Results 31 to 40 of about 1,590,882 (307)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

A Case of Esophageal Intramural Pseudodiverticulosis

Gut and Liver, 2011
Esophageal intramural pseudodiverticulosis (EIP) is a rare benign disease that is characterized by multiple tiny flaskshaped outpouching lesions of the esophageal wall. The etiology is unknown, but the pathologic fi ndings include dilatation of excretory
doaj   +1 more source

CHRONIC DUODENAL DILATATION [PDF]

Archives of Surgery, 1920
Chronic duodenal dilatation is a frequent pathologic condition. This assertion is based, not alone on clinical observations, but also on the well known anatomic faults of the adult human duodenum. Normally the human duodenum has practically no mesentery; it is fixed dorsally by an abundant retroperitoneum, is indented in front and behind by blood ...
openaire   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

THE DILATATION OF BRONCHIAL STRICTURES [PDF]

Journal of the American Medical Association, 1912
Bronchial stenoses may be divided into functional and organic. The organic stenoses comprise a number of widely different lesions, but it is only cicatricial stenosis that will be considered in this paper. The chief causes of cicatricial bronchial stenosis are traumatism, syphilis and tuberculosis; or perhaps more accurately, the secondary infections ...
openaire   +2 more sources

FBN1 polymorphisms in patients with the dilatative pathology of the ascending thoracic aorta [PDF]

European Journal of Cardio-Thoracic Surgery, 2015
To investigate polymorphisms of the fibrillin-1 (FBN1) gene (namely, rs2118181, rs1036477, rs10519177, rs755251 and rs4774517) in a case-control study for dilatative pathology of the ascending thoracic aorta (DPATA) from Lithuanians.We studied 312 patients who had undergone aortic reconstructive surgery for DPATA.
Lesauskaitė, Vaiva, Šepetienė, Ramunė, Jarienė, Giedrė, Patamsytė, Vaiva, Žukovas, Giedrius, Grabauskytė, Ingrida, Stanionienė, Zita, Širmenis, Raimondas, Benetis, Rimantas   +8 more
openaire   +3 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Understanding heterogeneous mechanisms of heart failure with preserved ejection fraction through cardiorenal mathematical modeling.

PLoS Computational Biology, 2023
In contrast to heart failure (HF) with reduced ejection fraction (HFrEF), effective interventions for HF with preserved ejection fraction (HFpEF) have proven elusive, in part because it is a heterogeneous syndrome with incompletely understood ...
Sanchita Basu, Hongtao Yu, Jonathan R Murrow, K Melissa Hallow   +3 more
doaj   +1 more source

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

Clinical characteristics, CT signs, and pathological findings of Pyrrolizidine alkaloids-induced sinusoidal obstructive syndrome: a retrospective study

BMC Gastroenterology, 2020
Background One major etiology of hepatic sinusoidal obstruction syndrome (HSOS) in China is the intake of pyrrolizidine alkaloids (PAs). Since PAs-induced HSOS is a rare disease that has not been clearly characterized until now, the aim of this study was
Fang Liu, Xinxin Rong, Hui Guo, Dong Xu, Chang Liu, Lingling Meng, Xiaoqian Yang, Tingting Guo, Xuefeng Kan, Yuhu Song   +9 more
doaj   +1 more source