Results 181 to 190 of about 49,544 (290)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, Volume 20, Issue 11, Page 2741-2763, November 2026.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Philosophie DIY

Philosophie DIY Exemples ➢ Une fois conçu, on peut partager notre travail pour faciliter le travail des collègues. Il y a quelques règles à respecter. -Trouver la bonne licence. Les licences de plus en plus utilisées sont des licences Creative Commons. Ces licences sont gratuites et relativement simples, mais il y a plusieurs variantes.
Zawilski, B, Bustillo, V
openaire   +1 more source

GDNF‐Enriched Small Extracellular Vesicle‐Loaded ROS‐Scavenging Hydrogel Promotes Neural Regeneration After Spinal Cord Injury

Advanced Healthcare Materials, Volume 15, Issue 41, 6 November 2026.
A glial cell line‐derived neurotrophic factor (GDNF)‐enriched small extracellular vesicle‐loaded reactive oxygen species (ROS)‐scavenging hydrogel integrates sustained neurotrophic delivery with local modulation of oxidative and inflammatory stress after spinal cord injury. The composite hydrogel improves local vesicle retention, protects neural tissue,
Xingyu Zhu, Zhong Liu, Kewei Li, Yuhong Fan, Kangjia Yang, Xiaopeng Sun, Hang Shi, Lixuan Sun, Yang Lou, Min Wang, Peipei Wu, Hui Qian, Qiang Fu, Hua Ding   +13 more
wiley   +1 more source

Comparative associations of six predefined dietary patterns with site-specific cancer risk in the UK Biobank. [PDF]

Front Nutr
Gao L, Feng P, Shi G, Li Y, Ma B, Zhang C, Chen Y, Li S, Hu J, Wang L, Yan X, Shen P, Cao X, Wu B.   +13 more
europepmc   +1 more source

Repurposing a Small Molecule Plant Hormone as a Tunable ON‐Switch for CAR‐T Cell Immunotherapy

Advanced Science, Volume 13, Issue 61, 3 November 2026.
By engineering a receptor system integrating the plant auxin receptor AFB1 with its co‐receptor IAA7, we enable ligand‐dependent interactions triggered by the plant hormone auxins. This design allows rapid, reversible, and dose‐dependent T cell activation, resulting in potent cytotoxicity against B‐cell lymphoma in vitro and in vivo.
Hongxiang Zeng, Lei Zheng, Rongkun Tao, Sirui Zheng, Yanke Zhong, Yongxia Niu, Peng Zhang, Xiang Ma, Chen Yang, Min Zhang, Fuyu Duan, Jing Yang, Xuan Wei, Xiang Zhou, Zhenbiao Yang, Zhaoxi Sun, Qizhou Lian   +16 more
wiley   +1 more source

Perceived Racial Discrimination Is Associated with Greater Dietary Inflammatory Potential in Children and Adolescents in the Adolescent Brain and Cognitive Development Study. [PDF]

Curr Dev Nutr
Tembo P, Moore TR, Affuso O, Cuevas AG, Aidoo R, Wirth MD, Hébert JR, Krobath DM.   +7 more
europepmc   +1 more source

Responsive Membrane Antenna Enables Adaptive Biohybrid Interface for Photosynthesis Promotion, Stress Reporting and Modulation

Advanced Science, Volume 13, Issue 61, 3 November 2026.
An environmentally responsive antenna assembled onto the algal cell membrane creates a biohybrid with a responsive interface that promotes photosynthesis under normal conditions and shifts to H2O2‐triggered stress reporting and modulation upon stress onset, boosting environmental sensing and adaptive response.
Bing Liu, Gongmeiyue Su, Jingyi Shi, Hang Yao, Yuchun Han, Zhao Li, Chengcheng Zhou   +6 more
wiley   +1 more source

Nano Proton Scavengers Modulate Endosomal pH to Inhibit Microglial Activation and Enhance Stroke Recovery

Advanced Science, Volume 13, Issue 62, 9 November 2026.
Amphiphilic sulfonated chitosan nanoparticles buffer endo/lysosomal acidity in microglia by limiting V‐ATPase membrane recruitment and restoring endosomal homeostasis. Following systemic administration, they accumulate in the ischemic hemisphere partly through association with infiltrating immune cells, suppress TLR3/IRF3 and TLR4/NF‐κB signaling ...
Xuanlin Wang, Yujing Shi, Zehua Gao, Jing Wang, Changsheng Liu   +4 more
wiley   +1 more source

Targeting the NR1D1–IGF2BP2–V‐ATPase Axis With Hybrid Nanovesicles Restores Macrophage Rhythms to Reverse Sepsis‐Induced Immunosuppression

Advanced Science, Volume 13, Issue 62, 9 November 2026.
Sepsis disrupts immune‐cell rhythms and weakens bacterial clearance. Biomimetic nanovesicles combining erythrocyte and inflammation‐activated macrophage membranes deliver siNR1D1 to dysfunctional macrophages, restoring the NR1D1–IGF2BP2–V‐ATPase pathway, circadian regulation, phagolysosomal acidification, and antimicrobial defense.
Lang Chen, Wenyi Lin, Lang Jiang, Xuehui Gao, Chenyan Yu, Jili Han, Zhenping Liu, Xuefeng Li, Mei He, Chang Li, Qilan Li, Chaoying Song, Jiqian Xu, You Shang   +13 more
wiley   +1 more source

Mediating roles of systemic immune-inflammation index and body mass index in the association between dietary inflammatory index and cardiovascular disease in diabetes. [PDF]

Medicine (Baltimore)
Tang S, Li H, Wang Z, Wang B, Li Z, Li Y, Dai C.   +6 more
europepmc   +1 more source