Results 11 to 20 of about 1,171 (97)

Sustainable Ethanol-Based Reversed-Phase Liquid Chromatography for Determination of Diltiazem pKa and Quantification with Integrated Green and White Analytical Metrics. [PDF]

ChemistryOpen
A sustainable reversed‐phase liquid chromatography method is developed for diltiazem analysis and pKadetermination. The study integrates green and white analytical chemistry frameworks to evaluate environmental impact and practicality. The Environmental, Performance, and Practicality Index is utilized as a comprehensive, holistic tool for the ...
Üstün Z, Konçe İ, Çubuk Demiralay E.   +2 more
europepmc   +2 more sources

Antiplasmodial Activity and Pharmacokinetic Profiling of Cryptolepine and 2,7-Dibromocryptolepine With a View to Informing the Design of Novel Antimalarial Cryptolepine Analogues. [PDF]

Drug Dev Res
ABSTRACT The roots of the climbing shrub Cryptolepis sanguinolenta are traditionally used in West Africa for the treatment of malaria. The principal constituent, cryptolepine (1), has been shown to have antimalarial activity but there are concerns regarding its toxicity on account of its DNA‐intercalating property.
Chenu E, Duffy J, Forkuo AD, Gbedema SY, Abdelall S, Wahajuddin M, Jones HS, Wright CW.   +7 more
europepmc   +2 more sources

Antiviral Activity of Diltiazem HCl Against Pseudorabies Virus Infection In Vitro [PDF]

Veterinary Sciences
Pseudorabies virus (PRV) is a highly pathogenic agent that adversely impacts swine populations, leading to considerable economic losses within the Chinese pig industry.
Mengting Zuo, Decai Xiang, Zhen-Xing Zhang, Xi Yang, Yuqing Duan, Juan Li, Bangquan Zeng, Lu Dong, Guoquan Wu, Yi Zhou, Lei Tan, Bofang Duan   +11 more
doaj   +2 more sources

Anogenital Contact Dermatitis in Spain: A REIDAC Study of Patients Undergoing Patch Testing in 2019-2024. [PDF]

Contact Dermatitis
Allergic contact dermatitis is very common in patients with anogenital lesions referred for patch testing in Spain. Key allergens include fragrances, preservatives and topical treatments like anaesthetics and steroids. Emerging sensitisers including benzisothiazolinone and sodium metabisulphite are also relevant.
Grau-Pérez M, Mercader-García P, Giménez-Arnau AM, Sanz-Sánchez T, Ninet VZ, Guijarro SC, Miquel FJM, Salvador JFS, González-Pérez R, González IR, Baldrich ES, Carrascosa JM, de Frutos FJO, Serna MR, Ortega MEG, Suárez CP, Triviño FJN, Chicharro P, Andreu M, Gilo AS, Pereyra Rodríguez JJ, Nieto MAP, Melé-Ninot G, Guillén PS, de la Fuente EG, Elosua-González M, Munera-Campos M, Romero FT, Descalzo MÁ, Borrego L.   +29 more
europepmc   +2 more sources

Neuron-non-neuron electrical coupling networks are involved in chronic stress-induced electrophysiological changes in lateral habenular neurons. [PDF]

J Physiol
Abstract figure legend We investigated electrophysiological changes in lateral habenula (LHb) neurons induced by chronic social defeat stress in mice. LHb neurons exhibited short (<400 ms) rebound depolarizing potentials (short‐RDPs) or long‐RDPs (order of seconds) (long‐RDPs) after the offset of hyperpolarization. The incidence of long‐RDP neurons was
Yamaoka K, Nozaki K, Zhu M, Terai H, Kobayashi K, Ito H, Matsumata M, Takemoto H, Ikeda S, Sotomaru Y, Mori T, Aizawa H, Hashimoto K.   +12 more
europepmc   +2 more sources

A Facile Protocol for C(sp²)-C(sp³) Bond Formation Reactions Toward Functionalized E3 Ligase Ligands. [PDF]

ChemMedChem
A robust C(sp2)–C(sp3) decarboxylative coupling strategy enables access to new CRBN ligands and degraders with improved physicochemical properties. This synthetic approach is expanding the chemical space beyond C(sp2)–N linkages, fine‐tuning proteolysis‐targeting chimera activities and unlocking previously inaccessible degrader chemotypes.
Maksutova A, Geiger TM, Cianni L, Pieńkowska DE, Gerhartz J, Read L, Bricelj A, Herrmann A, Nelles ML, Ng YLD, Hartmann MD, Krönke J, Sosič I, Nowak RP, Gütschow M, Steinebach C.   +15 more
europepmc   +2 more sources

Development and evaluation of microporous osmotic tablets of diltiazem hydrochloride

Journal of Advanced Pharmaceutical Technology & Research, 2012
Microporous osmotic tablet of diltiazem hydrochloride was developed for colon targeting. These prepared microporous osmotic pump tablet did not require laser drilling to deliver the drug to the specific site of action.
Afifa Bathool, D V Gowda, Mohammed S Khan, Ayaz Ahmed, S L Vasudha, K Rohitash   +5 more
doaj   +1 more source

A Combined Experimental and Predictive Modeling Study of Diltiazem Release From Natural Polymer Microcapsules in Different Media

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 7, July 2026.
A mechanistic sublingual absorption model was developed by integrating in vitro release kinetics of diltiazem‐loaded microcapsules with a SimBiology‐based two‐compartment model, enabling simulation of in vivo performance across physiologically relevant pH variability scenarios.
Zehra Üstün, Ümit Kara
wiley   +1 more source

Vegetable Oil‐Based Materials for Drug Delivery Systems and Wound Dressings

Macromolecular Bioscience, Volume 26, Issue 3, March 2026.
Renewable resources like vegetable oils are increasingly explored for biomaterial production in biomedical applications. Their monoglycerides and triglycerides inherently possess functions or can be chemically modified to introduce functional groups suitable for polymerization, yielding biomaterials with desirable properties such as flexibility ...
Lucas M. Favre, Nicolas Masurier, Anne Aubert‐Pouëssel   +2 more
wiley   +1 more source

Development and Validation of Quality by Design‐Based HPLC Method for Impurity Profiling of Alprazolam

SEPARATION SCIENCE PLUS, Volume 8, Issue 10, October 2025.
ABSTRACT A quality by design (QbD)‐aided stability‐indicating method was developed for the simultaneous quantification of alprazolam and its four impurities using HPLC. The method was systematically optimized, followed by the establishment of a “method operable design region (MODR).” Critical parameters and ICH (Q14) emphasize the adherence to a “low ...
Mahesh Napa, Venkata Ratnam K., Venkata Nadh Ratnakaram, Sunil Dhuri, Bondigalla Ramachandra   +4 more
wiley   +1 more source