Results 71 to 80 of about 2,184,166 (294)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

A Program Logic for Reasoning About C11 Programs With Release-Sequences

IEEE Access, 2020
With the popularity of weak/relaxed memory models widely used in modern hardware architectures, the C11 standard introduced a language level weak memory model, A.K.A the C11 memory model, that allows C/C++ programs to exploit the optimisation provided by
Mengda He, Shengchao Qin, Zhiwu Xu
doaj   +1 more source

GeoCoin:supporting ideation and collaborative design with location-based smart contracts [PDF]

, 2018
Design and HCI researchers are increasingly working with complex digital infrastructures, such as cryptocurrencies, distributed ledgers and smart contracts. These technologies will have a profound impact on digital systems and their audiences.
Mehrpouya, Hadi, Murray-Rust, Dave, Nissen, Bettina, Oosthuizen, Shaune, Pschetz, Larissa, Speed, Chris   +5 more
core   +2 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Reflecting on Digital Art Value: NFTs’ Potential for the Art-Market Parity

Digital Humanities in the Nordic and Baltic Countries Publications
Until recently, digital art was perceived as something of secondary value compared to the physical artistic artifacts. One of the reasons for that being its predisposition for duplication and hence the inability to assign “original artwork” label to the
Darja Tokranova, Merja Lina Bauters
doaj   +1 more source

Post-digital humanities: computation and cultural critique in the arts and humanities [PDF]

, 2014
Today we live in computational abundance whereby our everyday lives and the environment that surrounds us are suffused with digital technologies. This is a world of anticipatory technology and contextual computing that uses smart diffused computational ...
Berry, David M
core   +1 more source

TMC4 localizes to multiple taste cell types in the mouse taste papillae

FEBS Open Bio, EarlyView.
Transmembrane channel‐like 4 (TMC4), a voltage‐dependent chloride channel, plays a critical role in amiloride‐insensitive salty taste transduction. TMC4 is broadly expressed in all mature taste cell types, suggesting a possible involvement of multiple cell types in this pathway.
Momo Murata, Yoshikazu Saito, Yoichi Kasahara, Wataru Fujii, Takumi Misaka, Tomiko Asakura, Masataka Narukawa   +6 more
wiley   +1 more source

Automated Real-Time Localized Sea State Estimation During Navigation Based on the Beaufort Scale

IEEE Open Journal of Intelligent Transportation Systems
This work presents an automated, real-time approach for localized sea state estimation using a single camera mounted on a ship’s bridge. A labeled dataset of sea surface images, collected during regular operation of an overseas liner, is built and
M. Pobar, G. Paulin, M. Ivasic-Kos, A. Vorkapic   +3 more
doaj   +1 more source

Robust Fusion of LiDAR and Wide-Angle Camera Data for Autonomous Mobile Robots

Sensors, 2018
Autonomous robots that assist humans in day to day living tasks are becoming increasingly popular. Autonomous mobile robots operate by sensing and perceiving their surrounding environment to make accurate driving decisions.
Varuna De Silva, Jamie Roche, Ahmet Kondoz   +2 more
doaj   +1 more source