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[DIGITALIS TREATMENT AND DIGITALIS PREPARATIONS].
Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1996 openaire +1 more source
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The Journal of Clinical Pharmacology, 1985
The principal causes of digitalis toxicity are overdose, reduced volume of distribution, reduced renal elimination, and increased myocardial sensitivity. The metabolic mechanism of digitalis toxicity is intense inhibition of sarcolemma Na‐K ATPase, which leads to increases of intracellular Na+ and Ca2+ and arrhythmogenic membrane ionic currents.
E M, Antman, T W, Smith
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The principal causes of digitalis toxicity are overdose, reduced volume of distribution, reduced renal elimination, and increased myocardial sensitivity. The metabolic mechanism of digitalis toxicity is intense inhibition of sarcolemma Na‐K ATPase, which leads to increases of intracellular Na+ and Ca2+ and arrhythmogenic membrane ionic currents.
E M, Antman, T W, Smith
openaire +4 more sources
1986
The principal effect of cardioactive glycosides (CG) is the inhibition of the (Na+ + K+)-ATPase system with subsequent increase in contractility of the myocardium. In subtoxic and toxic concentrations, CG increase O2 consumption due to a transient Ca2+ overload.
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The principal effect of cardioactive glycosides (CG) is the inhibition of the (Na+ + K+)-ATPase system with subsequent increase in contractility of the myocardium. In subtoxic and toxic concentrations, CG increase O2 consumption due to a transient Ca2+ overload.
openaire +2 more sources