Results 331 to 340 of about 24,273 (376)
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Melanin Polymerization Held in Check: A Composite of Dihydroxyphenylalanine with Zeolite Beta
, 2015The potential use of l-3,4-dihydroxyphenylalanine (l-DOPA) amino acid in the treatment of Parkinson’s disease is hindered by an oxidative polymerization under air that might be at least partially circumvented by the immobilization on an inorganic matrix.
Meryem Bouchoucha +7 more
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Binding studies of L-3,4-dihydroxyphenylalanine with human serum albumin.
Molecular Biosystems, 2014L-Dopa has been used to increase dopamine concentrations in the treatment of Parkinson's disease and dopamine-responsive dystonia. The binding interaction between L-dopa (phytochemical) and human serum albumin (HSA) under simulated physiological ...
D. P. Yeggoni, R. Subramanyam
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Enzymatic decarboxylation of isomers and derivatives of dihydroxyphenylalanine
Archives of Biochemistry and Biophysics, 1952Abstract 1. 1. The substrate specificities of tyrosine decarboxylase of Streptococcus faecalis R and of dihydroxyphenylalanine (DOPA) decarboxylase of pig and guinea pig kidney have been studied. 2. 2. The quantitative data reveal that interaction between substituents on the benzene ring of the substrates, as well as the position of the ...
T. L. Sourkes +2 more
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The metabolism of L-3,4-dihydroxyphenylalanine in man
Clinica Chimica Acta, 1970Abstract This study describes the metabolic fate of orally ingested l -3,4-dihydroxy-phenylalanine in four human adults. The amounts of L-DOPA ingested ranged from 3 to 8 g per day. A variety of techniques were employed whereby the acid, amine, and neutral urinary metabolites were determined.
L.R. Gjessing +3 more
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3, 4-Dihydroxyphenylalanine and Related Compounds
1966This review covers essentially derivatives of β-phenyl-α-alanine which contain two phenolic hydroxyl groups, and some of their analogs and derivatives. They comprise β-(3, 4-dihydroxyphenyl)-α-alanine (dopa) and the few known ethers and ring substituted derivatives of this amino acid, as well as derivatives of dopa substituted in the alanine group ...
A. R. Patel, Alfred Burger
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Journal of Neurochemistry, 1981
Abstract: We have investigated the effects of 3,4‐dihydroxyphenylalanine l‐DOPA) and its deuterated analogue on the concentrations of alcoholic metabolites of catecholamines in rat brain by means of gas chromatography/mass spectrometry with selected‐ion monitoring.
David J. Edwards, Marguerite Rizk
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Abstract: We have investigated the effects of 3,4‐dihydroxyphenylalanine l‐DOPA) and its deuterated analogue on the concentrations of alcoholic metabolites of catecholamines in rat brain by means of gas chromatography/mass spectrometry with selected‐ion monitoring.
David J. Edwards, Marguerite Rizk
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Electroencephalographic analysis of the central action of dihydroxyphenylalanine
Electroencephalography and Clinical Neurophysiology, 1970Abstract 1. 1. The EEG effects of DOPA were analysed in cats, depending upon the level of brain-stem section. 2. 2. In contrast with cats with chronically implanted electrodes, gallamine-immobilized, and with encephale isole cats, in which DOPA is unable to induce profound changes in the EEG pattern and behaviour, this amino acid elicits an
K Kadzielawa, E Widy-Tyszkiewicz
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L-Dihydroxyphenylalanine: Effect on S -Adenosylmethionine in Brain
Science, 1970Forty-five minutes after intraperitoneal injection of a single dose (100 milligrams per kilogram) of L-dihydroxyphenylalanine, the concentration of S -adenosylmethionine in rat brain was lowered by 76 percent. As little as 10 milligrams of L-dihydroxyphenylalanine per kilogram decreased content of S
Ross J. Baldessarini +4 more
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The action of L‐dihydroxyphenylalanine in patients receiving nialamide
Clinical Pharmacology & Therapeutics, 1965Nialamide produces effective monamine oxidase inhibition resulting in a three‐ to fivefold increase in tryptamine excretion when administered in a dose of 100 mg. for 10 days. L‐Dihydroxyphenylalanine, given in a dose of 75 to 100 mg. to normal volunteers receiving nialamide in a dose of 100 mg.
Nathan S. Kline +2 more
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Metabolism of Dihydroxyphenylalanine in Human Subjects
Nature, 1967THE metabolism of dihydroxyphenylalanine (DOPA; I, R = H) may be very complex. By analogy with other amino-acids, degradation may involve decarboxylation (route A) or transamination (route B), with methylation of the 3-hydroxy group possible at any stage. The principal metabolite in normal human urine appears to be homovanillic acid (HVA; III, R = CH3),
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