Sustainable Ethanol-Based Reversed-Phase Liquid Chromatography for Determination of Diltiazem pKa and Quantification with Integrated Green and White Analytical Metrics. [PDF]
ChemistryOpenA sustainable reversed‐phase liquid chromatography method is developed for diltiazem analysis and pKadetermination. The study integrates green and white analytical chemistry frameworks to evaluate environmental impact and practicality. The Environmental, Performance, and Practicality Index is utilized as a comprehensive, holistic tool for the ...
Üstün Z +2 more
europepmc +2 more sources
The effect of pH and Polymer type on Release of Diltiazem HCl from hydrophilic matrices
Journal of Mazandaran University of Medical Sciences, 2007 Background and Purpose: Oral administrations have been used for many years as a main method comparing to other methods. Sustained release techniques have been a great interest recently.
J. Akbari, Ph.D. +3 more
doaj +1 more source
Antiplasmodial Activity and Pharmacokinetic Profiling of Cryptolepine and 2,7-Dibromocryptolepine With a View to Informing the Design of Novel Antimalarial Cryptolepine Analogues. [PDF]
Drug Dev ResABSTRACT The roots of the climbing shrub Cryptolepis sanguinolenta are traditionally used in West Africa for the treatment of malaria. The principal constituent, cryptolepine (1), has been shown to have antimalarial activity but there are concerns regarding its toxicity on account of its DNA‐intercalating property.
Chenu E +7 more
europepmc +2 more sources
Neuron-non-neuron electrical coupling networks are involved in chronic stress-induced electrophysiological changes in lateral habenular neurons. [PDF]
J PhysiolAbstract figure legend We investigated electrophysiological changes in lateral habenula (LHb) neurons induced by chronic social defeat stress in mice. LHb neurons exhibited short (<400 ms) rebound depolarizing potentials (short‐RDPs) or long‐RDPs (order of seconds) (long‐RDPs) after the offset of hyperpolarization. The incidence of long‐RDP neurons was
Yamaoka K +12 more
europepmc +2 more sources
Anogenital Contact Dermatitis in Spain: A REIDAC Study of Patients Undergoing Patch Testing in 2019-2024. [PDF]
Contact DermatitisAllergic contact dermatitis is very common in patients with anogenital lesions referred for patch testing in Spain. Key allergens include fragrances, preservatives and topical treatments like anaesthetics and steroids. Emerging sensitisers including benzisothiazolinone and sodium metabisulphite are also relevant.
Grau-Pérez M +29 more
europepmc +2 more sources
Indonesian Journal of Pharmacy, 2021 Diltiazem hydrochloride (HCl) is a category of calcium channel blocker used as an antihypertensive agent. Diltiazem HCl is a low bioavailable drug due to high first-pass metabolism and a short half-life (3-5 hours); hence mucoadhesive buccal film was ...
Lina Winarti +2 more
doaj +1 more source
SIMULTANEOUS HPLC-UV QUANTIFICATION OF DILTIAZEM AND N-DEMETHYLDILTIAZEM IN HUMAN PLASMA [PDF]
Bulletin of Pharmaceutical Sciences. Assiut University, 2006 A simple and sensitive reversed phase high-performance liquidchromatographic method was developed for simultaneousquantification of diltiazem HCl and its major metabolite Ndemethyldiltiazemin human plasma.
S. Raza +3 more
doaj +1 more source
Journal of Pharmaceutical Analysis, 2020 An understanding of the thermodynamics of the complexation process utilized in sustaining drug release in clay matrices is of great importance. Several characterisation techniques as well as isothermal calorimetry were utilized in investigating the ...
Ana-Maria Totea +7 more
doaj +1 more source
Formulation and In-Vitro Evaluation of Mucoadhesive Diltiazem Hydrochloride Buccal Tablets
Al-Mustansiriyah Journal of Pharmaceutical Sciences, 2011 Mucoadhesive tablets for buccal administration of diltiazem hydrochloride were prepared as an alternative to available diltiazem HCl dosage forms. Two types of tablets were developed each containing two mucoadhesive components (hydroxypropylmethyl ...
Lubna A. Sabri
doaj +1 more source