Results 181 to 190 of about 69,694 (262)

10‐Gingerol Alleviates Arsenic Trioxide‐Induced Cardiotoxicity: Mechanisms Involving the PI3K/AKT Pathway Revealed by Network Pharmacology and Experimental Validation

Food Science &Nutrition, Volume 14, Issue 8, August 2026.
Network pharmacology combined with in vivo and in vitro experiments identified PI3K/AKT signaling as a candidate pathway associated with the protective effects of 10‐Gingerol (10Gin) against arsenic trioxide (ATO)‐induced cardiotoxicity. 10Gin improved myocardial histopathology and cardiac systolic function in ATO‐treated mice, while attenuating ...
Bin Zheng, Hui Yin, Jiabao Chen, Xiaodong Xin, Lan Yan, Chunhua Li, Hefei Wang, Hua Zhou   +7 more
wiley   +1 more source

Biomimetic astragaloside-IV-loaded mesoporous silica nanoparticles for treatment of dilated cardiomyopathy. [PDF]

Front Pharmacol
Wang C, Lv L, Long T, Xie T, Qi J, Pan H, Fang Y, Sun Y.   +7 more
europepmc   +1 more source

The Therapeutic Potential of Stem Cell Therapy for Doxorubicin‐Induced Cardiotoxicity: A Narrative Review

Health Science Reports, Volume 9, Issue 8, August 2026.
ABSTRACT Background and Aims Doxorubicin (DOX) is a potent anthracycline chemotherapeutic agent whose clinical utility is significantly constrained by severe side effects, most notably DOX‐induced cardiotoxicity (DIC). Pathophysiological mechanisms of DIC include oxidative stress, mitochondrial dysfunction, programmed cell death, and inflammation ...
Ali Mirzaei, Pouria Rezaei, Reza Golchin Vafa, Saleheh Jahani, Reza Arefnezhad, Hossein Fatemian, Mohammad Hossein Nikoo, Amirhossein Sahebkar, Fatemeh Rezaei‐Tazangi   +8 more
wiley   +1 more source

Atorvastatin Reduces Alcohol‐Related Cardiac and Liver Tissue Damage, Oxidative Stress, Inflammation, Apoptosis, and Thiol‐Disulfide Imbalance in Rats

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
Atorvastatin (40 mg/kg) inhibited fibrosis, hypertrophy, apoptosis, inflammation, and oxidative stress caused by alcohol consumption. It may contribute to the regulation of mitochondrial function and thiol/disulfide balance by limiting alcohol‐related heart and liver damage.
Cumaali Demirtas, Şahhan Kılıç, Mert Babaoğlu, Süha Asal, Elif Gökçe Tenekeci, Hakan Beyaztaş, Eray Metin Guler, Salime Pelin Erguven, Kubra Sevgin   +8 more
wiley   +1 more source

Evaluation of Women With Peripartum or Dilated Cardiomyopathy and Their First-Degree Relatives: The DCM Precision Medicine Study. [PDF]

Circ Genom Precis Med
Kransdorf EP, Jain R, Mead JO, Haas G, Hofmeyer M, Ewald GA, Diamond J, Owens A, Lowes B, Stoller D, Tang WHW, Drazner MH, Martin CM, Shah P, Tallaj J, Katz S, Jimenez J, Shore S, Smart F, Wang J, Gottlieb SS, Judge DP, Huggins GS, Cowan J, Parker P, Cao J, Hurst NS, Jordan E, Ni H, Kinnamon DD, Hershberger RE.   +30 more
europepmc   +1 more source

Midterm Efficacy of SubcutAneous Implantable CardioVErter‐Defibrillator in ≤ 18 Year‐Old CHILDREN (SAVE CHILDREN‐II Registry)

Journal of Arrhythmia, Volume 42, Issue 4, August 2026.
S‐ICD therapy demonstrated favorable mid‐term safety and efficacy in pediatric patients, with durable sensing performance and a low incidence of device‐related infection. ABSTRACT Background The subcutaneous implantable cardioverter‐defibrillator (S‐ICD) avoids transvenous leads and is a promising option for sudden cardiac death (SCD) prevention in ...
Hitoshi Mori, Taisuke Nabeshima, Kota Nagaoka, Hideo Fukunaga, Hidemori Hayashi, Osamu Inaba, Yuhei Isonaga, So Asano, Junichi Nitta, Shigeo Watanabe, Sou Otsuki, Hiroshi Suzuki, Hidehira Fukaya, Jun Kishihara, Toshiyuki Chisaka, Takashi Higaki, Ayako Okada, Hideki Kobayashi, Takayuki Sekihara, Takafumi Oka, Seiichi Sato, Keisuke Yoshino, Hidekazu Kondo, Naohiko Takahashi, Ken Kato, Masaru Miura, Jun Maeda, Shuntaro Tamura, Kentaro Ikeda, Hiroko Goto, Takashi Murakami, Tsutomu Wada, Motoki Takamuro, Tsugutoshi Suzuki, Yuji Ishida, Shingo Sasaki, Takuro Nishimura, Masateru Takigawa, Tomomi Matsuura, Tomohiko Imamura, Satoshi Shizuta, Masato Fukunaga, Maiko Kuroda, Rintaro Hojo, Seiji Fukamizu, Hirohiko Suzuki, Yukihiko Yoshida, Itsuro Morishima, Kenji Kuraishi, Eiki Nishihara, Yoshihisa Naruse, Tomoyuki Sato, Yoshiyasu Aizawa, Kimitaka Nishizaki, Kentaro Nakamura, Norihito Nuruki, Masao Yoshinaga, Yukitoshi Ikeya, Yasuo Okumura, Shota Muraji, Yusuke Kondo, Makoto Nakano, Machiko Kito, Yasuya Inden, Satoshi Higuchi, Takahiko Kinjo, Kazuhisa Matsumoto, Masataka Narita, Wataru Sasaki, Tsukasa Naganuma, Daisuke Kawano, Naomichi Tanaka, Kei Matsumoto, Takuro Kojima, Yoshifumi Ikeda, Ritsushi Kato, Naokata Sumitomo   +76 more
wiley   +1 more source

The natural history of autosomal recessive atrial dilated cardiomyopathy associated with mutation of natriuretic peptide precursor A. [PDF]

Europace
Marini M, Iseppi M, Quintarelli S, Tedoldi F, Ravelli F, Bonmassari R, Arbustini E.   +6 more
europepmc   +1 more source

Artificial Intelligence Techniques in Cardiac Neuromodulation: Mechanisms, Applications, and Pathways to Clinical Translation

Journal of Arrhythmia, Volume 42, Issue 4, August 2026.
Artificial intelligence could improve patient selection, stimulation control, and response monitoring in cardiac neuromodulation, yet direct clinical evidence remains scarce. We map available techniques onto these three challenges and argue that safe, adaptive closed‐loop control and established therapy efficacy are prerequisites for translation ...
Kshitiz Pandey, Pratik Pandey, Sushmita Khanal, Ashish Panday   +3 more
wiley   +1 more source

SIRT Family: Biological Functions and Therapeutic Targets

MedComm, Volume 7, Issue 8, August 2026.
SIRT1–SIRT7 networks from transgenic mice to human‑relevant therapeutic targets. SIRT1–SIRT7 form an isoform‑, organ‑, and disease‑specific regulatory network. Transgenic Sirt1–7 mouse models define central regulatory SIRTs (SIRT1, SIRT3, SIRT6), context‑dependent modifiers (SIRT2, SIRT4, SIRT5, SIRT7), and their key mechanisms and target organs. These
Jia‐Yi Wang, Feng‐Li Jiang, Fang‐Yuan Zhang, Dong‐Hui Huang, Xiao‐Ying Li, Song Gao, Hua You, Qi‐Jun Wu, Huan‐Huan Chen, Ting‐Ting Gong   +9 more
wiley   +1 more source