Results 61 to 70 of about 247,874 (214)
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells
FEBS Open Bio, EarlyView.To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai +8 more
wiley +1 more source
Dimensión social de la gestión de operaciones aeroportuarias
Santiago, 2023 El aeropuerto es un sistema complejo y dinámico dada la naturaleza de su actividad, con gran impacto social y económico. Con el uso de los métodos teóricos: análisis-síntesis e inducción-deducción, la revisión documental y de entrevistas informales a ...
Gretell Hartman-Romero +1 more
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FEBS Open Bio, EarlyView.The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley +1 more source
La dimensión social de la sexualidad
Estudios Eclesiásticos, 1981 El presente estudio aborda la dimensión social de la sexualidad, partiendo de la ética tradicional desde la función individual y social del sexo. Por otra parte, se analiza el influjo que la sociedad tiene en el comportamiento sexual, la importancia del ...
Eduardo López Azpitarte
doaj
Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids
FEBS Open Bio, EarlyView.Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão +3 more
wiley +1 more source
Pathways and pitfalls: a qualitative study of student experiences in biomedical science education
FEBS Open Bio, EarlyView.Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell +8 more
wiley +1 more source
La dimensión social de la empresa
Revista Empresa y Humanismo, 2008 La visión dominante de la empresa tiende a centrarse en la ganancia monetaria como única justificación social de la misma. En este artículo se considera necesaria esa condición, pero se ahonda en las condiciones sociales suficientes para considerar la ...
Javier Aranzadi del Cerro
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Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface
FEBS Open Bio, EarlyView.HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana +5 more
wiley +1 more source
LA DIMENSIÓN SOCIAL DEL APRENDIZAJE COLABORATIVO
RED. Revista de Educación a Distancia, 2007 El objetivo de este artículo es analizar la dimensión social de los grupos colaborativos virtuales. Aunque, a menudo, estos aspectos de carácter informal o afectivo se infravaloran o separan de los propios del aprendizaje, son muy numerosos los estudios ...
Maria Pérez +2 more
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