Results 31 to 40 of about 548,033 (257)

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

A Conversation between Learning Design and Classroom Observations: A Systematic Literature Review

Education Sciences, 2019
Learning Design, as a field of research, provides practitioners with guidelines towards more effective teaching and learning. In parallel, observational methods (manual or automated) have been used in the classroom to reflect on and refine teaching and ...
Maka Eradze, María Jesús Rodríguez-Triana, Mart Laanpere   +2 more
doaj   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

A Wilson–Cowan reservoir computer for interpretable spatiotemporal vision

Scientific Reports
We present a Wilson–Cowan reservoir computer (WC–RC) that treats a retinotopic excitatory–inhibitory neural field as a structured reservoir. Travelling waves and bounded oscillations provide an interpretable spatiotemporal basis, while a two-stage ...
Sharmarke A. Gabayre, Sergey Savel’ev, Varuna De Silva, Mindula Illeperuma, Xiyu Shi   +4 more
doaj   +1 more source

Humanization of digital technologies

Human Technology
This editorial introduces the special issue arising from the "11th International Conference on Communities and Technologies - Humanisation of Digital Technologies". It sets the stage for a series of papers that illustrate a shift from technology-centred to human-centred approaches in the development of digital technologies. The editorial highlights the
Siemon Dominik, Wolff Annika
openaire   +2 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Bidirectional reinforcement learning neural network for constrained molecular design

Scientific Reports
We present BiRLNN, a bidirectional molecular design framework that combines recurrent neural networks with reinforcement learning to optimize drug-like properties of generated compounds.
Junan Lin, Jiří Hostaš, Anguang Hu, Hang Hu, Hsu Kiang Ooi, Mohammad Sajjad Ghaemi   +5 more
doaj   +1 more source

Systematic literature review of digital and green transformation of manufacturing SMEs in Europe

Production and Manufacturing Research: An Open Access Journal
The digital and green transformation of the manufacturing industry is gaining attention in research and practice, often referred to as twin transition. However, understanding twin transitions in SMEs is limited.
Anar Abilakimova, Merja Bauters, Abiodun Afolayan Ogunyemi   +2 more
doaj   +1 more source