Results 1 to 10 of about 1,204 (97)

Sustainable Ethanol-Based Reversed-Phase Liquid Chromatography for Determination of Diltiazem pKa and Quantification with Integrated Green and White Analytical Metrics. [PDF]

ChemistryOpen
A sustainable reversed‐phase liquid chromatography method is developed for diltiazem analysis and pKadetermination. The study integrates green and white analytical chemistry frameworks to evaluate environmental impact and practicality. The Environmental, Performance, and Practicality Index is utilized as a comprehensive, holistic tool for the ...
Üstün Z, Konçe İ, Çubuk Demiralay E.   +2 more
europepmc   +2 more sources

A Combined Experimental and Predictive Modeling Study of Diltiazem Release From Natural Polymer Microcapsules in Different Media. [PDF]

CPT Pharmacometrics Syst Pharmacol
A mechanistic sublingual absorption model was developed by integrating in vitro release kinetics of diltiazem‐loaded microcapsules with a SimBiology‐based two‐compartment model, enabling simulation of in vivo performance across physiologically relevant pH variability scenarios.
Üstün Z, Kara Ü.
europepmc   +2 more sources

Antimicrobial activities of Diltiazem Hydrochloride: drug repurposing approach [PDF]

PeerJ
Background The growing concern of antibiotic-resistant microbial strains worldwide has prompted the need for alternative methods to combat microbial resistance.
Omar K. Alduaij, Rageh K. Hussein, Sharif Abu Alrub, Sabry A. H. Zidan   +3 more
doaj   +3 more sources

Antiviral Activity of Diltiazem HCl Against Pseudorabies Virus Infection In Vitro [PDF]

Veterinary Sciences
Pseudorabies virus (PRV) is a highly pathogenic agent that adversely impacts swine populations, leading to considerable economic losses within the Chinese pig industry.
Mengting Zuo, Decai Xiang, Zhen-Xing Zhang, Xi Yang, Yuqing Duan, Juan Li, Bangquan Zeng, Lu Dong, Guoquan Wu, Yi Zhou, Lei Tan, Bofang Duan   +11 more
doaj   +2 more sources

Antiplasmodial Activity and Pharmacokinetic Profiling of Cryptolepine and 2,7-Dibromocryptolepine With a View to Informing the Design of Novel Antimalarial Cryptolepine Analogues. [PDF]

Drug Dev Res
ABSTRACT The roots of the climbing shrub Cryptolepis sanguinolenta are traditionally used in West Africa for the treatment of malaria. The principal constituent, cryptolepine (1), has been shown to have antimalarial activity but there are concerns regarding its toxicity on account of its DNA‐intercalating property.
Chenu E, Duffy J, Forkuo AD, Gbedema SY, Abdelall S, Wahajuddin M, Jones HS, Wright CW.   +7 more
europepmc   +2 more sources

Anogenital Contact Dermatitis in Spain: A REIDAC Study of Patients Undergoing Patch Testing in 2019-2024. [PDF]

Contact Dermatitis
Allergic contact dermatitis is very common in patients with anogenital lesions referred for patch testing in Spain. Key allergens include fragrances, preservatives and topical treatments like anaesthetics and steroids. Emerging sensitisers including benzisothiazolinone and sodium metabisulphite are also relevant.
Grau-Pérez M, Mercader-García P, Giménez-Arnau AM, Sanz-Sánchez T, Ninet VZ, Guijarro SC, Miquel FJM, Salvador JFS, González-Pérez R, González IR, Baldrich ES, Carrascosa JM, de Frutos FJO, Serna MR, Ortega MEG, Suárez CP, Triviño FJN, Chicharro P, Andreu M, Gilo AS, Pereyra Rodríguez JJ, Nieto MAP, Melé-Ninot G, Guillén PS, de la Fuente EG, Elosua-González M, Munera-Campos M, Romero FT, Descalzo MÁ, Borrego L.   +29 more
europepmc   +2 more sources

Neuron-non-neuron electrical coupling networks are involved in chronic stress-induced electrophysiological changes in lateral habenular neurons. [PDF]

J Physiol
Abstract figure legend We investigated electrophysiological changes in lateral habenula (LHb) neurons induced by chronic social defeat stress in mice. LHb neurons exhibited short (<400 ms) rebound depolarizing potentials (short‐RDPs) or long‐RDPs (order of seconds) (long‐RDPs) after the offset of hyperpolarization. The incidence of long‐RDP neurons was
Yamaoka K, Nozaki K, Zhu M, Terai H, Kobayashi K, Ito H, Matsumata M, Takemoto H, Ikeda S, Sotomaru Y, Mori T, Aizawa H, Hashimoto K.   +12 more
europepmc   +2 more sources

A Facile Protocol for C(sp²)-C(sp³) Bond Formation Reactions Toward Functionalized E3 Ligase Ligands. [PDF]

ChemMedChem
A robust C(sp2)–C(sp3) decarboxylative coupling strategy enables access to new CRBN ligands and degraders with improved physicochemical properties. This synthetic approach is expanding the chemical space beyond C(sp2)–N linkages, fine‐tuning proteolysis‐targeting chimera activities and unlocking previously inaccessible degrader chemotypes.
Maksutova A, Geiger TM, Cianni L, Pieńkowska DE, Gerhartz J, Read L, Bricelj A, Herrmann A, Nelles ML, Ng YLD, Hartmann MD, Krönke J, Sosič I, Nowak RP, Gütschow M, Steinebach C.   +15 more
europepmc   +2 more sources

Microencapsulation by Spray Coagulation of Diltiazem HCl in Calcium Alginate-Coated Chitosan [PDF]

AAPS PharmSciTech, 2008
Mehrdad Yazdani-Pedram, Cristian Tapia
exaly   +2 more sources

Optimization of Hydroxy Propyl Methyl Cellulose and Carbomer In Diltiazem Hydrochloride Mucoadhesive Buccal Film

Indonesian Journal of Pharmacy, 2021
Diltiazem hydrochloride (HCl) is a category of calcium channel blocker used as an antihypertensive agent. Diltiazem HCl is a low bioavailable drug due to high first-pass metabolism and a short half-life (3-5 hours); hence mucoadhesive buccal film was ...
Lina Winarti, Bagus Tri Laksono, Lusia Oktora Ruma Kumala Sari   +2 more
doaj   +1 more source