Advanced Science, Volume 12, Issue 4, January 27, 2025.An intelligent biomimetic nanomedicine is synthesized by camouflaging lung cancer cell membranes onto glucose oxidase‐loaded Cu‐LDHs (CMGCL) for cancer metabolism targeted interference. The CMGCL can achieve great tumor targeting efficacy and upregulate programmed death ligand‐1 (PD‐L1) expression on LLC cells by simultaneously inducing glucose ...
Yiming Xu +6 more
wiley +1 more source
Separation of protein X from the dihydrolipoyl transacetylase component of the mammalian pyruvate dehydrogenase complex and the study of protein X [PDF]
, 1989 Call number: LD2668 .T4 BICH 1989 P69Master of ScienceBiochemistry and Molecular Biophysics Interdepartmental ...
Powers-Greenwood, Susan L.
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Diabetes, Obesity and Metabolism, Volume 26, Issue 11, Page 4830-4845, November 2024.Abstract Non‐alcoholic fatty liver disease (NAFLD), a metabolic‐associated fatty liver disease, has become the most common chronic liver disease worldwide. Recently, the discovery of cuproptosis, a newly identified mode of cell death, further highlighted the importance of copper in maintaining metabolic homeostasis. An increasing number of studies have
Wangjing Tan +6 more
wiley +1 more source
Why are the 2-oxoacid dehydrogenase complexes so large? Generation of an active trimeric complex [PDF]
, 2014 The four-component polypeptides of the 2-oxoacid dehydrogenase complex from the thermophilic archaeon Thermoplasma acidophilum assemble to give an active multienzyme complex possessing activity with the branched-chain 2-oxoacids derived from leucine ...
Crennell, Susan +6 more
core +1 more source
Advanced Science, Volume 11, Issue 35, September 18, 2024.Mitochondria‐targeted core–shell nanoparticle Cu/TI for simultaneous cuproptosis induction and PD‐L1 downregulation is reported. Cu/TI exhibits prolonged blood circulation and high tumor uptake to induce immunogenic cancer cell death and reduce PD‐L1 expression in vivo, thereby effectively enhancing the infiltration and activation of cytotoxic T ...
Youyou Li +3 more
wiley +1 more source
Structure/function relationships in the pyruvate dehydrogenase complex form Azotobacter vinelandii [PDF]
European Journal of Biochemistry, 1993 The role of the hinge region between the binding domain and the catalytic domain in dihydrolipoyl transacetylase (E2p) from Azotobacter vinelandii was addressed by deletion mutagenesis. Mutated dihydrolipoyl transacetylase proteins were constructed with a deletion of 11 amino acids in the hinge region between the binding domain and the N‐terminal part ...
Schulze, E. +3 more
openaire +3 more sources
Studies on the structure and function of pyruvate dehydrogenase complexes [PDF]
, 1978 The aim of the present investigation was to obtain more information of the structure and function of the pyruvate dehydrogenase complexes from Azotobacter vinelandii and Escherichia coli.In chapter 2 a survey is given of the recent literature on pyruvate
Abreu, R., de
core +1 more source
Characterization of a Lipoyl Domain-independent B-cell Autoepitope on the Human Branched-chain Acyltransferase in Primary Biliary Cirrhosis and Overlap Syndrome with Autoimmune Hepatitis [PDF]
, 2003 Background and aims: Antimitochondrial antibodies (AMA) which recognize pyruvate acetyltransferase (PDC-E2) represent a highly diagnostic feature of primary biliary cirrhosis (PBC).
Csepregi, Antal +9 more
core +3 more sources
Cuproptosis: potential new direction in diabetes research and treatment. [PDF]
Front Endocrinol (Lausanne)Cuproptosis, a recently discovered form of cell death, stems from an overabundance of copper ions infiltrating mitochondria. These ions directly engage lipoylated proteins, prompting their oligomerization and subsequent loss of iron-sulfur clusters. This
Qu J, Wang Y, Wang Q.
europepmc +3 more sources
Properties of a newly characterized protein of the bovine kidney pyruvate dehydrogenase complex [PDF]
, 1985 Call number: LD2668 .T4 1985 J54Master of ...
Jilka, Joseph M.
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