Results 101 to 110 of about 2,092,591 (384)

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Persistence in the Zero-Temperature Dynamics of the Diluted Ising Ferromagnet in Two Dimensions

, 1999
The non-equilibrium dynamics of the strongly diluted random-bond Ising model in two-dimensions (2d) is investigated numerically. The persistence probability, P(t), of spins which do not flip by time t is found to decay to a non-zero, dilution-dependent,
A. J. Bray, B. Derrida, B. Derrida, B. Derrida, B. Derrida, B. Zheng, C. M. Newman, D. Stauffer, K. Oerding, S. Jain, S. Jain, S. N. Majumdar   +11 more
core   +2 more sources

Diluted Josephson-junction arrays in a magnetic field: phase coherence and vortex glass thresholds [PDF]

, 1998
The effects of random dilution of junctions on a two-dimensional Josephson-junction array in a magnetic field are considered. For rational values of the average flux quantum per plaquette $f$, the superconducting transition temperature vanishes, for ...
A. J. Bray, A.-L. Eichenberger, C. Dekker, C. Wengel, D. B. Nicolides, D. C. Harris, D. S. Fisher, D. Stauffer, E. Granato, E. Granato, E. Granato, Enzo Granato, HJ. Xu, J. Adler, J. Maucourt, M. Cieplak, Marc Gabay, Mourad Benakli, N. Kawashima, P. Gawiec, R. A. Hyman, S. John, S. R. Shenoy, S. R. Shenoy, S. Teitel, Subodh R. Shenoy, T. Giamarchi, W. Selke, X. C. Zeng   +28 more
core   +2 more sources

The anticancer effect of the HDAC inhibitor belinostat is enhanced by inhibitors of Bcl‐xL or Mcl‐1 in ovarian cancer

Molecular Oncology, EarlyView.
The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine, Sterenn Guillemot, Louis‐Bastien Weiswald, Romane Florent, Edwige Abeilard, Florence Giffard, Emilie Brotin, Mélanie Briand, Enora Dolivet, Laurent Poulain, Marie Villedieu   +10 more
wiley   +1 more source

Clamp-tapering increases the quality factor of stressed nanobeams

, 2019
Stressed nanomechanical resonators are known to have exceptionally high quality factors ($Q$) due to the dilution of intrinsic dissipation by stress. Typically, the amount of dissipation dilution and thus the resonator $Q$ is limited by the high mode ...
Beccari, Alberto, Bereyhi, Mohammad J., Engelsen, Nils J., Fedorov, Sergey A., Ghadimi, Amir H., Kippenberg, Tobias J., Schilling, Ryan, Wilson, Dalziel J.   +7 more
core   +2 more sources

Types of infringement of a right to trade marks with reputation in Polish and EU jurisprudence

Eastern European Journal of Transnational Relations
This article aims at examining the extent to which the Polish and European Union adjudication bodies apply the EUCJ guidelines regarding determination of each type of the right to a trade mark with reputation (TMwR) infringement. The author analyses and
Joanna Sitko
doaj   +1 more source

Dose‐dependent induction of epithelial‐mesenchymal transition in 3D melanoma models by non‐thermal plasma treatment

Molecular Oncology, EarlyView.
Non‐thermal plasma treatment of melanoma cells induced epithelial‐mesenchymal transition (EMT) in a dose‐dependent fashion. This report highlights the critical need to further investigate potential adverse effects of non‐thermal plasma for cancer therapy and to optimize treatment parameters for clinical translation. Despite the promising results of non‐
Eline Biscop, Edgar Cardenas De La Hoz, Hanne Verswyvel, Joey De Backer, Ho Wa Lau, Angela Privat‐Maldonado, Wim Vanden Berghe, Steve Vanlanduit, Evelien Smits, Annemie Bogaerts, Abraham Lin   +10 more
wiley   +1 more source

Phase boundary detection for dilution refrigerators

, 2004
We describe a device to conveniently measure the positions of the phase boundaries in a dilution refrigerator. We show how a simple modification of a standard capacitive level gauge (segmentation of one of the electrodes) permits a direct calibration of ...
Martin, R. V., ter Haar, E.
core   +1 more source

The Fate of the Universe: Dark Energy Dilution? [PDF]

, 2007
We study the possibility that dark energy decays in the future and the universe stops accelerating. The fact thatthe cosmological observations prefer an equation of state of dark energy smaller than -1 can be a signal that dark energy will decay in the ...
de la Macorra, A.
core   +2 more sources

Molecular imaging predicts trastuzumab‐deruxtecan (T‐DXd) response in head and neck cancer xenograft models

Molecular Oncology, EarlyView.
Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed, Lucas Mani, Muhammad Bilal Mirza, Ashtyn McAdoo, Takahito Kondo, Hidenori Tanaka, Nicole Meeks, Eben Rosenthal, Marisa Hom   +8 more
wiley   +1 more source