Results 61 to 70 of about 2,951,430 (303)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

TMC4 localizes to multiple taste cell types in the mouse taste papillae

FEBS Open Bio, EarlyView.
Transmembrane channel‐like 4 (TMC4), a voltage‐dependent chloride channel, plays a critical role in amiloride‐insensitive salty taste transduction. TMC4 is broadly expressed in all mature taste cell types, suggesting a possible involvement of multiple cell types in this pathway.
Momo Murata, Yoshikazu Saito, Yoichi Kasahara, Wataru Fujii, Takumi Misaka, Tomiko Asakura, Masataka Narukawa   +6 more
wiley   +1 more source

V3+ extends the V3 framework to ensure user-centricity and scalability of sensor-based digital health technologies

npj Digital Medicine
We propose the addition of usability validation to the extended V3 framework, now “V3+”, and describe a pragmatic approach to ensuring that sensor-based digital health technologies can be used optimally at scale by diverse users.
Jessie P. Bakker, Roland Barge, Jacob Centra, Bryan Cobb, Chas Cota, Christine C. Guo, Bert Hartog, Nathalie Horowicz-Mehler, Elena S. Izmailova, Nikolay V. Manyakov, Samantha McClenahan, Stéphane Motola, Smit Patel, Oana Paun, Marian Schoone, Emre Sezgin, Thomas Switzer, Animesh Tandon, Willem van den Brink, Srinivasan Vairavan, Benjamin Vandendriessche, Bernard Vrijens, Jennifer C. Goldsack   +22 more
doaj   +1 more source

A Dual-Branch Deep Learning Architecture for Multisensor and Multitemporal Remote Sensing Semantic Segmentation

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing, 2023
Multisensor data analysis allows exploiting heterogeneous data regularly acquired by the many available remote sensing (RS) systems. Machine- and deep-learning methods use the information of heterogeneous sources to improve the results obtained by using ...
Luca Bergamasco, Francesca Bovolo, Lorenzo Bruzzone   +2 more
doaj   +1 more source

Responsible research and innovation in science education: insights from evaluating the impact of using digital media and arts-based methods on RRI values [PDF]

, 2020
The European Commission policy approach of Responsible Research and Innovation (RRI) is gaining momentum in European research planning and development as a strategy to align scientific and technological progress with socially desirable and acceptable ...
Berrens Torruella, Karla, Heras López, Maria, Ruiz Mallen, Isabel   +2 more
core   +1 more source

Understanding bio‐based polymers: A study of origins, properties, biodegradation and their impact on health and the environment

FEBS Open Bio, EarlyView.
This review provides an overview of bio‐based polymer sources, their unique functional properties and their environmental impact, and addresses their role as sustainable alternatives. It discusses end‐of‐life options, including composting and anaerobic digestion for renewable energy.
Sabina Kolbl Repinc, Blaž Stres, Mirica Karlovits, Igor Karlovits, Petra Jerič, Ondrej Panák, Anja Verbič, Blaž Likozar, Uroš Novak   +8 more
wiley   +1 more source

When Science Communication Becomes Parascience: Blurred Boundaries, Diffuse Roles

Publications, 2022
The communication of science goes hand in hand with technological development and, in general, with the need to apply scientific advancements to the improvement of human wellbeing [...]
Pilar Mur-Dueñas, Rosa Lorés
doaj   +1 more source

Evolution of the digital society reveals balance between viral and mass media influence

, 2014
Online social networks (OSNs) enable researchers to study the social universe at a previously unattainable scale. The worldwide impact and the necessity to sustain their rapid growth emphasize the importance to unravel the laws governing their evolution.
Boguna, Marian, Kleineberg, Kaj-Kolja
core   +2 more sources

Digital information and the 'privatisation of knowledge' [PDF]

, 2007
Purpose of this paper: To point out that past models of information ownership may not carry over to the age of digital information. The fact that public ownership of information (for example, by means of national and public library collections) created ...
Adobe, Australian Library Collections Task Force, Legal Deposit Libraries Act, Mills E., Muddiman D., Nicholas Joint, ScienceDirect, The, UKWAC   +8 more
core   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source