Results 11 to 20 of about 4,480 (170)

DESIGN AND EVALUATION OF BILAYER FLOATING TABLETS OF DILTIAZEM HCL [PDF]

, 2017
The present investigation concerns design and evaluation of bilayer floating tablets of Diltiazem HCl Diltiazem HCl is Class I drug, though its reported bioavailability is only 40 %. It is having very short half life of 3 to 4 hrs.
Shaikh Siraj Nawaj*, Md. ZuberPatel,,G. J. Khan, Patel M Siddik,ZakirShaikh
core   +2 more sources

Effect of solvent on retarding the release of diltiazem HCl from Polyox-based liquisolid tablets

Journal of Pharmacy and Pharmacology, 2016
Abstract Objectives The aim of this work was to investigate the use of liquisolid technique to sustain the release of a model highly soluble drug, diltiazem HCl, from liquisolid matrices containing Polyox, a recently proposed matrix-forming hydrophilic polymer as an alternative to hypromellose.
Waseem Kaialy, Kofi Asare-Addo, Ali Nokhodchi   +2 more
exaly   +5 more sources

Sustainable Ethanol-Based Reversed-Phase Liquid Chromatography for Determination of Diltiazem pKa and Quantification with Integrated Green and White Analytical Metrics. [PDF]

ChemistryOpen
A sustainable reversed‐phase liquid chromatography method is developed for diltiazem analysis and pKadetermination. The study integrates green and white analytical chemistry frameworks to evaluate environmental impact and practicality. The Environmental, Performance, and Practicality Index is utilized as a comprehensive, holistic tool for the ...
Üstün Z, Konçe İ, Çubuk Demiralay E.   +2 more
europepmc   +2 more sources

The effect of pH and Polymer type on Release of Diltiazem HCl from hydrophilic matrices

Journal of Mazandaran University of Medical Sciences, 2007
Background and Purpose: Oral administrations have been used for many years as a main method comparing to other methods. Sustained release techniques have been a great interest recently.
J. Akbari, Ph.D.,  R. Enayati-fard, Ph.D, M. Saeedi, Ph.D., A. Aghpour, Pharm.D   +3 more
doaj   +1 more source

Antiplasmodial Activity and Pharmacokinetic Profiling of Cryptolepine and 2,7-Dibromocryptolepine With a View to Informing the Design of Novel Antimalarial Cryptolepine Analogues. [PDF]

Drug Dev Res
ABSTRACT The roots of the climbing shrub Cryptolepis sanguinolenta are traditionally used in West Africa for the treatment of malaria. The principal constituent, cryptolepine (1), has been shown to have antimalarial activity but there are concerns regarding its toxicity on account of its DNA‐intercalating property.
Chenu E, Duffy J, Forkuo AD, Gbedema SY, Abdelall S, Wahajuddin M, Jones HS, Wright CW.   +7 more
europepmc   +2 more sources

Anogenital Contact Dermatitis in Spain: A REIDAC Study of Patients Undergoing Patch Testing in 2019-2024. [PDF]

Contact Dermatitis
Allergic contact dermatitis is very common in patients with anogenital lesions referred for patch testing in Spain. Key allergens include fragrances, preservatives and topical treatments like anaesthetics and steroids. Emerging sensitisers including benzisothiazolinone and sodium metabisulphite are also relevant.
Grau-Pérez M, Mercader-García P, Giménez-Arnau AM, Sanz-Sánchez T, Ninet VZ, Guijarro SC, Miquel FJM, Salvador JFS, González-Pérez R, González IR, Baldrich ES, Carrascosa JM, de Frutos FJO, Serna MR, Ortega MEG, Suárez CP, Triviño FJN, Chicharro P, Andreu M, Gilo AS, Pereyra Rodríguez JJ, Nieto MAP, Melé-Ninot G, Guillén PS, de la Fuente EG, Elosua-González M, Munera-Campos M, Romero FT, Descalzo MÁ, Borrego L.   +29 more
europepmc   +2 more sources

Neuron-non-neuron electrical coupling networks are involved in chronic stress-induced electrophysiological changes in lateral habenular neurons. [PDF]

J Physiol
Abstract figure legend We investigated electrophysiological changes in lateral habenula (LHb) neurons induced by chronic social defeat stress in mice. LHb neurons exhibited short (<400 ms) rebound depolarizing potentials (short‐RDPs) or long‐RDPs (order of seconds) (long‐RDPs) after the offset of hyperpolarization. The incidence of long‐RDP neurons was
Yamaoka K, Nozaki K, Zhu M, Terai H, Kobayashi K, Ito H, Matsumata M, Takemoto H, Ikeda S, Sotomaru Y, Mori T, Aizawa H, Hashimoto K.   +12 more
europepmc   +2 more sources

Aptamer-based cocaine assay using a nanohybrid composed of ZnS/Ag2Se quantum dots, graphene oxide and gold nanoparticles as a fluorescent probe [PDF]

, 2020
Authors report on a new fluoro-graphene-plasmonic nanohybrid aptamer-based fluorescent nanoprobe for cocaine. To construct the nanoprobe, newly synthesized glutathione-capped ZnS/Ag 2Se quantum dots (QDs) were first conjugated to graphene oxide (GO) to ...
Abdolvand, Amin, Adegoke, Oluwasesan, Nic Daeid, Niamh, Pereira-Barros, Magda A., Zolotovskaya, Svetlana   +4 more
core   +2 more sources

Optimasi Hidroksipropil Metilselulosa dan Polivinil Pirolidon dalam Sediaan Mucoadhesive Buccal Film Diltiazem Hidroklorida [PDF]

, 2021
Diltiazem HCl is a class of benzodiazepine calcium channel blockers used to treat angina pectoris, arrhythmias, and hypertension. Diltiazem HCl improves first-pass metabolism, a short half time of 3-5 hours, and bioavailability of diltiazem for oral ...
Sari, Lusia Oktora Ruma Kumala, Sudianingsih, Septi, Wicaksono, Yudi   +2 more
core   +2 more sources

Thermodynamics of clay–drug complex dispersions: Isothermal titration calorimetry and high-performance liquid chromatography

Journal of Pharmaceutical Analysis, 2020
An understanding of the thermodynamics of the complexation process utilized in sustaining drug release in clay matrices is of great importance. Several characterisation techniques as well as isothermal calorimetry were utilized in investigating the ...
Ana-Maria Totea, Juan Sabin, Irina Dorin, Karl Hemming, Peter R. Laity, Barbara R. Conway, Laura Waters, Kofi Asare-Addo   +7 more
doaj   +1 more source