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Synthesis of cyclic di-nucleotidic acids as potential inhibitors targeting diguanylate cyclase
Bioorganic & Medicinal Chemistry, 2010Five analogs of cyclic di-nucleotidic acid including c-di-GMP were synthesized and evaluated for their biological activities on Slr1143, a diguanylate cyclase of Synechocystis sp. Slr1143 was overexpressed from the recombinant plasmid which contained the gene of interest and subsequently purified by affinity chromatography. A new HPLC method capable of
Ching, S.M. +3 more
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Enzymatic Production of c-di-GMP Using a Thermophilic Diguanylate Cyclase
2017C-di-GMP has emerged as a prevalent bacterial messenger that controls a multitude of bacterial behaviors. Having access to milligram or gram quantities of c-di-GMP is essential for the biochemical and structural characterization of enzymes and effectors involved in c-di-GMP signaling.
Prabhadevi, Venkataramani +1 more
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ASSESSMENT OF A PREDICTED DIGUANYLATE CYCLASE IN TREPONEMA DENTICOLA
2018VCU Theses and ...
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Intact and Degenerate Diguanylate Cyclases regulateShigellaCyclic di-GMP
AbstractThe intracellular human pathogenShigellainvades the colonic epithelium to cause disease. Prior to invasion, this bacterium navigates through different environments within the human body, including the stomach and the small intestine. To adapt to changing environments,Shigellauses the bacterial second messenger c-di-GMP signaling system ...Ruchi Ojha +3 more
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Biochemical characterization of blue light-regulated LOV-diguanylate cyclases
2018openaire +1 more source
Molecular mechanisms of signal integration in blue light-regulated diguanylate cyclases
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