.
Tünde Varga-Atkins
doaj +1 more source