Results 31 to 40 of about 478,855 (256)
A Conversation between Learning Design and Classroom Observations: A Systematic Literature Review
Education Sciences, 2019 Learning Design, as a field of research, provides practitioners with guidelines towards more effective teaching and learning. In parallel, observational methods (manual or automated) have been used in the classroom to reflect on and refine teaching and ...
Maka Eradze +2 more
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Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
A Systematic Review and Empirical Analysis of Blockchain Simulators
IEEE Access, 2021 In recent years, distributed ledger technologies, and especially blockchain, have gained tremendous interest from academia, government, and industry. Although various blockchain-based solutions were created, the lack of tools to evaluate these complex ...
Remigijus Paulavicius +2 more
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Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Overcoming Challenges of Applying Reinforcement Learning for Intelligent Vehicle Control
Sensors, 2021 Reinforcement learning (RL) is a booming area in artificial intelligence. The applications of RL are endless nowadays, ranging from fields such as medicine or finance to manufacturing or the gaming industry.
Rafael Pina +4 more
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Bidirectional reinforcement learning neural network for constrained molecular design
Scientific ReportsWe present BiRLNN, a bidirectional molecular design framework that combines recurrent neural networks with reinforcement learning to optimize drug-like properties of generated compounds.
Junan Lin +5 more
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Systematic literature review of digital and green transformation of manufacturing SMEs in Europe
Production and Manufacturing Research: An Open Access JournalThe digital and green transformation of the manufacturing industry is gaining attention in research and practice, often referred to as twin transition. However, understanding twin transitions in SMEs is limited.
Anar Abilakimova +2 more
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Towards Interpretable Camera and LiDAR Data Fusion for Autonomous Ground Vehicles Localisation
Sensors, 2022 Recent deep learning frameworks draw strong research interest in application of ego-motion estimation as they demonstrate a superior result compared to geometric approaches. However, due to the lack of multimodal datasets, most of these studies primarily
Haileleol Tibebu +4 more
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