Results 101 to 110 of about 5,201,214 (300)

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Digital Work: A Research Agenda [PDF]

, 2016
We have been invited to discuss “digital work” and to propose a research agenda for the next decade or so. We value the opportunity to share some thoughts on this important area.
Orlikowski, Wanda J
core  

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Vulnerabilities in digital platform-based work in the field of online transportation

Jurnal Inovasi Ilmu Sosial dan Politik
This study investigates the vulnerabilities and the illusion of well-being in platform-based digital work, focusing on drivers from Grab, Maxim, and Gojek in Tasikmalaya City.
Faisal Fadilla Noorikhsan, Nisa Khoerunisa, Taufik Nurohman, Randi Muchariman, Risna Amalia Hamzah   +4 more
doaj   +1 more source

Integrating digital document acquisition into a university library : A case study of social and organizational challenges [PDF]

, 2003
In this article we report on the effort of the university library of the Vienna University of Economics and Business Administration to integrate a digital library component for research documents authored at the university into the existing library ...
Hahsler, Michael
core  

Anchorage‐independent and faster growth in clonal population from UV‐irradiated NER‐deficient cells

FEBS Open Bio, EarlyView.
UV‐irradiated cells expressing a DDB2 mutant protein unable to interact with PCNA (DDB2PCNA‐) form clones able to grow without anchorage. Different experimental approaches reveal heterogeneity in cell cycle regulation and drug response within these clones, emphasizing the crucial role of the DDB2‐PCNA interaction in preventing cellular transformation ...
Paola Perucca, Anna Tricarico, Martina Furfaro, Priyam Ghosh, Ennio Prosperi, Lucia Anna Stivala, Ornella Cazzalini   +6 more
wiley   +1 more source

Digitalization of administrative work at home

i-com
Abstract People must perform bureaucratic, administrative work in daily life, such as applying for official documents, concluding contracts, organizing purchases, managing pension plans, etc. This work is time-consuming and unequally distributed in the household.
Erik Dethier, Gunnar Stevens, Alexander Boden   +2 more
openaire   +2 more sources

A Study of Legal Information Seeking Behaviour to Inform the Design of Electronic Legal Research Tools [PDF]

, 2006
Our work is motivated by the desire to support digital library users in ?getting to grips? with electronic resources. More specifically we are motivated by the desire to support users in understanding how to use, and in which situations it is appropriate
Blandford, A, Cox, AL, Makri, S
core  

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

York Digital Library : an ecological view of interactions and systems [PDF]

, 2009
This case study of York Digital Library examines the development of a digital library of images at the University of York. In particular, it examines the project phase of the Fedora-based digital library and its provision of service to the History of Art
Allinson, J., Robertson, R.J.
core