Results 51 to 60 of about 478,855 (256)

Development of an Early Lung Cancer Diagnosis Method Based on a Neural Network

Computers
Cancer is one of the most lethal diseases in the modern world. Early diagnosis significantly contributes to prolonging the life expectancy of patients. The application of intelligent systems and AI methods is crucial for diagnosing oncological diseases ...
Indira Karymsakova, Dinara Kozhakhmetova, Dariga Bekenova, Danila Ostroukh, Roza Bekbayeva, Lazat Kydyralina, Alina Bugubayeva, Dinara Kurushbayeva   +7 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

A Physics-Guided Machine Learning Algorithm for Non-Ionizing Femur Fracture Classification from RF Spectral Data

Algorithms
This paper presents a physics-guided machine learning algorithm for classifying femur fracture presence and subtype using non-ionising radiofrequency (RF) spectral data.
Prince O. Siaw, Yacine Chahba, Ebenezer Adjei, Ahmad Aldelemy, Salamatu Ibrahim, Raed Abd-Alhameed   +5 more
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

On the state feedback control of inverted pendulum with hysteretic nonlinearity

MATEC Web of Conferences, 2014
In this paper we consider the mathematical model of the inverted pendulum with the hysteretic nonlinearity (in the form of backlash) under state feedback control.
Semenov Mikhail E., Grachikov Dmitry V., Rukavitsyn Anton G., Meleshenko Peter A.   +3 more
doaj   +1 more source

Two-dimensional mathematical model of heat and moisture transfer processes during the natural storage and drying of heterogeneous agricultural products [PDF]

BIO Web of Conferences
Developed a two-dimensional mathematical model of simultaneous heat and moisture transfer processes during the natural storage and drying of heterogeneous agricultural products in open areas.
Shadmanov Istam, Nosirova Zarnigor, Kamolova Umida   +2 more
doaj   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

Technology Management in the Age of Digital Technologies [PDF]

IEEE Transactions on Engineering Management, 2023
Dilek Cetindamar Kozanoglu, Robert Phaal
openaire   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source