Molecular Docking-Based Virtual Screening of FDA-Approved Drugs Using Trypanothione Reductase Identified New Trypanocidal Agents [PDF]
MoleculesAmerican trypanosomiasis or Chagas disease, caused by Trypanosoma cruzi (T. cruzi), affects approximately 6–7 million people worldwide. However, its pharmacological treatment causes several uncomfortable side effects, causing patients’ treatment ...
Rogelio Gómez-Escobedo +9 more
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Dihydroergotamine and triptan use to treat migraine during pregnancy and the risk of adverse pregnancy outcomes [PDF]
Scientific Reports, 2021 Migraine is prevalent during pregnancy. Antimigraine medications such as dihydroergotamine (DHE) and triptans have been associated with adverse pregnancy outcomes in individual studies but lack of consensus remains.
Anick Bérard +4 more
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Exploring optimal drug targets through subtractive proteomics analysis and pangenomic insights for tailored drug design in tuberculosis [PDF]
Scientific ReportsTuberculosis (TB), caused by Mycobacterium tuberculosis, ranks among the top causes of global human mortality, as reported by the World Health Organization’s 2022 TB report. The prevalence of M.
Muhammad Fayaz Khan +8 more
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Functional characterization of angiogenesis genes in hepatocellular carcinoma via integrated bulk and single cell RNA sequencing [PDF]
Scientific ReportsHepatocellular carcinoma (HCC) originates from hepatocytes and accounts for over 80% of primary liver cancers. Despite numerous studies have explained the role of certain angiogenesis-related and integrated stress response related genes in the ...
Jiayi Zhang +8 more
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Do antithrombotic drugs have a role in migraine prevention? A systematic review. [PDF]
HeadacheAbstract Objectives To explore the available evidence on the role of antithrombotics as migraine preventive medication. Background In clinical practice, the use of antithrombotic drugs in individuals with migraine is sometimes considered, especially in the case of frequent auras, association with patent foramen ovale, or prothrombotic states.
De Santis F +7 more
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Identifying potential drug targets in the kinomes of two monogenean species [PDF]
HelminthologiaProtein kinases are enzymes involved in essential biological processes such as signal transduction, transcription, metabolism, and the cell cycle. Human kinases are targets for several drugs approved by the US Food and Drug Administration. Therefore, the
Caña-Bozada V. H. +4 more
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Anti-migraine medications safety during pregnancy in the US [PDF]
Frontiers in PharmacologyBackgroundSpecific antimigraine medications (dihydroergotamine (DHE), triptans) have been associated with adverse pregnancy outcomes in individual studies but lack of consensus remains.ObjectivesQuantify the risk of prematurity, low birth weight (LBW ...
A. Bérard +5 more
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Targeting the Spike: Repurposing Mithramycin and Dihydroergotamine to Block SARS-CoV‑2 Infection [PDF]
ACS Omega, 2023 Soledad Stagnoli +10 more
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Citrullination modulation stabilizes HIF-1α to promote tumour progression [PDF]
Nature CommunicationsCitrullination plays an essential role in various physiological or pathological processes, however, whether citrullination is involved in regulating tumour progression and the potential therapeutic significance have not been well explored.
Rui Chen +12 more
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