Development and evaluation of microporous osmotic tablets of diltiazem hydrochloride
Journal of Advanced Pharmaceutical Technology & Research, 2012 Microporous osmotic tablet of diltiazem hydrochloride was developed for colon targeting. These prepared microporous osmotic pump tablet did not require laser drilling to deliver the drug to the specific site of action.
Afifa Bathool +5 more
doaj +1 more source
British Journal of Pharmacology, Volume 183, Issue 16, Page 4646-4662, August 2026.Abstract Background and Purpose Ventricular fibrillation (VF) in coronary heart disease accounts for up to 70% of sudden cardiac death. We examined whether diltiazem N‐oxide (DNO) has ischaemia‐selective antiarrhythmic activity. Experimental Approach Randomised and blinded experiments were performed in rat isolated hearts and in anaesthetised rats to ...
Louise M. Hesketh +5 more
wiley +1 more source
FORMULATION AND EVALUATION OF FLOATING BEADS OF DILTIAZEM HCL [PDF]
, 2016 Objective: Diltiazem, a benzothiazepine calcium channel blocker, is used alone or with an angiotensin-converting enzyme inhibitor, to treat hypertension, chronic stable angina pectoris, and Prinzmetal\u27s variant angina.
AGARWAL, SHIVENDRA +3 more
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EVALUASI IN VITRO-IN VIVO FILM TRANDERMAL DILTIAZEM HCL DENGAN PENINGKAT PENETRASI PEG 400 SEBAGAI ANTIHIPERTENSI [PDF]
, 2019 Diltiazem HCL is an antihypertensive that low oral bioavailability of 40%, so developed to transdermal preparations. A matrix type of transdermal patch of diltiazem HCl was prepared using polyvinyl alcohol and ethyl cellulose with PEG 400 as penetration ...
Fithria, Risha Fillah +7 more
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Optimasi Hydroxypropyl Methylcellulose dan Chitosan pada Tablet Floating-Mucoadhesive Diltiazem Hidroklorida Menggunakan Desain Faktorial [PDF]
, 2020 Diltiazem HCl is one of the drugs used for hypertension treatment. It requires frequent dosing, which is why diltiazem HCl needs to be formulated into preparations using a controlled release drug delivery system.
Triastutik, Irsalina +2 more
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Vegetable Oil‐Based Materials for Drug Delivery Systems and Wound Dressings
Macromolecular Bioscience, Volume 26, Issue 3, March 2026.Renewable resources like vegetable oils are increasingly explored for biomaterial production in biomedical applications. Their monoglycerides and triglycerides inherently possess functions or can be chemically modified to introduce functional groups suitable for polymerization, yielding biomaterials with desirable properties such as flexibility ...
Lucas M. Favre +2 more
wiley +1 more source
The influence of fillers on theophylline release from clay matrices [PDF]
, 2015 : The objectives of this study were to investigate the suitability of magnesium aluminium silicate (MAS) (Veegum®) to control drug release of a model drug, theophylline, from tablet matrices.
Asare-Addo, Kofi +2 more
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Selectivity in the Separation of Diltiazem and its Related Substances by HPLC with Core-shell Type Reversed-phase Columns Having a Planar Moiety and Development of a Fast Analysis of Diltiazem Formulations [PDF]
, 2020 Recently UHPLC, where smaller particle (2～3 μm) packing materials are employed, is progressing rapidly. Higher performance (higher theoretical plate number, lower theoretical plate height) and fast analysis can be obtained by the UHPLC, compared with the
イナガキ, マサノリ +24 more
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FORMULASI TABLET LEPAS LAMBAT DILTIAZEM HIDROKLORIDA DENGAN SISTEM MENGAPUNG [PDF]
, 2015 Diltiazem diberikan secara oral untuk pengobatan angina pektoris dan hipertensi. Diltiazem HCl memiliki waktu paruh 3-4 jam dengan bioavaibilitas 40%.
Ijel, Ahmadi
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SEPARATION SCIENCE PLUS, Volume 8, Issue 10, October 2025.ABSTRACT A quality by design (QbD)‐aided stability‐indicating method was developed for the simultaneous quantification of alprazolam and its four impurities using HPLC. The method was systematically optimized, followed by the establishment of a “method operable design region (MODR).” Critical parameters and ICH (Q14) emphasize the adherence to a “low ...
Mahesh Napa +4 more
wiley +1 more source