Results 51 to 60 of about 4,480 (170)

Sex‐specific mechanisms of cerebral microvascular BKCa dysfunction in a mouse model of Alzheimer's disease

Alzheimer's &Dementia, Volume 21, Issue 2, February 2025.
Abstract INTRODUCTION Cerebrovascular dysfunction occurs in Alzheimer's disease (AD), impairing hemodynamic regulation. Large conductance Ca2+‐activated K+ channels (BKCa) regulate cerebrovascular reactivity and are impaired in AD. BKCa activity depends on intracellular Ca2+ (Ca2+ sparks) and nitro‐oxidative post‐translational modifications.
Josiane F. Silva, Felipe D. Polk, Paige E. Martin, Stephenie H. Thai, Andrea Savu, Matthew Gonzales, Allison M. Kath, Michael T. Gee, Paulo W. Pires   +8 more
wiley   +1 more source

Evaluation of the drug solubility and rush ageing on drug release performance of various model drugs from the modified release polyethylene oxide matrix tablets [PDF]

, 2017
Hydrophilic matrix systems are currently some of the most widely used drug delivery systems for controlled-release oral dosage forms. Amongst a variety of polymers, polyethylene oxide (PEO) is considered an important material used in pharmaceutical ...
A Miranda, AG Thombre, BJ Lee, CJ Kim, D Kiss, EM Yasser, H Lapidus, J Gaston, J Petrovi’c, K Cho, K Pielichowski, KA Khan, L Liu, L Maggie, L Yang, M Dimitrov, M Efentakis, M Rane, MA Khan, MA Longer, MM Crowley, MO Emeji, N Sarisuta, P Roy, PD Haan, PS Heng, S Engineer, S Shojaee, S Shojaee, SW Bigger, USP Pharmacopoeia 26, Y Malah   +31 more
core   +1 more source

Part 2: Drug Interactions Involving Cannabis Products in Persons Aged 18 and Over: A Summary of Published Case Reports and Analysis of the FDA Adverse Event Reporting System

Pharmacology Research &Perspectives, Volume 13, Issue 1, February 2025.
ABSTRACT The increasing utilization of cannabis products combined with lack of data regarding potential cannabis–prescription drug interactions is concerning. This study aimed to review published case reports and FDA Adverse Event Reporting System (FAERS) spontaneous reports to assess cannabis–drug interactions in persons aged 18 and over. A literature
Maryann R. Chapin, Sandra L. Kane‐Gill, Xiaotong Li, Kojo Abanyie, Sanya B. Taneja, Susan Egbert, Mary F. Paine, Richard D. Boyce   +7 more
wiley   +1 more source

Role of CA2+/calmodulin on ethanol neurobehavioral effects [PDF]

, 2014
Rationale. The cAMP-dependent protein kinase A (PKA) signaling transduction pathway has been shown to play an important role in the modulation of several ethanol-induced behaviors.
Baliño, Pablo, González Aragón, Carlos Manuel, Ledesma Llorente, Juan Carlos   +2 more
core   +1 more source

Standard Protocols for Characterising Primary and In Vitro‐Generated Human Hepatocytes

Journal of Cellular and Molecular Medicine, Volume 29, Issue 3, February 2025.
ABSTRACT Hepatocyte‐like cells (HLCs) derived from pluripotent stem cells (PSCs) or direct reprogramming are an unlimited source of human hepatocytes for biomedical applications. HLCs are used to model human diseases, develop precise drugs and establish groundbreaking regenerative cell‐based therapies.
Zahra Heydari, Roberto Gramignoli, Abbas Piryaei, Ensieh Zahmatkesh, Paria Pooyan, Homeyra Seydi, Andreas Nussler, Dagmara Szkolnicka, Hassan Rashidi, Mustapha Najimi, David C. Hay, Massoud Vosough   +11 more
wiley   +1 more source

In vitro Assessment of the Adsorption Efficacy of Activated Charcoal versus Kaolin on some used Medications of Narrow Index of Safety

Iraqi Journal of Pharmaceutical Sciences
The purpose of this study is to investigate the in vitro adsorption power of activated charcoal (AC), light kaolin (LK), and heavy kaolin (HK) at a concentration of 0.2% weight-per-volume (w/v) on high dosages (10 tablets) of a variety of medications ...
Asmaa Abdelaziz Mohamed, Firas Aziz Rahi, Amna F. Alberqdar, Teeba Abdellatif Aziz   +3 more
doaj   +1 more source

Identifikasi Potensi Interaksi Obat Pada Pasien Rawat Inap Penyakit Dalam Di RSUD Dr. Moewardi Tahun 2014 [PDF]

, 2016
Patients with internal diseases are usually treated by a combination of more than two drugs that causes potential drug interactions. Patients who suffer from the internal disease usually suffer from more than one disease.
, Dra. Nurul Mutmainah, M.Si., Apt, Widyaningrum, Ristia   +1 more
core  

Inhibition of diacylglycerol lipase α induced blood–brain barrier breach in female Sprague–Dawley rats

The Journal of Physiology, Volume 603, Issue 4, Page 929-947, 15 February 2025.
Abstract figure legend This study demonstrated that intraperitoneal administration of the diacylglycerol lipase α (DAGLα) inhibitor, LEI‐106, causes blood–brain barrier (BBB) disruption manifesting as increased [14C]sucrose uptake in in situ brain perfusion experiments.
Erika Liktor‐Busa, Aidan A. Levine, Sally J. Young, Colin Bader, Seph M. Palomino, Felipe D. Polk, Sarah A. Couture, Paulo W. Pires, Trent Anderson, Tally M. Largent‐Milnes   +9 more
wiley   +1 more source

The impact of fish oil fatty-acids on post-prandial vascular reactivity. [PDF]

, 2014
Progressive loss of vascular reactivity and increased vascular tone with age are being increasingly recognised as significant cardiovascular disease (CVD) risk factors.
Mcmanus, Sean
core  

Calcium Channel Blocker Lacidipine Promotes Antitumor Immunity by Reprogramming Tryptophan Metabolism

Advanced Science, Volume 12, Issue 3, January 20, 2025.
The antihypertensive drug lacidipine, as a bifunctional modulator of the enzymatic activity and expression of indoleamine 2,3‐dioxygenase 1 (IDO1), targets calcium channels to inhibit (Protein Tyrosine 2 (Pyk2)‐Janus Kinase 1 (JAK1)‐calmodulin complex‐mediated IDO1 immunosuppression.
Yuwen Sheng, Chong Qiao, Zhonghui Zhang, Xiaoke Shi, Linhan Yang, Ruiying Xi, Jialing Yu, Wanli Liu, Guolin Zhang, Fei Wang   +9 more
wiley   +1 more source