Results 41 to 50 of about 79,469 (260)
Early Impact of Childhood Opportunity on Neurocognitive Outcomes in Sickle Cell Disease
Pediatric Blood &Cancer, EarlyView.ABSTRACT Introduction Neurocognitive impairment is a well‐recognized complication of sickle cell disease (SCD) that begins early in childhood and persists across development. While cerebrovascular injury contributes substantially to risk, neurocognitive deficits are also observed in children without overt or silent cerebral infarctions, suggesting ...
Julia E. LaMotte +5 more
wiley +1 more source
Securing Additive Manufacturing with Blockchains and Distributed Physically Unclonable Functions
Cryptography, 2020 Blockchain technology is a game-changing, enhancing security for the supply chain of smart additive manufacturing. Blockchain enables the tracking and recording of the history of each transaction in a ledger stored in the cloud that cannot be altered ...
Bertrand Cambou +9 more
doaj +1 more source
IET Information Security, 2021 With the flourishing development of the Internet of Things (IoT), the electronic health system (EHS) as a leading technology has attracted widespread attention. However, the unsatisfactory network transmission throughput hinders practical applications of
Yumei Li, Futai Zhang, Yinxia Sun
doaj +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Software Update Methodologies for Feature-Based Product Lines: A Combined Design Approach
SoftwareThe automotive industry is experiencing a significant shift, transitioning from traditional hardware-centric systems to more advanced software-defined architectures. This change is enabling enhanced autonomy, connectivity, safety, and improved in-vehicle
Abir Bazzi, Adnan Shaout, Di Ma
doaj +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Blockchain: A Crypto-Intensive Technology—A Comprehensive Review
IEEE Access, 2023 Blockchain has shifted the paradigm of computer-based commercial applications during the last decade. Initially developed as a public ledger for Bitcoin transactions, it has already shown that it has the potential to revolutionize the world, where trust,
Muhammad Imran Sarwar +4 more
doaj +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Secure and Efficient Code-Based Cryptography for Multi-Party Computation and Digital Signatures
Computer Sciences & Mathematics Forum, 2023 Code-based cryptography is a promising candidate for post-quantum cryptography due to its strong security guarantees and efficient implementations. In this paper, we explore the use of code-based cryptography for multi-party computation and digital ...
Abdellatif Kichna, Abderrazak Farchane
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source