Results 41 to 50 of about 4,480 (170)

Removal of pharmaceuticals in WWTP effluents by ozone and hydrogen peroxide [PDF]

, 2014
Ozonation to achieve removal of pharmaceuticals from wastewater effluents, with pH values in the upper and lower regions of the typical range for Swedish wastewater, was investigated.
Andersen, H. R., Fick, J., Hey, Gerly,, la Cour Jansen, Jes,, Ledin, A., Lund University., Tysklind, M., Vega, S. R.   +7 more
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Novel 5-oxo-hexahydroquinoline derivatives: design, synthesis, in vitro P-glycoprotein-mediated multidrug resistance reversal profile and molecular dynamics simulation study [PDF]

, 2017
Overexpression of the efflux pump P-glycoprotein (P-gp) is one of the important mechanisms of multidrug resistance (MDR) in many tumor cells. In this study, 26 novel 5-oxo-hexahydroquinoline derivatives containing different nitrophenyl moieties at C-4 ...
Edraki, N., Firuzi, O., Khoshneviszadeh, M., Miri, R., Ranjbar, S., Saso, L., Shahraki, O., Zargari, F.   +7 more
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Preparation of modified release diltiazem HCl capsule by complexation with ion exchange resin [PDF]

Iraqi Journal of Pharmacy, 2011
Background: Diltiazem HCl is a calcium channel blocker drug used in the treatment of angina pectoris and hypertension. Objective: To prepare a sustained release diltiazem HCl capsule by complexation with polystyrene sulfonate strong cation exchange resin (dowex®50wx4) as a complexing and retarding agent.
Eman B.H. Al-Khedairy, Alaa A. Abdulrasso, Jenan M. AL-Mosawi   +2 more
openaire   +2 more sources

Evaluations of the effect of sodium metabisulfite on the stability and dissolution rates of various model drugs from the extended release polyethylene oxide matrices [PDF]

, 2017
Purpose: This study examines the effect of sodium metabisulfite (SMB) as an antioxidant on the stability and release of various model drugs namely propranolol HCl, theophylline and zonisamide from the polyethylene oxide (PEO) tablets. The antioxidant was
Ali Nokhodchi, AR Rajabi-Siahboomi, AR Rajabi-Siahboomi, C Maderuelo, CJ Kim, CJ Kim, D Kiss, G Gallet Guillaume, GM Khan, H Lapidus, H Li, JW Moore, KA Khan, L Hongtao, L Maggi, L Maggi, L Yang, M Dimitrov, M Rane, MA Khan, Mohammed Maniruzzaman, MZ Khan, P Colombo, PI Lee, PI Lee, RC Rowe, RW Korsmeyer, S Shojaee, Saeed Shojaee, SS Davis, X Huang   +30 more
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Evaluation of sesamum gum as an excipient in matrix tablets [PDF]

, 2016
In developing countries modern medicines are often beyond the affordability of the majority of the population. This is due to the reliance on expensive imported raw materials despite the abundance of natural resources which could provide an equivalent or
Akpabio, E., Jackson, C., Ubulom, P., Adedokun, M., Umoh, R., Ugwu, C., Al-Hamidi, H., Asare-Addo, K., Desai, S., Kitson, M., & Nokhodchi, A., Al-Hamidi, H., Edwards, A.A., Douroumis, D., Asare-Addo, K., Nayebi, A.M., Reyhani-Rad, S., Mahmoudi, J., Nokhodchi, A., Allagh, T.S., Meseke, A., Ibrahim, Y.K.E., Aoki, S., Ando, H., Ishii, M., Watanabe, S., & Ozawa, H., Asare-Addo, K., Conway, B. R., Hajamohaideen, M. J., Kaialy, W., Nokhodchi, A., & Larhrib, H., Asare-Addo, K., Levina, M., Rajabi-Siahboomi, A.R., Nokhodchi, A., Asare-Addo, K., Levina, M., Rajabi-Siahboomi, A.R., Nokhodchi, A., Asare-Addo, K., Šupuk, E., Al-Hamidi, H., Owusu-Ware, S., Nokhodchi, A., & Conway, B. R., Bamba, M., Puisieux, F., Marty, J.P., Carstensen, J.T., Bonferoni, M.C., Rossi, S., Tamayo, M., Pedraz, J.L., Dominguez-Gil, A., Caramella, C., Colombo, P., Bettini, R., Massimo, G., Catellani, P.L., Santi, P., Peppas, N.A., Cox, P.J., Khan, K.A., Munday, D.L., Sujja-areevath, J., Ghori, M. U., Ginting, G., Smith, A. M., & Conway, B. R., Gohel, M., Parikh, R., Nagori, S., Jena, D., Harland, R.S., Gazzaniga, A., Sangalli, M.E., Colombo, P., Peppas, N.A., Heckel, R.W., Heckel, R.W., Heller, J., Helwing, R.F., Baker, R.W., Tuttle, M.E., Hixson, A.W. and Crowell, J.H., Huang, X., Brazel, C., Jackson, C., Akpabio, E., Umoh, R., Adedokun, M., Ubulom, P and Ekpe, G., Kaialy W, Emami P, Asare-Addo K, Shojaee S, Nokhodchi A., Kavanagh, N., & Corrigan, O. I., Khan, K.A., Khullar, P., Khar, R.K., Agarwal, S.P., Korsmeyer, R.W., Gurny, R., Docler, E., Buri, P., Peppas, N.A., Kristmundsdóttir, T., Ingvarsdóttir, K., Sæmundsdóttir, G., Lee, P.I., Kim, C.J., Leuenberger, H., Melia, C.D., Moore, J.W., Flanner, H.H., Mu, X., Tobyn, M.J., Staniforth, J.N., Naggar, V.F., El-Khawas, M., Ismail, F.A., Boraie, N.A., Nep, E. I. & Conway, B. R., Nep, E. I., Sims, I. M., Morris, G. A., Kontogiorgos, V., & Smith, A. M., Nokhodchi, A., & Asare-Addo, K., Nokhodchi, A., Raja, S., Patel, P., & Asare-Addo, K., Panomsuk, S.P., Hatanaka, T., Aiba, T., Katayama, K., Koizumi, T., Peppas, N.A., Sahlin, J.J., Pillay, V., & Fassihi, R., Polli, J. E., Yu, L. X., Cook, J. A., Amidon, G. L., Borchardt, R. T., Burnside, B. A., et al., Polli, J.E., Rekhi, G.S., Augsburger, L.L., Shah, V.P., Reynolds, T.D., Gehrke, S.H., Hussain, A.S., Shenouda, L.S., Ritger, P.L. and Peppas, N.A., Shojaee, S., Asare-Addo, K., Kaialy, W., Nokhodchi, A., & Cumming, I., Siahi-Shadbad, M. R., Asare-Addo, K., Azizian, K., Hassanzadeh, D. & Nokhodchi, A., Siepmann, J., Peppas, N.A., Sriamornsak, P., Thirawong, N., Korkerd, K., Sujja-areevath, J., Munday, D.L., Cox, P.J., Khan, K.A., Sujja-areevath, J., Munday, D.L., Cox, P.J., Khan, K.A., Tahara, K., Yamamoto, K., Nishihata, T., Talukdar, M.M., Michoel, A., Rombaut, P., Kinget, R., Tiwari, S. B., & Rajabi-Siahboomi, A. R., Tiwari, S.B., Murthy, T.K., Pai, M.R., Mehta, P.R., Chowdary, P.B., Vervoort, L., Van den Mooter, G., Augustijns, P., Kinget, R.   +55 more
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Vegetable Oil‐Based Materials for Drug Delivery Systems and Wound Dressings

Macromolecular Bioscience, Volume 26, Issue 3, March 2026.
Renewable resources like vegetable oils are increasingly explored for biomaterial production in biomedical applications. Their monoglycerides and triglycerides inherently possess functions or can be chemically modified to introduce functional groups suitable for polymerization, yielding biomaterials with desirable properties such as flexibility ...
Lucas M. Favre, Nicolas Masurier, Anne Aubert‐Pouëssel   +2 more
wiley   +1 more source

A Facile Protocol for C(sp2)–C(sp3) Bond Formation Reactions Toward Functionalized E3 Ligase Ligands

ChemMedChem, Volume 21, Issue 4, 25 February 2026.
A robust C(sp2)–C(sp3) decarboxylative coupling strategy enables access to new CRBN ligands and degraders with improved physicochemical properties. This synthetic approach is expanding the chemical space beyond C(sp2)–N linkages, fine‐tuning proteolysis‐targeting chimera activities and unlocking previously inaccessible degrader chemotypes.
Anita Maksutova, Thomas M. Geiger, Lorenzo Cianni, Dominika E. Pieńkowska, Jan Gerhartz, Lina Read, Aleša Bricelj, Alexander Herrmann, Maurice Leon Nelles, Yuen Lam Dora Ng, Marcus D. Hartmann, Jan Krönke, Izidor Sosič, Radosław P. Nowak, Michael Gütschow, Christian Steinebach   +15 more
wiley   +1 more source

The evaluation of Eudragit microcapsules manufactured by solvent evaporation using USP Apparatus 1 [PDF]

, 2009
The objectives of this study were to prepare microcapsules containing verapamil and propranolol and to evaluate the kinetics and mechanism of drug release from the microcapsules using USP Apparatus 1. The effects of polymer concentration and polymer type
Haidula, H, Khamanga, S M M, Nyamuzhiwa, T, Parfitt, N, Walker, Roderick   +4 more
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Development and Validation of Quality by Design‐Based HPLC Method for Impurity Profiling of Alprazolam

SEPARATION SCIENCE PLUS, Volume 8, Issue 10, October 2025.
ABSTRACT A quality by design (QbD)‐aided stability‐indicating method was developed for the simultaneous quantification of alprazolam and its four impurities using HPLC. The method was systematically optimized, followed by the establishment of a “method operable design region (MODR).” Critical parameters and ICH (Q14) emphasize the adherence to a “low ...
Mahesh Napa, Venkata Ratnam K., Venkata Nadh Ratnakaram, Sunil Dhuri, Bondigalla Ramachandra   +4 more
wiley   +1 more source

Optimasi Tepung Lidah Buaya (Aloe Vera L.) Dan Carbopol 934p Sebagai Mucoadhesive Agent Pada Sediaan Mikrogranul Ranitidin Hcl Secara Simplex Lattice Design [PDF]

, 2017
Ranitidin Hidroklorida merupakan antagonis reseptor histamin H2 secara selektif dan reversible dengan waktu paruh yang pendek yaitu 2,5-3 jam, sehingga perlu dikembangkan sediaan lepas lambat dalam bentuk mucoadhesive.
Cahyani, R. H. (Revita)
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