A cuproptosis-related gene expression signature predicting clinical prognosis and immune responses in intrahepatic cholangiocarcinoma detected by single-cell RNA sequence analysis [PDF]
Cancer Cell InternationalBackground Cholangiocarcinoma represents a malignant neoplasm originating from the hepatobiliary tree, with a subset of tumors developing inside the liver.
Hefei Ren +9 more
doaj +2 more sources
Calcitriol Administration Attenuates Acute Lung Injury by Improving Angiopoietin/Tie2 Dysregulation and Alveolar-Capillary Barrier Integrity in a Mouse Model of Ovariectomy Complicated With Sepsis. [PDF]
Mediators InflammMenopause is associated with excessive weight, increased systemic inflammation, and oxidative stress. Menopause with obesity may aggravate the severity of organ damage when complicated with sepsis. This study investigated the impacts of calcitriol on acute lung injury (ALI)‐associated angiopoietin (Ang)/tyrosine kinase with immunoglobulin‐like and ...
Yeh CL +13 more
europepmc +2 more sources
A comparison of the large-scale gene expression patterns in summer and fall migratory Pantala flavescens (Fabricius) in northern China. [PDF]
Ecol EvolPantala flavescens (Fabricius) is the most well‐known seasonal migratory insect. A total of 624 differentially expressed genes (DEGs) with log2FC ≥ 2 were identified in summer migration compared to fall migration. Enrichment analysis showed that immunity, bacterial response and detoxification substances were significantly enriched in summer migration ...
Cao L, Wang N.
europepmc +2 more sources
A Cuproptosis-Related lncRNA Signature Predicts Prognosis and Shapes the Immune Landscape in Primary Lower-Grade Glioma. [PDF]
Genet Res (Camb)Glioma represents the most prevalent intracranial neoplasms. Lower‐grade gliomas (LGGs) are an important subtype of glioma, but the risk stratification of LGG has not been fully elucidated. As a recently recognized form of programmed cell death, cuproptosis is intimately tied to mitochondrial metabolism.
Wang M +5 more
europepmc +2 more sources
Structure of the cubic core and the lipoamide dehydrogenase component of the pyruvate dehydrogenase complex. [PDF]
, 1992 In this thesis, the crystal structures of the E3 component and of the catalytic domain of E2p are presented. These are the first atomic structures of the cubic core and of the E3 component of the pyruvate dehydrogenase and related multienzyme complexes ...
Mattevi, Andrea
core +9 more sources
Protein thiol modifications visualized in vivo. [PDF]
PLoS Biology, 2004 Thiol-disulfide interconversions play a crucial role in the chemistry of biological systems. They participate in the major systems that control the cellular redox potential and prevent oxidative damage.
Lars I Leichert, Ursula Jakob
doaj +1 more source
Identification of PDHX as a metabolic target for esophageal squamous cell carcinoma
Cancer Science, Volume 112, Issue 7, Page 2792-2802, July 2021., 2021 Inoue et al. found that pyruvate dehydrogenase (PDH) component X expression is necessary for PDH activity and is involved in the cancer stemness of esophageal squamous cell carcinoma (ESCC) cells, thereby being metabolically essential for the tumor growth of ESCC.
Jun Inoue +5 more
wiley +1 more source
Formation of reactive oxygen species by human and bacterial pyruvate and 2- oxoglutarate dehydrogenase multienzyme complexes reconstituted from recombinant components [PDF]
, 2015 Individual recombinant components of pyruvate and 2-oxoglutarate dehydrogenase multienzyme complexes (PDHc, OGDHc) of human and Escherichia coli (E. coli) origin were expressed and purified from E. coli with optimized protocols.
Adam-Vizi +123 more
core +1 more source