Results 41 to 50 of about 478,855 (256)

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Humanization of digital technologies

Human Technology
This editorial introduces the special issue arising from the "11th International Conference on Communities and Technologies - Humanisation of Digital Technologies". It sets the stage for a series of papers that illustrate a shift from technology-centred to human-centred approaches in the development of digital technologies. The editorial highlights the
Siemon Dominik, Wolff Annika
openaire   +2 more sources

VNFlow: integration of variational autoencoders and normalizing flows for novel molecular design

Journal of Cheminformatics
Generative Artificial Intelligence is transforming the molecular discovery by enabling exploration of the vast, largely unexplored chemical space. However, current methods, including normalizing flows, struggle to balance the optimization of complex ...
Jiří Hostaš, Mohammad S. Ghaemi, Hang Hu, Junan Lin, Anguang Hu, Hsu K. Ooi   +5 more
doaj   +1 more source

On the Role of Regulatory Policy on the Business Case for Energy Storage in Both EU and UK Energy Systems: Barriers and Enablers

Energies, 2020
This paper presents a SWOT analysis of the impact of recent EU regulatory changes on the business case for energy storage (ES) using the UK as a case study. ES technologies (such as batteries) are key enablers for increasing the share of renewable energy
Ahmed Gailani, Tracey Crosbie, Maher Al-Greer, Michael Short, Nashwan Dawood   +4 more
doaj   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Lifetime Degradation Cost Analysis for Li-Ion Batteries in Capacity Markets using Accurate Physics-Based Models

Energies, 2020
Capacity markets (CM) are energy markets created to ensure energy supply security. Energy storage devices provide services in the CMs. Li-ion batteries are a popular type of energy storage device used in CMs.
Ahmed Gailani, Maher Al-Greer, Michael Short, Tracey Crosbie, Nashwan Dawood   +4 more
doaj   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

An updated Gappy-POD to capture non-parameterized geometrical variation in fluid dynamics problems

Advanced Modeling and Simulation in Engineering Sciences, 2022
In this work, we propose a new method to fill the gap within an incomplete turbulent and incompressible data field in such a way to satisfy the topological and intensity changes of the fluid flow after a non-parameterized geometrical variation in the ...
Nissrine Akkari, Fabien Casenave, David Ryckelynck, Christian Rey   +3 more
doaj   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source