Results 31 to 40 of about 1,171 (97)

The effect of pH and Polymer type on Release of Diltiazem HCl from hydrophilic matrices

open access: yesJournal of Mazandaran University of Medical Sciences, 2007
Background and Purpose: Oral administrations have been used for many years as a main method comparing to other methods. Sustained release techniques have been a great interest recently.
J. Akbari, Ph.D.   +3 more
doaj  

Thinking Three‐Dimensionally: A Self‐ and Externally‐Controlled Approach to Screening for Drug–Drug–Drug Interactions Among High‐Risk Populations

open access: yesClinical Pharmacology &Therapeutics, Volume 116, Issue 2, Page 448-459, August 2024.
The global rise in polypharmacy has increased both the necessity and complexity of drug–drug interaction (DDI) assessments, given the growing potential for interactions involving more than two drugs. Leveraging large‐scale healthcare claims data, we piloted a semi‐automated, high‐throughput case‐crossover‐based approach for drug–drug–drug interaction ...
Emily K. Acton   +7 more
wiley   +1 more source

The Tissue‐Specific Eco‐Exposome: Differential Pharmaceutical Bioaccumulation and Disposition in Fish among Trophic Positions

open access: yesEnvironmental Toxicology and Chemistry, Volume 43, Issue 8, Page 1894-1902, August 2024.
Abstract Though bioaccumulation of pharmaceuticals by aquatic organisms continues to receive scientific attention, the internal disposition of these contaminants among different tissue compartments of fish species has been infrequently investigated, particularly among fish at different trophic positions. We tested a human to fish biological read‐across
Jaylen L. Sims   +8 more
wiley   +1 more source

Pharmacokinetics and Pharmacodynamics of Etripamil, an Intranasally Administered, Fast‐Acting, Nondihydropyridine Calcium Channel Blocker

open access: yesClinical Pharmacology in Drug Development, Volume 13, Issue 4, Page 367-379, April 2024.
Abstract Etripamil, a fast‐acting nondihydropyridine L‐type calcium channel blocker, is under investigation for potential self‐administration for the acute treatment of supraventricular tachyarrhythmias in a medically unsupervised setting. We report detailed pharmacokinetics and pharmacodynamics of intranasally administered etripamil in healthy adults ...
James E. Ip   +5 more
wiley   +1 more source

TRPV4 promotes HBV replication and capsid assembly via methylation modification of H3K4 and HBc ubiquitin

open access: yesJournal of Medical Virology, Volume 96, Issue 4, April 2024.
Abstract Hepatitis B virus (HBV) infection poses a significant burden on global public health. Unfortunately, current treatments cannot fully alleviate this burden as they have limited effect on the transcriptional activity of the tenacious covalently closed circular DNA (cccDNA) responsible for viral persistence.
Yu Zhang   +9 more
wiley   +1 more source

An investigation into the stabilization of diltiazem HCl release from matrices made from aged polyox powders. [PDF]

open access: yesAAPS PharmSciTech, 2013
Shojaee S   +4 more
europepmc   +1 more source

Home - About - Disclaimer - Privacy