, 2004 Intracellular symbiosis is very common in the insect world. For the aphid Cinara cedri, we have identified by electron microscopy three symbiotic bacteria that can be characterized by their different sizes, morphologies, and electrodensities.
García-Verdugo, José Manuel +6 more
core +2 more sources
Structural interrogation of enzyme mechanism and dynamics [PDF]
, 2023 The pyruvate dehydrogenase complex (PDHc) is one of the largest macromolecular enzyme complexes, and serves an universally important metabolic function by converting pyruvate into acetyl-CoA.
Mehr, Alexander
core +1 more source
Diabetes, Obesity and Metabolism, Volume 26, Issue 11, Page 4830-4845, November 2024.Abstract Non‐alcoholic fatty liver disease (NAFLD), a metabolic‐associated fatty liver disease, has become the most common chronic liver disease worldwide. Recently, the discovery of cuproptosis, a newly identified mode of cell death, further highlighted the importance of copper in maintaining metabolic homeostasis. An increasing number of studies have
Wangjing Tan +6 more
wiley +1 more source
Why are the 2-oxoacid dehydrogenase complexes so large? Generation of an active trimeric complex [PDF]
, 2014 The four-component polypeptides of the 2-oxoacid dehydrogenase complex from the thermophilic archaeon Thermoplasma acidophilum assemble to give an active multienzyme complex possessing activity with the branched-chain 2-oxoacids derived from leucine ...
Crennell, Susan +6 more
core +1 more source
Characterization of a Lipoyl Domain-independent B-cell Autoepitope on the Human Branched-chain Acyltransferase in Primary Biliary Cirrhosis and Overlap Syndrome with Autoimmune Hepatitis [PDF]
, 2003 Background and aims: Antimitochondrial antibodies (AMA) which recognize pyruvate acetyltransferase (PDC-E2) represent a highly diagnostic feature of primary biliary cirrhosis (PBC).
Csepregi, Antal +9 more
core +3 more sources
Elesclomol Loaded Copper Oxide Nanoplatform Triggers Cuproptosis to Enhance Antitumor Immunotherapy
Advanced Science, Volume 11, Issue 18, May 15, 2024.A copper oxide (CuO)‐based and copper ionophore elesclomol (ES)‐loaded nanoplatform (denoted ES@CuO) is designed to trigger immunogenic cell death via cuproptosis. Meanwhile, combined therapy with ES@CuO nanoparticles and PD‐1 synergistically remodels the immunosuppressive tumor microenvironment to significantly inhibit the growth of murine melanoma ...
Xufeng Lu +17 more
wiley +1 more source
Separation of protein X from the dihydrolipoyl transacetylase component of the mammalian pyruvate dehydrogenase complex and the study of protein X [PDF]
, 1989 Call number: LD2668 .T4 BICH 1989 P69Master of ScienceBiochemistry and Molecular Biophysics Interdepartmental ...
Powers-Greenwood, Susan L.
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A Brief Review on Manipulation of Essential Metal Ions as Nanomedicine for Cancer Therapy
Advanced NanoBiomed Research, Volume 4, Issue 2, February 2024.In this review, the latest progression of essential metal‐ion‐based nanomedicine for tumor therapy is summarized, existing challenges are addressed, and possible directions of such therapeutic strategies are proposed. Such information benefits readers a general awareness for current research status and implication of the future clinical applications ...
Lin Weng, Xin Chen
wiley +1 more source
Studies on the structure and function of pyruvate dehydrogenase complexes [PDF]
, 1978 The aim of the present investigation was to obtain more information of the structure and function of the pyruvate dehydrogenase complexes from Azotobacter vinelandii and Escherichia coli.In chapter 2 a survey is given of the recent literature on pyruvate
Abreu, R., de
core +1 more source
Properties of a newly characterized protein of the bovine kidney pyruvate dehydrogenase complex [PDF]
, 1985 Call number: LD2668 .T4 1985 J54Master of ...
Jilka, Joseph M.
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