Results 51 to 60 of about 40,734,559 (293)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Digital libraries for creative communities [PDF]

, 2004
Digital library technologies have a great deal to offer to creative, design communities. They can enable large collections of text, images, music, video and other information objects to be organised and accessed in interesting and diverse ways.
Jones, Matt, Bainbridge, David, Cantlon, Polly, Cunningham, Sally Jo, Witten, Ian H.   +4 more
core   +1 more source

Digital Innovation and Interactive Technologies : Educating the Society 5.0

, 2022
Is digital innovation helping towards achieving a higher level of education or not? Since the impact of technologies is affecting more of our society, it is also true that its use in education is still limited, even in university education, where it ...
Osello, Anna, Fonsati, Arianna
core   +1 more source

Primary Teachers' Perceptions of Their Students' Digital Technologies Competencies

, 2022
Digital technology has been firmly engrained within the Australian Curriculum for some years now. The recent review of the curriculum has given even greater emphasis to digital technologies as an integral component for teaching content, developing 21st ...
Cantle, Cantle, Albion, Peter, Martin, David, Smart, Vicky, Redmond, Petrea   +4 more
core   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Constructing digital library interfaces [PDF]

, 2007
The software technologies used to create web interfaces for digital libraries are discussed using examples from Greenstone ...
Nichols, David M., Bainbridge, David, David M. Nichols, David Bainbridge, Twidale, Michael B., Michael B. Twidale   +5 more
core   +1 more source

Digital technologies in agriculture

, 2022
Symposium Objectives The 1st International Symposium on Digital Technologies in Agriculture will enhance the exchange and dissemination of knowledge, experience, ideas and results.
Wilczewski, E., Kościński, M., Prakatur, Ivana, Šumanovac, Luka, Fruk, G., Pejić, P., Kovačić, Marin, Domazetović, D., Tolić, Snježana, Šimić, D., Iljkić, Dario, Lauc, I., Lončarić, Ružica, Rapčan, Irena, Bilić, D., Gałęzewski, L., Solić, D., Karnaš, Maja, Šperanda, Marcela, Gantner, Ranko, Užar, D., Rastija, Vesna, Jaman, F. Puškadija, Bobić, Tina, Magdić, L., Jaskulska, I., Garré, A., Đidara, Mislav, Kajasn, K., Hefer, H., Antolović, A. M...., Kušec, Goran, Jurišić, Mladen, Tačković, D., Lončarić, Zdenko, Rajičević D.,, Katarina Miljak, Mirjana Baban, Ivkić, Z., K,, ...Gantner, Vesna, Skendžić, S...., Baban, Mirjana, Grgić, D., Klir Šalavardić, Željka, Sudarić, Tihana, Wilczek, A., Andrišic, M., Šunić, A., Galić, V., Markovanović, G., Miljak,, Radočaj, Dorijan, Živić, Tihomir, Neubauer, A., Antunović, Zvonko, Schmit, P., Bestvina, N., Galić Subašić, Daria, Hasija, M., Majcher, J., Čirjak, D...., Plaščak, Ivan, Jelić Milković, Sanja, Novoselec, Josip, Brlić, M., ...,, Mijić, Pero, Kožul, M., Aleksi, I., Pavlić, M., Hederić, Ž., Dunđerski, D., Gregić, Maja, Madaras, Z, Šubarić, Domagoj, Ravlić, Marija, Varga, Ivana   +76 more
core   +1 more source

Bidirectional reinforcement learning neural network for constrained molecular design

Scientific Reports
We present BiRLNN, a bidirectional molecular design framework that combines recurrent neural networks with reinforcement learning to optimize drug-like properties of generated compounds.
Junan Lin, Jiří Hostaš, Anguang Hu, Hang Hu, Hsu Kiang Ooi, Mohammad Sajjad Ghaemi   +5 more
doaj   +1 more source

Machine Learning in Forecasting Labor Market: A Systematic Literature Review

IEEE Access
Rapid changes and advancements in science and technology continuously reshape the labor market. With the emergence of new intelligent systems, traditional work practices become obsolete, new occupations arise, while some existing roles decline.
Aladdin Shikhizada, Danial Hooshyar, David Jose Ribeiro Lamas   +2 more
doaj   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source