Results 41 to 50 of about 2,232,966 (294)
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
IET Smart CitiesNatural disaster management approach establishes stages of prevention, preparation, response, and recovery. With the Internet of Things (IoT), Bigdata, Business Intelligence, and other Information Communication Technologies, data can be gathered to ...
Alessandro S. Santos +7 more
doaj +1 more source
Digital impact, crossover technologies and gambling practices [PDF]
, 2008 At this juncture it is instructive to review the convergent media forms as a starting point for a wider debate about the pervasiveness of games technologies and gambling practices. In particular, to focus upon convergences between gambling and gaming and
Griffiths, MD
core
Seven Dimensions of Portability for Language Documentation and Description
, 2002 The process of documenting and describing the world's languages is undergoing radical transformation with the rapid uptake of new digital technologies for capture, storage, annotation and dissemination.
Bird, Steven, Simons, Gary
core +6 more sources
Uncertain impacts of new technologies: the case of digital agriculture and blockchains [PDF]
, 2019 Digital innovations are central to the transformation of food systems, from production and processing through to distribution. While they have the potential to enhance environmental and social sustainability across the value chain, they could also have ...
Hobeika, Alexandre +3 more
core +1 more source
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Overcoming Challenges of Applying Reinforcement Learning for Intelligent Vehicle Control
Sensors, 2021 Reinforcement learning (RL) is a booming area in artificial intelligence. The applications of RL are endless nowadays, ranging from fields such as medicine or finance to manufacturing or the gaming industry.
Rafael Pina +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Bidirectional reinforcement learning neural network for constrained molecular design
Scientific ReportsWe present BiRLNN, a bidirectional molecular design framework that combines recurrent neural networks with reinforcement learning to optimize drug-like properties of generated compounds.
Junan Lin +5 more
doaj +1 more source