Results 11 to 20 of about 8,939 (157)

Effects of multiple doses of montmorillonite, alone and in combination with activated charcoal, on the toxicokinetics of a single dose of digoxin in rats [PDF]

Iranian Journal of Basic Medical Sciences, 2023
Objective(s): A narrow margin between the therapeutic and toxic doses of digoxin can result in an increased incidence of toxicity.  Since digoxin has an enterohepatic cycle, multiple oral doses of absorbents like montmorillonite may be useful in the ...
Fatemeh Heydarian, Mohamad Moshiri, Ali Roohbakhsh, Maryam Akaberi, Atoosa Haghighizadeh, Ameneh Ghadiri, Negar Yeganeh Khorasani, Leila Etemad   +7 more
doaj   +1 more source

Ten Years of Experience in Treating Patients With Digoxin Toxicity Without Using Digoxin Fab Antibody

International Journal of Medical Toxicology and Forensic Medicine, 2021
Background: Digoxin is extensively prescribed for cardiac diseases, so its chronic or acute toxicity commonly occur. Although digoxin specific antibodies (anti-digoxin Fab) are recommended to be used in patients with cardiac ...
Farzad Gheshlagh, Anselm Wong, Gholamali Dorooshi, Rokhsareh Meamar, Faezeh Tabesh, Hajar Aminsafaei, Shafeajafar Zoofaghari, Nastaran Eizadi-Mood   +7 more
doaj   +1 more source

Drug therapy monitoring (TDM) of Digoxin: safety and efficacy review [PDF]

Pharmacia, 2022
Digoxin was developed as a novel medication for the treatment of heart failure and atrial fibrillation (AF) 200 years ago. This investigation began with a PubMed and Google Scholar search for various papers using the terms digoxin safety and efficacy ...
Rony Abdi Syahputra, Urip Harahap, Aminah Dalimunthe, M. Pandapotan Nasution, Denny Satria   +4 more
doaj   +3 more sources

Review: Failure of current digoxin monitoring for toxicity: new monitoring recommendations to maintain therapeutic levels for efficacy

Frontiers in Cardiovascular Medicine, 2023
The current recommendations for monitoring digoxin, a narrow therapeutic index drug, are limited to confirming medication use or investigating suspicion of toxicity and fail our oath to do no harm.
Sridhar Rao Gona, Joel Rosenberg, Ria C. Fyffe-Freil, Janet M. Kozakiewicz, Mary E. Money, Mary E. Money   +5 more
doaj   +1 more source

Utilization of Digoxin among Hospitalized Older Patients with Heart Failure and Atrial Fibrillation in Thailand: Prevalence, Associated Factors, and Clinical Outcomes [PDF]

Annals of Geriatric Medicine and Research, 2021
Background Digoxin is used to control heart rate in patients with heart failure (HF) and atrial fibrillation (AF). However, its use is often limited in older patients, as they are prone to digoxin toxicity. This study aimed to determine the prevalence of
Noppaket Singkham, Yuttana Wongsalap, Duangkamon Poolpun, Sirichok Phetnoo, Chuthalak Somkhon   +4 more
doaj   +1 more source

Serum digoxin concentrations in dogs with atrial fibrillation under long term digoxin treatment [PDF]

Open Veterinary Journal, 2022
Background: Atrial fibrillation (AF) is the most common arrhythmia in dogs, most frequently diagnosed as chronic AF associated with a structural heart disease.
Antonella Colella, Serena Digiaro, Marco Fiorentino, Beatrice Greco, Mariateresa Sasanelli, Paola Paradies   +5 more
doaj   +1 more source

Safety profile of intravenous digoxin in Chinese patients with acute heart failure with reduced ejection fraction: a small-scale prospective cohort study

Frontiers in Pharmacology, 2023
Background: Adverse effects of intravenous digoxin vary from patients and disease status, which should be closely monitored.Aims: To explore the safety profile of intravenous digoxin in acute heart failure with reduced ejection fraction (HFrEF) among ...
Xintian Liu, Xintian Liu, Haojie Zhang, Wenlin Cheng, Qingkun Fan, Zhibing Lu, Xuan Zheng, Gangcheng Zhang   +7 more
doaj   +1 more source

Clinical signs and symptoms of toxic serum digoxin levels in neonates

The Turkish Journal of Pediatrics, 2019
Digoxin is widely used in the treatment of congestive heart failure and some arrhythmias. Digoxin toxicity may occur easily because digoxin has a narrow therapeutic index.
Mehmet Mutlu, Yakup Aslan, Şebnem Kader, Filiz Aktürk-Acar, Embiya Dilber   +4 more
doaj   +1 more source

The effect of calcium in water hardness on digoxin plasma levels in an experimental rat model [PDF]

ARYA Atherosclerosis, 2020
BACKGROUND: Digoxin is a drug for ventricular rate control in atrial fibrillation (AF). The major challenge in digoxin therapy is to adjust the appropriate concentration range for this drug due to its narrow therapeutic index.
Shabnam Shahsavand, Mohammad Moshirfar, Seyed Hassan Seyed-Sharifi, Mohammad Amin Younessi-Heravi, Reza Ghasemi, Morteza Valaei, Mohsen Yaghubi   +6 more
doaj   +1 more source

Electrophysiologic similarities of overdose between digoxin and bufadienolides found in a Chinese aphrodisiac

Journal of Arrhythmia, 2017
Classically derived from toad venom, bufadienolides are a group of cardioactive steroids with properties similar to digoxin. Some traditional Chinese medications, including several aphrodisiacs, contain bufadienolides.
Maxwell Bressman, Daniel Repplinger, William Slater, Mitchell Patt   +3 more
doaj   +1 more source