Results 171 to 180 of about 117,472 (257)
Pacing and Clinical Electrophysiology, EarlyView.ABSTRACT Background The role of cardiac resynchronization therapy (CRT) during hospitalization for heart failure (HFH) is uncertain, because hospitalized patients were routinely excluded from landmark CRT trials. Despite this, CRT implantation during HFH is common.
Oliver Rees +5 more
wiley +1 more source
Pacing and Clinical Electrophysiology, EarlyView.ABSTRACT Background/Objectives Right ventricular (RV) apical pacing, the standard pacing approach, often induces ventricular dyssynchrony, potentially impairing cardiac function. This study aims to investigate whether targeted RV septal pacing, guided by functional electrophysiological feedback during implantation, reduces ventricular dyssynchrony ...
Bianca Iulia Catrina +5 more
wiley +1 more source
Experimental Physiology, EarlyView.Abstract High‐intensity endurance exercise induces myocardial remodelling as an adaptive response to sustained volume overload, but excessive cumulative training might also favour deleterious cardiac remodelling, including atrial fibrosis. Whether acute marathon running engages circulating fibrosis‐related biomarkers and whether these biomarkers track ...
Felipe Contreras‐Briceño +6 more
wiley +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Mitochondria are highly dynamic organelles that continuously remodel their architecture through coordinated cycles of fusion and fission. This review examines the four key GTPases that orchestrate mitochondrial dynamics in mammals: MFN1, MFN2, OPA1, and DRP1.
Rémi Chaney +4 more
wiley +1 more source
The role of extracellular vesicles in cell–cell crosstalk in cardiotoxicity
The Journal of Physiology, EarlyView.Abstract figure legend Administration of a pharmacological agent can result in off‐target cardiotoxicity which can be driven by cell–cell crosstalk between healthy and dysfunctional cardiac cells. Extracellular vesicles (EVs) are lipid bilayer structures that can move biological cargo between cells, facilitating cell–cell crosstalk.
Gabriella Bachynskyj‐Bilas +5 more
wiley +1 more source
Caenorhabditis elegans as an in vivo model system for human inherited primary arrhythmia syndromes
The Journal of Physiology, EarlyView.Abstract figure legend Most genes involved in inherited primary arrhythmia syndromes (IPAS) are conserved in Caenorhabditis elegans, where genetic manipulation enables functional characterization of variants, identification of regulatory proteins, and in vivo drug testing.
Antoine Delinière +6 more
wiley +1 more source
Translating cardiovascular ion channel and Ca2+ signalling mechanisms into therapeutic insights
The Journal of Physiology, EarlyView.Abstract figure legend This white paper integrates mechanistic discoveries across ion channel biology, Ca2+ signalling and multiscale cardiovascular physiology to highlight new opportunities for accelerating research and guiding next‐generation therapies. Printed with permission from ®Anita Impagliazzo Medical Illustration. [Correction added on 2 March
Silvia Marchianò +18 more
wiley +1 more source
Deep Learning‐Based Dynamic Segmentation of the Left Atrium in 4D Flow MRI
Magnetic Resonance in Medicine, Volume 96, Issue 5, Page 2505-2515, November 2026.ABSTRACT Purpose To design a deep learning pipeline for automated, time‐resolved segmentation of the left atrium (LA) from 4D flow MRI data. Methods We studied 100 individuals including 65 patients with atrial fibrillation (AF) and 35 healthy subjects (HS) resulting in 2530 4D flow MRI time‐volumes acquired in different centers and scanners.
Jonas Leite +16 more
wiley +1 more source
“Two‐For‐One”: 4D Cardiac and Pulmonary MR Imaging From a Single Acquisition Using bSTAR
Magnetic Resonance in Medicine, Volume 96, Issue 5, Page 2213-2227, November 2026.ABSTRACT Purpose To generate 4D (3D+time) images of both the heart and lungs using a single volumetric radial free‐breathing bSSFP dual echo acquisition (bSTAR) with two image reconstructions within a single pipeline deployed inline at 0.55 and 1.5 T.
Pierre Daudé +9 more
wiley +1 more source
Animal Genetics, Volume 57, Issue 5, October 2026.ABSTRACT Previous studies suggest that genetic risk factors for dilated cardiomyopathy (DCM) in Dobermann dogs may differ between populations, complicating the use of genetic tests across subpopulations. Variants in pyruvate dehydrogenase kinase 4 (PDK4) and titin (TTN) have been associated with DCM in North American Dobermanns, whereas two loci on ...
Alma H. Hulsman +15 more
wiley +1 more source