Results 21 to 30 of about 1,171 (97)

Sex‐specific mechanisms of cerebral microvascular BKCa dysfunction in a mouse model of Alzheimer's disease

Alzheimer's &Dementia, Volume 21, Issue 2, February 2025.
Abstract INTRODUCTION Cerebrovascular dysfunction occurs in Alzheimer's disease (AD), impairing hemodynamic regulation. Large conductance Ca2+‐activated K+ channels (BKCa) regulate cerebrovascular reactivity and are impaired in AD. BKCa activity depends on intracellular Ca2+ (Ca2+ sparks) and nitro‐oxidative post‐translational modifications.
Josiane F. Silva, Felipe D. Polk, Paige E. Martin, Stephenie H. Thai, Andrea Savu, Matthew Gonzales, Allison M. Kath, Michael T. Gee, Paulo W. Pires   +8 more
wiley   +1 more source

Sodium Alginate - Gelatin Cross-Linked Microspheres for Releasing Diltiazem Hcl

Science Journal of University of Zakho, 2016
Semi-interpenetrating polymer network (semi-IPN) microspheres of Sodium alginate (NaAlg) and Gelatin were prepared and cross-linked with glutaraldehyde by using emulsification/solvent-evaporation method to deliver Diltiazem HCl as a model of drug ...
Alarqam Z. Tareq, Mohammed S. Hussein
doaj  

Part 2: Drug Interactions Involving Cannabis Products in Persons Aged 18 and Over: A Summary of Published Case Reports and Analysis of the FDA Adverse Event Reporting System

Pharmacology Research &Perspectives, Volume 13, Issue 1, February 2025.
ABSTRACT The increasing utilization of cannabis products combined with lack of data regarding potential cannabis–prescription drug interactions is concerning. This study aimed to review published case reports and FDA Adverse Event Reporting System (FAERS) spontaneous reports to assess cannabis–drug interactions in persons aged 18 and over. A literature
Maryann R. Chapin, Sandra L. Kane‐Gill, Xiaotong Li, Kojo Abanyie, Sanya B. Taneja, Susan Egbert, Mary F. Paine, Richard D. Boyce   +7 more
wiley   +1 more source

Biodegradable microparticulate drug delivery system of diltiazem HCl

Brazilian Journal of Pharmaceutical Sciences, 2012
The efficacy of a drug in a specific application requires the maintenance of appropriate drug blood level concentration during a prolonged period of time.
Manish Kumar Gupta, Deepak Prakash, Brahmeshwar Mishra   +2 more
doaj  

Standard Protocols for Characterising Primary and In Vitro‐Generated Human Hepatocytes

Journal of Cellular and Molecular Medicine, Volume 29, Issue 3, February 2025.
ABSTRACT Hepatocyte‐like cells (HLCs) derived from pluripotent stem cells (PSCs) or direct reprogramming are an unlimited source of human hepatocytes for biomedical applications. HLCs are used to model human diseases, develop precise drugs and establish groundbreaking regenerative cell‐based therapies.
Zahra Heydari, Roberto Gramignoli, Abbas Piryaei, Ensieh Zahmatkesh, Paria Pooyan, Homeyra Seydi, Andreas Nussler, Dagmara Szkolnicka, Hassan Rashidi, Mustapha Najimi, David C. Hay, Massoud Vosough   +11 more
wiley   +1 more source

Inhibition of diacylglycerol lipase α induced blood–brain barrier breach in female Sprague–Dawley rats

The Journal of Physiology, Volume 603, Issue 4, Page 929-947, 15 February 2025.
Abstract figure legend This study demonstrated that intraperitoneal administration of the diacylglycerol lipase α (DAGLα) inhibitor, LEI‐106, causes blood–brain barrier (BBB) disruption manifesting as increased [14C]sucrose uptake in in situ brain perfusion experiments.
Erika Liktor‐Busa, Aidan A. Levine, Sally J. Young, Colin Bader, Seph M. Palomino, Felipe D. Polk, Sarah A. Couture, Paulo W. Pires, Trent Anderson, Tally M. Largent‐Milnes   +9 more
wiley   +1 more source

In vitro Assessment of the Adsorption Efficacy of Activated Charcoal versus Kaolin on some used Medications of Narrow Index of Safety

Iraqi Journal of Pharmaceutical Sciences
The purpose of this study is to investigate the in vitro adsorption power of activated charcoal (AC), light kaolin (LK), and heavy kaolin (HK) at a concentration of 0.2% weight-per-volume (w/v) on high dosages (10 tablets) of a variety of medications ...
Asmaa Abdelaziz Mohamed, Firas Aziz Rahi, Amna F. Alberqdar, Teeba Abdellatif Aziz   +3 more
doaj   +1 more source

Calcium Channel Blocker Lacidipine Promotes Antitumor Immunity by Reprogramming Tryptophan Metabolism

Advanced Science, Volume 12, Issue 3, January 20, 2025.
The antihypertensive drug lacidipine, as a bifunctional modulator of the enzymatic activity and expression of indoleamine 2,3‐dioxygenase 1 (IDO1), targets calcium channels to inhibit (Protein Tyrosine 2 (Pyk2)‐Janus Kinase 1 (JAK1)‐calmodulin complex‐mediated IDO1 immunosuppression.
Yuwen Sheng, Chong Qiao, Zhonghui Zhang, Xiaoke Shi, Linhan Yang, Ruiying Xi, Jialing Yu, Wanli Liu, Guolin Zhang, Fei Wang   +9 more
wiley   +1 more source

Impact of a Green Cabbage‐Based Diet on Selected Proinflammatory Cytokines and Hormones in Pre‐Eclamptic Rats

Journal of Food Biochemistry, Volume 2025, Issue 1, 2025.
The growing interest in functional foods has led to the utilization of various vegetables for their nutritional benefits. This study focused on the development and evaluation of a green cabbage‐enriched meal and the investigation of the impact of the enriched cookies on selected proinflammatory cytokines and hormones in pre‐eclamptic Wistar rats.
Omolola Mary Omosebi, Fehintoluwa Joy Femi-Olabisi, Jesukorede Chisom Aluko, Vijay Singh Sharanagat   +3 more
wiley   +1 more source

Tools for clinical pharmacists to identify medications that can cause drug‐induced cognitive impairment: A systematic review

JACCP: JOURNAL OF THE AMERICAN COLLEGE OF CLINICAL PHARMACY, Volume 7, Issue 12, Page 1207-1227, December 2024.
Abstract Cognitive impairment affects around 19% of community‐dwelling older adults in the United States. Pharmacists can play a significant role in identifying and deprescribing cognitive‐impairing medications through cognitive‐focused medication reviews or as part of comprehensive medication management.
Jacob Stanton, Michael R. Gionfriddo, Gail B. Rattinger, Yuan Fang, Mia E. Lussier   +4 more
wiley   +1 more source