Results 61 to 70 of about 609,879 (270)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
POSSIBILIDADE JURÍDICA DA CONTESTAÇÃO DA ASSINATURA DIGITAL – LEGAL CHALLENGE OF DIGITAL SIGNATURE
Revista da Seção Judiciária do Rio de Janeiro, 2013 This article studies the possibility of legal dispute of digital signature confirmation, as well the legal rules and the burden of proof related to repudiation of electronic document authorship.
Claudio Felipe Alexandre Magioli Núñez
doaj
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source
Digital Signature Schemes with Complementary Functionality and Applications
Безопасность информационных технологий, 2012 Digital signature schemes with additional functionality (an undeniable signature, a signature of the designated confirmee, a signature blind, a group signature, a signature of the additional protection) and examples of their application are considered ...
S. N. Kyazhin
doaj
FEBS Open Bio, EarlyView.Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava +3 more
wiley +1 more source
Cryptanalysis and improvement of several certificateless digital signature schemes
Tongxin xuebao, 2008 The security flaws of the certificateless digital signature schemes proposed by Liu-Au-Susilo （2007）,Goranlta-Saxena （2005）,Cao-Paterson-Kou（2006）,Yap-Heng-Goi（2006） and Je Hong Park（2006）were analyzed.
WANG Hua-qun1 +2 more
doaj +2 more sources
Data processing large quantities of multispectral information [PDF]
, 1975 Method is combination of digital and optical techniques. Multispectral data is coded into binary matrix format and then encoded onto photographic film. Film is holographically correlated with spectral signature to generate single-class classification map.
Haskell, R. E.
core +1 more source
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
On the Classification of Proxy Digital Signature Schemes
Безопасность информационных технологий, 2010 We provide a classification of proxy digital signature schemes based on common classification of digital signature schemes of Z. Cao, which is modified according to new functionality requirements of the schemes.
A. A. Varfolomeev
doaj