Results 1 to 10 of about 591,365 (304)

Neonatal dilated cardiomyopathy

Revista Portuguesa de Cardiologia, 2017
Cardiomyopathies are rare diseases of the heart muscle, of multiple causes, that manifest with various structural and functional phenotypes but are invariably associated with cardiac dysfunction.
Paulo Soares, Gustavo Rocha, Susana Pissarra, Henrique Soares, Filipa Flôr-de-Lima, Sandra Costa, Cláudia Moura, Sofia Dória, Hercília Guimarães   +8 more
doaj   +4 more sources

Dilated cardiomyopathy [PDF]

Nature Reviews Disease Primers, 2019
Dilated cardiomyopathy (DCM) is a clinical diagnosis characterized by left ventricular or biventricular dilation and impaired contraction that is not explained by abnormal loading conditions (for example, hypertension and valvular heart disease) or ...
H. Schultheiss, D. Fairweather, A. Caforio, F. Escher, R. Hershberger, S. Lipshultz, Peter P. Liu, A. Matsumori, A. Mazzanti, J. Mcmurray, S. Priori   +10 more
semanticscholar   +9 more sources

Reevaluating the Genetic Contribution of Monogenic Dilated Cardiomyopathy

Circulation, 2020
Supplemental Digital Content is available in the text. Background: Dilated cardiomyopathy (DCM) is genetically heterogeneous, with >100 purported disease genes tested in clinical laboratories.
Francesco Mazzarotto, Upasana Tayal, Alicja Wilk   +2 more
exaly   +2 more sources

Natural genetic variation of the cardiac transcriptome in non-diseased donors and patients with dilated cardiomyopathy

Genome Biology, 2017
Background Genetic variation is an important determinant of RNA transcription and splicing, which in turn contributes to variation in human traits, including cardiovascular diseases. Results Here we report the first in-depth survey of heart transcriptome
Matthias Heinig, Michiel E. Adriaens, Sebastian Schafer, Hanneke W. M. van Deutekom, Elisabeth M. Lodder, James S. Ware, Valentin Schneider, Leanne E. Felkin, Esther E. Creemers, Benjamin Meder, Hugo A. Katus, Frank Rühle, Monika Stoll, François Cambien, Eric Villard, Philippe Charron, Andras Varro, Nanette H. Bishopric, Alfred L. George, Cristobal dos Remedios, Aida Moreno-Moral, Francesco Pesce, Anja Bauerfeind, Franz Rüschendorf, Carola Rintisch, Enrico Petretto, Paul J. Barton, Stuart A. Cook, Yigal M. Pinto, Connie R. Bezzina, Norbert Hubner   +30 more
doaj   +2 more sources

Association Between Midwall Late Gadolinium Enhancement and Sudden Cardiac Death in Patients With Dilated Cardiomyopathy and Mild and Moderate Left Ventricular Systolic Dysfunction

Circulation, 2017
Background: Current guidelines only recommend the use of an implantable cardioverter defibrillator in patients with dilated cardiomyopathy for the primary prevention of sudden cardiac death (SCD) in those with a left ventricular ejection fraction (LVEF ...
Brian P Halliday, Kaushik Guha, Simon Newsome   +2 more
exaly   +2 more sources

Infantile dilated cardiomyopathy caused by RPL3L gene mutation: A case report [PDF]

Journal of International Medical Research
Ribosomal protein L3-like gene mutations have been implicated in early-onset severe dilated cardiomyopathy (OMIM #115200). This report describes an infant with dilated cardiomyopathy resulting from RPL3L gene mutations. A 2-month-old girl was admitted in
Biwei Mai, Zhixian Lei, Shanqing Qin, Guidan Yang, Naiyun Zhu, Wanqian Lin   +5 more
doaj   +2 more sources

Precise genomic editing of pathogenic mutations in RBM20 rescues dilated cardiomyopathy

Science Translational Medicine, 2022
Mutations in RNA binding motif protein 20 (RBM20) are a common cause of familial dilated cardiomyopathy (DCM). Many RBM20 mutations cluster within an arginine/serine-rich (RS-rich) domain, which mediates nuclear localization. These mutations induce RBM20
Takahiko Nishiyama, Yu Zhang, Miao Cui, Hui Li, E. Sánchez-Ortiz, John R. McAnally, Wei Tan, Jiwoong Kim, Kenian Chen, Lin Xu, R. Bassel-Duby, E. Olson   +11 more
semanticscholar   +1 more source

A predictive model for canine dilated cardiomyopathy—a meta-analysis of Doberman Pinscher data [PDF]

PeerJ, 2015
Dilated cardiomyopathy is a prevalent and often fatal disease in humans and dogs. Indeed dilated cardiomyopathy is the third most common form of cardiac disease in humans, reported to affect approximately 36 individuals per 100,000 individuals.
Siobhan Simpson, Jennifer Edwards, Richard D. Emes, Malcolm A. Cobb, Nigel P. Mongan, Catrin S. Rutland   +5 more
doaj   +2 more sources

Understanding the genetics of adult-onset dilated cardiomyopathy: what a clinician needs to know.

European Heart Journal, 2021
There is increasing understanding of the genetic basis to dilated cardiomyopathy and in this review, we offer a practical primer for the practising clinician.
U. Tayal, J. Ware, N. Lakdawala, S. Heymans, S. Prasad   +4 more
semanticscholar   +1 more source

Mitochondrial Function and Dysfunction in Dilated Cardiomyopathy

Frontiers in Cell and Developmental Biology, 2021
Cardiac tissue requires a persistent production of energy in order to exert its pumping function. Therefore, the maintenance of this function relies on mitochondria that represent the “powerhouse” of all cardiac activities.
D. Ramaccini, Vanessa Montoya-Uribe, F. Aan, Lorenzo Modesti, Y. Potes, M. Wieckowski, I. Krga, M. Glibetić, P. Pinton, C. Giorgi, M. Matter   +10 more
semanticscholar   +1 more source