Molecular Oncology, EarlyView.This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad +17 more
wiley +1 more source
Bidirectional reinforcement learning neural network for constrained molecular design
Scientific ReportsWe present BiRLNN, a bidirectional molecular design framework that combines recurrent neural networks with reinforcement learning to optimize drug-like properties of generated compounds.
Junan Lin +5 more
doaj +1 more source
Systematic literature review of digital and green transformation of manufacturing SMEs in Europe
Production and Manufacturing Research: An Open Access JournalThe digital and green transformation of the manufacturing industry is gaining attention in research and practice, often referred to as twin transition. However, understanding twin transitions in SMEs is limited.
Anar Abilakimova +2 more
doaj +1 more source
Test Technology of Digital Prototype for Electric Resistance Equipment and Its Application in Simulation Platform [PDF]
, 2022 Zhijun Zhu +4 more
openalex +1 more source
Teaching and Learning in Times of COVID-19: Uses of Digital Technologies During School Lockdowns
Frontiers in Psychology, 2021 The closure of schools as a result of COVID-19 has been a critical global incident from which to rethink how education works in all our countries. Among the many changes generated by this crisis, all teaching became mediated by digital technologies. This
J. Pozo +3 more
semanticscholar +1 more source
Screening for lung cancer: A systematic review of overdiagnosis and its implications
Molecular Oncology, EarlyView.Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz +12 more
wiley +1 more source
VNFlow: integration of variational autoencoders and normalizing flows for novel molecular design
Journal of CheminformaticsGenerative Artificial Intelligence is transforming the molecular discovery by enabling exploration of the vast, largely unexplored chemical space. However, current methods, including normalizing flows, struggle to balance the optimization of complex ...
Jiří Hostaš +5 more
doaj +1 more source
wav2vec and its current potential to Automatic Speech Recognition in German for the usage in Digital History: A comparative assessment of available ASR-technologies for the use in cultural heritage contexts [PDF]
, 2023 Michael Fleck, Wolfgang Göderle
openalex +1 more source
Metacognition in Autism Spectrum Disorder: Digital Technologies in Metacognitive Skills Training
Technium Social Sciences Journal, 2022 Extensive research has been conducted regarding socio-emotional skills training in autism spectrum disorder (ASD). The latest autism research is now beginning to recognize the role of metacognitive deficits in ASD as well as the importance of ...
Eleni Mitsea, A. Drigas, C. Skianis
semanticscholar +1 more source
Molecular Oncology, EarlyView.Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece +18 more
wiley +1 more source