Results 41 to 50 of about 1,208 (130)

Thinking Three‐Dimensionally: A Self‐ and Externally‐Controlled Approach to Screening for Drug–Drug–Drug Interactions Among High‐Risk Populations

Clinical Pharmacology &Therapeutics, Volume 116, Issue 2, Page 448-459, August 2024.
The global rise in polypharmacy has increased both the necessity and complexity of drug–drug interaction (DDI) assessments, given the growing potential for interactions involving more than two drugs. Leveraging large‐scale healthcare claims data, we piloted a semi‐automated, high‐throughput case‐crossover‐based approach for drug–drug–drug interaction ...
Emily K. Acton, Sean Hennessy, Michael A. Gelfand, Charles E. Leonard, Warren B. Bilker, Di Shu, Allison W. Willis, Scott E. Kasner   +7 more
wiley   +1 more source

A Validated UV Spectroscopic method for Quantification of Lidocaine HCl and Diltiazem HCl

A Simple and routinely used UV- Spectroscopic technique has been developed for estimating Lidocaine hydrochloride and Diltiazem hydrochloride in bulk and combined dosage form. The simultaneous estimation using first- order derivative analysis was 0.1 M HCl solvent, with scanning at wavelengths of 223 nm and 250 nm for quantifying lidocaine HCl and ...
Nirali Chaudhari, Sanika Saskshee, Shruti Patel, Jay Chandwani, Heta Kachhiya   +4 more
openaire   +2 more sources

The Tissue‐Specific Eco‐Exposome: Differential Pharmaceutical Bioaccumulation and Disposition in Fish among Trophic Positions

Environmental Toxicology and Chemistry, Volume 43, Issue 8, Page 1894-1902, August 2024.
Abstract Though bioaccumulation of pharmaceuticals by aquatic organisms continues to receive scientific attention, the internal disposition of these contaminants among different tissue compartments of fish species has been infrequently investigated, particularly among fish at different trophic positions. We tested a human to fish biological read‐across
Jaylen L. Sims, Alexander R. Cole, Zachary S. Moran, Charles M. Mansfield, Bianca Possamai, Macarena Rojo, Ryan S. King, Cole W. Matson, Bryan W. Brooks   +8 more
wiley   +1 more source

Pharmacokinetics and Pharmacodynamics of Etripamil, an Intranasally Administered, Fast‐Acting, Nondihydropyridine Calcium Channel Blocker

Clinical Pharmacology in Drug Development, Volume 13, Issue 4, Page 367-379, April 2024.
Abstract Etripamil, a fast‐acting nondihydropyridine L‐type calcium channel blocker, is under investigation for potential self‐administration for the acute treatment of supraventricular tachyarrhythmias in a medically unsupervised setting. We report detailed pharmacokinetics and pharmacodynamics of intranasally administered etripamil in healthy adults ...
James E. Ip, Douglas Wight, Corinne Seng Yue, David Nguyen, Francis Plat, Bruce S. Stambler   +5 more
wiley   +1 more source

TRPV4 promotes HBV replication and capsid assembly via methylation modification of H3K4 and HBc ubiquitin

Journal of Medical Virology, Volume 96, Issue 4, April 2024.
Abstract Hepatitis B virus (HBV) infection poses a significant burden on global public health. Unfortunately, current treatments cannot fully alleviate this burden as they have limited effect on the transcriptional activity of the tenacious covalently closed circular DNA (cccDNA) responsible for viral persistence.
Yu Zhang, Xiaoxue Yuan, Jun Wang, Ming Han, Hongping Lu, Yun Wang, Shunai Liu, Song Yang, Hui‐Chun Xing, Jun Cheng   +9 more
wiley   +1 more source

FORMULATION AND IN VITRO EVALUATION OF CONTROLLED RELEASE MATRIX TABLETS OF DILTIAZEM HCL

, 2023
The present study involves in the formulation and evaluation of Controlled release tablets of Diltiazem HCl (100mg). The objective of the present study was to formulate Diltiazem hcl Controlled release tablets by Direct compression method by using HPMC K 15M, HPC 2M and HEC 2M.
openaire   +2 more sources

Phenotypic Screening of Prospective Analgesics Among FDA‐Approved Compounds using an iPSC‐Based Model of Acute and Chronic Inflammatory Nociception

Advanced Science, Volume 11, Issue 11, March 20, 2024.
Chronic pain remains the number one public health crisis in the US and around the world. Phenotypic screening assays for identifying novel analgesics are desperately needed. Here, the authors report on the development and characterization of an inflammatory nociception screening assay based on spontaneous and evoked activity from human induced ...
Bryan James Black, Rasha El Ghazal, Neal Lojek, Victoria Williams, Jai Singh Rajput, Jennifer M. Lawson   +5 more
wiley   +1 more source

Design And Evaluation Of Bilayer Floating Tablets Of Diltiazem Hcl

, 2017
The present investigation concerns design and evaluation of bilayer floating tablets of Diltiazem HCl Diltiazem HCl is Class I drug, though its reported bioavailability is only 40 %. It is having very short half life of 3 to 4 hrs. Hence many sustained release formulations were developed for Diltiazem HCl.
openaire   +2 more sources

Drug release evaluation of Diltiazem HCl CR preparations [PDF]

Journal of Pharmacy and Pharmacology, 1998
Anurag Sood, Ramesh Panchagnula
openaire   +1 more source

Sophisticated Planar Chromatographic Method Estimation and Validation for Newer Combination of Lidocaine HCl and Diltiazem HCl For Anal Fissure

Abstract Newer drugs and drugs combinations for treatment of different diseases are approved by regulatory authorities. Such new combination of existing drugs like Lidocaine HCl and Diltiazem HCl has been approved for anal fissure treatment. The present study represents validated method for estimation of Lidocaine HCl and Diltiazem HCl in a ...
Maitri Shah, Hetaben Kachhiya, Jinal Tandel, Usmangani Chhalotiya, Dimal Shah, Adarsh Patelia, Mehul Patel   +6 more
openaire   +1 more source