Results 121 to 130 of about 3,700,434 (389)

Contextual impacts on industrial processes brought by the digital transformation of manufacturing: a systematic review [PDF]

, 2019
The digital transformation of manufacturing (a phenomenon also known as "Industry 4.0" or "Smart Manufacturing") is finding a growing interest both at practitioner and academic levels, but is still in its infancy and needs deeper investigation.
Amendola, Carlo, Bellini, Francesco, D'Ascenzo, Fabrizio, Savastano, Marco   +3 more
core   +1 more source

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Aberrant expression of nuclear prothymosin α contributes to epithelial‐mesenchymal transition in lung cancer

Molecular Oncology, EarlyView.
Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen, Chung‐Teng Wang, Jia‐Ming Chang, Ai‐Li Shiau, Gia‐Shing Shieh, Yau‐Lin Tseng, Yi‐Ting Yen, Tang‐Hsiu Huang, Li‐Hsin Cheng, Yu‐Chih Wu, Chao‐Liang Wu, Bing‐Hua Su, Pensee Wu   +12 more
wiley   +1 more source

Internet of Things and Their Coming Perspectives: A Real Options Approach [PDF]

, 2019
Internet of things is developing at a dizzying rate, and companies are forced to implement it in order to maintain their operational efficiency. The high flexibility inherent to these technologies makes it necessary to apply an appropriate measure, which
Cruz Rambaud, Salvador, Sánchez Pérez, Ana María, Tarifa Fernández, Jorge   +2 more
core   +1 more source

Loss of proton‐sensing GPR4 reduces tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
G protein‐coupled receptor 4 (GPR4) is a pH‐sensing receptor activated by acidic pH. GPR4 expression is increased in patients with inflammatory bowel disease who are at high risk of developing colorectal cancer. In mouse models, loss of GPR4 attenuated tumor progression. This correlated with increased IL2 and natural killer cell activity.
Leonie Perren, Moana Busch, Pedro A. Ruiz, Ermanno Malagola, Valeria Baumeler, Federica Foti, Adelina Gross, Tobias Grütter, Hendrik Edel, Cordelia Schuler, Kristina Handler, Glenn De Lange, Isabelle C. Arnold, Cheryl de Vallière, Klaus Seuwen, Martin Hausmann, Gerhard Rogler   +16 more
wiley   +1 more source

Hydrostatic piezoelectric properties of 1-3 type piezo-composite with a porous polymer matrix

Journal of Asian Ceramic Societies
Piezoelectric sensors for underwater sonar require high hydrostatic piezoelectric properties (dh, gh and HFOM), and research is being conducted on various types of piezoelectric composites to improve them. In this study, research was conducted to improve
Jong-Ho Kim, Il-Gok Hong, Ho-Yong Shin, Hyo-Jun Ahn, Jong-In Im   +4 more
doaj   +1 more source

Digitalization and the American Workforce

, 2019
This Fact Sheet examines the rate of digitalization within the Metropolitan Statistical Areas (MSAs) of the Mountain West division using the findings and data from Digitalization and the American Workforce, a report from the Brookings ...
Blankenship, Mary, Brown, William E., Saladino, Caitlin   +2 more
core  

A framework for food supply chain digitalization: lessons from Thailand

, 2020
The promise of digitalization is enormous and nowhere is it more critical than in its potential to transform food supply chain. Consumers have become more educated and are demanding real-time updated information on foods they consumed through digital ...
Pichawadee Kittipanya-Ngam, K. Tan
semanticscholar   +1 more source

TRPM8 levels determine tumor vulnerability to channel agonists

Molecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo, Francesco Giuseppe Carbone, Kristi Buzo, Nicole Annesi, Sacha Genovesi, Annalisa Lorenzato, Karen Widmann, Michela Libergoli, Elisa Marmocchi, Giovanni Bertalot, Alberto Brolese, Mauro Giulio Papotti, Luca Molinaro, Orazio Caffo, Mattia Barbareschi, Alberto Bardelli, Alessandro Romanel, Sabrina Arena, Andrea Lunardi   +18 more
wiley   +1 more source

Route Optimization for UVC Disinfection Robot Using Bio-Inspired Metaheuristic Techniques

Biomimetics
The COVID-19 pandemic highlighted the urgent need for effective surface disinfection solutions, which has led to the use of mobile robots equipped with ultraviolet (UVC) lamps as a promising technology.
Mario Peñacoba, Eduardo Bayona, Jesús Enrique Sierra-García, Matilde Santos   +3 more
doaj   +1 more source