Results 51 to 60 of about 548,033 (257)

An updated Gappy-POD to capture non-parameterized geometrical variation in fluid dynamics problems

Advanced Modeling and Simulation in Engineering Sciences, 2022
In this work, we propose a new method to fill the gap within an incomplete turbulent and incompressible data field in such a way to satisfy the topological and intensity changes of the fluid flow after a non-parameterized geometrical variation in the ...
Nissrine Akkari, Fabien Casenave, David Ryckelynck, Christian Rey   +3 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

A Physics-Guided Machine Learning Algorithm for Non-Ionizing Femur Fracture Classification from RF Spectral Data

Algorithms
This paper presents a physics-guided machine learning algorithm for classifying femur fracture presence and subtype using non-ionising radiofrequency (RF) spectral data.
Prince O. Siaw, Yacine Chahba, Ebenezer Adjei, Ahmad Aldelemy, Salamatu Ibrahim, Raed Abd-Alhameed   +5 more
doaj   +1 more source

Technology Management in the Age of Digital Technologies [PDF]

IEEE Transactions on Engineering Management, 2023
Dilek Cetindamar Kozanoglu, Robert Phaal
openaire   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Development of an Early Lung Cancer Diagnosis Method Based on a Neural Network

Computers
Cancer is one of the most lethal diseases in the modern world. Early diagnosis significantly contributes to prolonging the life expectancy of patients. The application of intelligent systems and AI methods is crucial for diagnosing oncological diseases ...
Indira Karymsakova, Dinara Kozhakhmetova, Dariga Bekenova, Danila Ostroukh, Roza Bekbayeva, Lazat Kydyralina, Alina Bugubayeva, Dinara Kurushbayeva   +7 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

On the state feedback control of inverted pendulum with hysteretic nonlinearity

MATEC Web of Conferences, 2014
In this paper we consider the mathematical model of the inverted pendulum with the hysteretic nonlinearity (in the form of backlash) under state feedback control.
Semenov Mikhail E., Grachikov Dmitry V., Rukavitsyn Anton G., Meleshenko Peter A.   +3 more
doaj   +1 more source