Results 41 to 50 of about 67,476 (263)

Tailoring Vascular‐Immune Homeostasis via Manganese‐DNA Complex‐Armed Immunogenic Extracellular Vesicles for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
This study demonstrates that Mn2⁺–tumor DNA complexes encapsulated in dendritic cell (DC)– derived immunogenic extracellular vesicles (EVDC@Mn‐DNA) act as a DC‐specific cGAS– STING activator. EVDC@Mn‐DNA treatment enhances intratumoral DC activation, improves tumor vascular function, promotes CD8⁺ T cell activity, and suppresses pancreatic tumor growth,
Xue Jiang, Lihuan Shang, Xiaochun Chen, Xiangzhan Kong, Xiaojuan Wang, Linjia Jiang, Huiying Zhao, Yafeng Zhu, Cheng Huang, Shiyi Deng, Rui Zhang, Minghui Wang, Haoming Lin, Ping‐Pui Wong   +13 more
wiley   +1 more source

Impact of agro-industrial by-products on nutritional value and microbiota composition of black soldier fly larvae

Frontiers in Microbiology
In this study, interrelations between agro-industrial by-products, black soldier fly larvae (BSFL) rearing, and associated microbiota were investigated.
Martina Kieβling, Thorben Sieksmeyer, Christian Hertel, Andreas Juadjur, Kemal Aganovic, Kemal Aganovic, Volker Heinz, Kashif ur Rehman, Kashif ur Rehman   +8 more
doaj   +1 more source

Decoding IGLL5 Mutation‐Mediated BCR Signaling: A Novel Mechanism of CD8+ T Cell Exhaustion and Ocular MALT Lymphoma Progression

Advanced Science, EarlyView.
OAML harbors recurrent IGLL5 mutations that reinforce CD79A/CD79B‐associated BCR signaling. Mechanistic analysis of the S47G and A54G variants reveals induction of CXCL10/CXCL11, enhanced CD8+ T‐cell recruitment, and exhaustion‐associated dysfunction, supporting an immune‐tolerant niche.
Andi Zhao, Haoyu Wei, Chenyu Zhou, Xinping Sun, Shuyan Da, Haiyu Liu, Zijin Wang, Hui Zhu, Shiya Shen, Qing Shao, Qi Gong, Hu Liu, Xuejuan Chen   +12 more
wiley   +1 more source

Targeting Supramolecular Active Complexes of Nav1.7/Nav1.8 to Relieve Chronic Neuropathic Pain

Advanced Science, EarlyView.
In mice and patients with severe chronic neuropathic pain (NP), Nav1.7, Nav1.8, TrkB, and five cytoskeletal proteins form supramolecular active complexes (SMACs) with polygonal lattice structures as noxious signal amplifiers in dorsal root ganglion (DRG) neurons.
Liting Sun, Hang Xian, Yunxin Shi, Taotan Yang, Hongyan Shuai, Wenchao Hu, Siying Fei, Miao Xu, Taoyuan Yang, Ruilong Xia, Ting Wen, Fengting Zhu, Yan Fu, Yang Li, Wei Xia, Ran Qian, Yuanying Liu, Zhicheng Tian, Lamei Li, Qian Zhou, Lize Xiong, Rui Cong, Ceng Luo, Shengxi Wu, Xiafeng Shen, Xin Yu, Rou‐Gang Xie, Changgeng Peng   +27 more
wiley   +1 more source

Türkiye Kentlerinin Kentleşme Düzeylerinin Demografik, Ekonomik ve Sosyal Değişkenlerle Belirlenmesi

Coğrafi Bilimler Dergisi, 2008
The fundamental economic restructuring driven by globalisation and the revolution in information and communication technology are the most important processes in our contemporary world.
M. Murat Yüceşahin, E. Murat Özgür
doaj   +1 more source

S100A14 in Tumor‐Derived EVs Targets PIAS3 to Reprogram Astrocytes and Induce Immunosuppressive Microenvironment Promoting Brain Metastasis and Germacrone Reversal Effect

Advanced Science, EarlyView.
This study identifies S100A14 in tumor‐derived exosomes as a key driver of brain metastasis. S100A14 targets PIAS3 in astrocytes, activating STAT3 signaling and promoting immunosuppressive MDSCs recruitment via chemokine secretion. Germacrone, a natural compound, binds S100A14 to disrupt this axis, effectively inhibiting brain metastasis with low ...
Qian Feng, Xia Yang, Lin An, Xue‐Yu Wang, Ming‐Rui Wang, Zhuo‐Hong Cai, Cai‐Jun Xie, Li‐Jun Qiao, You‐Bi Shen, Xi‐Min Liang, Rong Zhang, Cai‐Yan Wang, Zhong‐Qiu Liu, Rong‐Rong Zhang   +13 more
wiley   +1 more source

İngilizce Dinleme Etkinliklerinde Yaşanan Sorunların Dinleme Öncesi Dil Öğrenme Stratejileri İle Ele Alınması

, 2020
Dil öğrenen bireyler için dinleme becerisi, dört dil becerisi (dinleme, okuma, konuşma, yazma) arasında edinilmesi gereken en zor beceridir. Bu çalışmada Anadolu Lisesi 9.
Baysal , Emine Akkaş, Gürbüz OCAK, Emine AKKAŞ BAYSAL, Ocak, Gürbüz   +3 more
core   +1 more source

Ege Bölgesi’nde yağışın mekânsal dağılımı

Coğrafi Bilimler Dergisi, 2013
Spatial modelling of climatological variables is one of the most crucial parts of environmental studies. Prediction of natural events such as hydrological phenomenon, drought, flood, ground-surface water amount, pollution of water sources, and issues ...
Olgu Aydın, İhsan Çiçek
doaj   +1 more source

Microglia‐Targeted Biomimetic Tetrahedral Framework Nucleic Acid Nanovesicles for Synergistic Treatment of Sepsis‐Associated Encephalopathy

Advanced Science, EarlyView.
Sepsis‐associated encephalopathy (SAE) lacks effective therapies. We developed ME@FDsi, a biomimetic nanodrug using a tetrahedral framework nucleic acid to deliver disulfiram and siTNFα. It crosses the blood‐brain barrier, targets M1 microglia, inhibits pyroptosis and inflammation, and scavenges ROS.
Huimin Shi, Qiuxia Gao, Wenying Wang, Bin Li, Yukun Chen, Zhijun Yao, Yujie Li, Junrui Li, Na Li, Gong Gu, Zhimin Hou, Mengyuan Yang, Ruilin Zhang, Hongju Yang, Yuhui Liao, Hongyi Lei   +15 more
wiley   +1 more source

Türkçe Öğrenen Yabancıların Kullandıkları Dil Öğrenme Stratejileri

, 2020
Bu çalışmanın amacı, Ankara Üniversitesi Türkçe ve Yabancı Dil Uygulama ve Araştırma Merkezi TÖMER'de Türkçe öğrenen yabancı uyruklu öğrenicilerin dil öğrenme stratejilerini kullanma/tercih etme düzeylerinin belirlenmesi ve bu düzeylerin çeşitli ...
Alan, Sebahat, Peçenek, Dilek, Gökmen, M. Ertan, Özdemir, Hasan Fehmi   +3 more
core