Elesclomol Loaded Copper Oxide Nanoplatform Triggers Cuproptosis to Enhance Antitumor Immunotherapy
Advanced Science, Volume 11, Issue 18, May 15, 2024.A copper oxide (CuO)‐based and copper ionophore elesclomol (ES)‐loaded nanoplatform (denoted ES@CuO) is designed to trigger immunogenic cell death via cuproptosis. Meanwhile, combined therapy with ES@CuO nanoparticles and PD‐1 synergistically remodels the immunosuppressive tumor microenvironment to significantly inhibit the growth of murine melanoma ...
Xufeng Lu +17 more
wiley +1 more source
The pyruvate and α-ketoglutarate dehydrogenase complexes of Pseudomonas aeruginosa catalyze pyocyanin and phenazine-1-carboxylic acid reduction via the subunit dihydrolipoamide dehydrogenase [PDF]
, 2017 Phenazines are a class of redox-active molecules produced by diverse bacteria and archaea. Many of the biological functions of phenazines, such as mediating signaling, iron acquisition, and redox homeostasis, derive from their redox activity.
Glasser, Nathaniel R. +3 more
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A Brief Review on Manipulation of Essential Metal Ions as Nanomedicine for Cancer Therapy
Advanced NanoBiomed Research, Volume 4, Issue 2, February 2024.In this review, the latest progression of essential metal‐ion‐based nanomedicine for tumor therapy is summarized, existing challenges are addressed, and possible directions of such therapeutic strategies are proposed. Such information benefits readers a general awareness for current research status and implication of the future clinical applications ...
Lin Weng, Xin Chen
wiley +1 more source
Identification of miRNAs involved in pear fruit development and quality [PDF]
, 2014 BACKGROUND: MicroRNAs (miRNAs) are a class of small, endogenous RNAs that take part in regulating genes through mediating gene expressions at the post-transcriptional level in plants.
Defu Wang +5 more
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Human skeletal muscle pyruvate dehydrogenase phosphatase activity and expression : the effect of aerobic capacity [PDF]
, 2009 Activation of pyruvate dehydrogenase (PDH), which converts pyruvate into acetyl-CoA, is accomplished by a pair of specific phosphatases (PDP 1 & 2). A cross-sectional study investigating the effect of aerobic capacity on PDP activity and expression ...
Love, Lorenzo Kenward.
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Molecular architecture of the human pyruvate dehydrogenase complex [PDF]
, 2006 Mammalian pyruvate dehydrogenase multi-enzyme complex (PDC) is a key metabolic assembly responsible for the maintenance of glucose homeostasis. PDC comprises a central pentagonal dodecahedral core of 60 dihydrolipoamide acetyltransferase (E2) and 12 E3 ...
Smolle, Michaela
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Solution structures of lipoyl domains of the 2-oxo acid dehydrogenase complexes from Azotobacter vinelandii : implications for molecular recognition [PDF]
, 1997 The 2-oxo acid dehydrogenase complexes are large multienzyme complexes that catalyse the irreversible oxidative decarboxylation of a specific 2-oxo acid to the corresponding acyl-CoA derivative.
Berg, A.
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The Journal of biological chemistry, 1989 We have further distinguished the structures and roles of the two lipoyl-bearing components of the pyruvate dehydrogenase complex, the dihydrolipoyl transacetylase (E2) component and the component designated as protein X. The amino acid sequences of the NH2-terminal regions of the lipoyl-bearing domain of the E2 component and protein X are different ...
M, Rahmatullah +5 more
openaire +2 more sources
Studies on the mammalian pyruvate dehydrogenase complex: pyruvate dehydrogenase kinase binding sites, reductive acetylation reaction and extrinsic control [PDF]
, 1989 Call number: LD2668 .T4 BICH 1989 L5Master of ScienceBiochemistry and Molecular Biophysics Interdepartmental ...
Li, Lin.
core
Engineering of escherichia coli 2-oxoglutarate dehydrogenase complex with mechanistic and synthetic goals [PDF]
, 2019 The Escherichia coli 2-oxoglutarate dehydrogenase complex (OGDHc) compromises multiple copies of three enzymes - 2-oxoglutarate dehydrogenase (E1o), dihydrolipoyl succinyltransferase (E2o), and dihydrolipoyl dehydrogenase (E3).
Chakraborty, Joydeep
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