Results 41 to 50 of about 32,563 (195)
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Digital systems in pharmacovigilance: Enhancing adverse drug reaction detection in endocrine disorders [PDF]
Medicinski Glasnik Specijalne Bolnice za Bolesti Štitaste Žlezde i Bolesti Metabolizma "Zlatibor"Objective: To examine the efficacy of digital systems in improving the detection and management of adverse drug reactions (ADRs) in patients with endocrine disorders, focusing on diabetes, hypothyroidism, and hyperprolactinemia.
Kimi Milić Marko +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
Journal of Applied Informatics and ComputingThe adoption of digital systems for social assistance distribution has become increasingly vital in enhancing efficiency and accessibility. This study examines the acceptance of such a system using the Unified Theory of Acceptance and Use of Technology ...
Soni Adiyono +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Diacronie. Studi di Storia Contemporanea, 2011 This article analyzes and typifies all production referring to the International Brigades and “Brigadistas” in the current context of recuperating the historical memory of the Spanish Civil War. This includes historical, literary, political, sociological,
Lourdes Prades-Artigas es Doctora en Historia Contemporánea y Directora de la Biblioteca del Pavelló de la República (Universitat de Barcelona). Actualmente participa en la investigación en el Proyecto: “La memoria histórica y las Brigadas Internacionales: diseño de un sistema digital para la transferencia del conocimiento sobre el patrimonio histórico español” (Reconocido como Proyecto I+D+I del Ministerio de Ciencia y Tecnología, (HAR2010-20983-subprograma HIST). Entre sus principales publicaciones recordamos: «I Miliziani delle Brigate Internazionali della Guerra civile spagnola e la memoria storica: SIDBRI, un sistema di informazione digitale», Spagna Contemporanea, núm. 36, 2009, pp. 193-216 (con Montserrat Sebastiá); «El fons documental de l’arxiu-biblioteca del Pavelló de la República de la Universitat de Barcelona», en Espai, art i memòria: el Pavelló de la República (París 1937-Barcelona 2007), Barcelona, Publicacions i Edicions de la Universitat de Barcelona, 2008, pp. 103-115 (con Olga Giralt); Els Brigadistes de la Guerra Civil espanyola en les fonts documentals: un prototipus de sistema d’informació digital, Tesi doctoral. Barcelona, Universitat de Barcelona, 2008; «Fons hemerogràfic de la Biblioteca del Pavelló de la República (Universitat de Barcelona): VI Colloqui Aula d’Història del Periodisme Diari de Barcelona», Treballs de comunicació: Societat Catalana de Comunicació (Barcelona), núm, 18, (desembre) 2003, pp. 193-196. En publicación: «‘Forjant’ El imperio del libro católico y españolísimo” l’edició a Catalunya durant els primers anys del Franquisme» dins Congrés Internacional La dictadura franquista: la institucionalització d’un règim, Barcelona, Universitat de Barcelona, Facultat de Geografia i Història, 2011.
doaj
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source