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Artificial intelligence-enabled "inherited noninvasive intracellular recording" for prolonged monitoring of cardiac action potentials. [PDF]
Liu S +17 more
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Asymmetric syntheses of (+)-diltiazem hydrochloride
Journal of the Chemical Society, Chemical Communications, 1990Efficient enantioselective syntheses of the important cardiac drug (+)-cis-(2S,3S)-diltiazem from (E)-methyl 4-methoxyphenylpropenoate via either the (2R,3S)- or (2S,3R)-enantiomers of threo-methyl 3-(4-methoxyphenyl)-2,3-dihydroxypropanoate are described.
Keith G. Watson +6 more
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Controlled release of diltiazem hydrochloride
Polymer International, 1995AbstractA new type of complex reservoir–matrix system for the controlled delivery of diltiazen hydrochloride was developed. This capsule‐type device was designed for oral administration to humans and/or animals. It contained (i) an appropriate amount of the drug in a compartment; (ii) a swelling‐controlled membrane which was prepared by mixing ...
Ping Xu +4 more
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British journal of hospital medicine, 1995
Since their introduction in 1963, calcium-channel blockers, with their effectiveness and lack of side effects, have become widely used. Diltiazem hydrochloride, a benzothiazine, has its major role in the treatment of angina and is also used as an antihypertensive and antiarrhythmic.
D, Harrington, D J, Coltart
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Since their introduction in 1963, calcium-channel blockers, with their effectiveness and lack of side effects, have become widely used. Diltiazem hydrochloride, a benzothiazine, has its major role in the treatment of angina and is also used as an antihypertensive and antiarrhythmic.
D, Harrington, D J, Coltart
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STABILITY OF DILTIAZEM HYDROCHLORIDE IN AQUEOUS SUGAR SOLUTIONS
Journal of Clinical Pharmacy and Therapeutics, 1988The accelerated stability of diltiazem in aqueous sugar solutions, with or without sodium dihydrogen phosphate, was investigated using a high-pressure liquid chromatographic method. The degradation of diltiazem in all sugar solutions followed pseudo first-order kinetics.
M S, Suleiman +2 more
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The Use of Diltiazem Hydrochloride in Cardiovascular Disorders
Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 1982Diltiazem, a calcium channel blocking agent, has potent cardiovascular effects that are directly related to its influence on vascular smooth muscle, ventricular myocardium, and specialized conducting tissue. It causes coronary and peripheral vasodilation, has a negative chronotropic and dromotropic effect, and little to no negative inotropic effect in ...
B J, McAuley, J S, Schroeder
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Electrophysiologic effects of diltiazem hydrochloride on supraventricular tachycardia
The American Journal of Cardiology, 1982The effects of intravenous diltiazem hydrochloride (0.25 mg/kg body weight) were studied in eight patients with nine episodes of supraventricular tachycardia. Five episodes of tachycardia were due to atrioventricular (A-V) nodal reentry (group A), two were due to retrograde utilization of a concealed A-V accessory pathway (group B) and two were ...
J J, Rozanski, L, Zaman, A, Castellanos
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Hydrocolloid Carriers with Filler Inclusionfor Diltiazem Hydrochloride Release
Journal of Pharmaceutical Sciences, 2007Hydrocolloid beads based on agarose, alginate (both 3%, w/w), or gellan (2%, w/w) were produced to study their potential as drug carriers. The beads included various fillers: talc, kaolin, calcium carbonate, potato, or corn starch (10%, w/w). After gelation, the carriers were subjected to either freeze- or vacuum-drying.
A, Gal, A, Nussinovitch
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