Results 81 to 90 of about 12,062,578 (239)

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

open access: yesFEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks   +4 more
wiley   +1 more source

La dimensión social de la sexualidad

open access: yesEstudios Eclesiásticos, 1981
El presente estudio aborda la dimensión social de la sexualidad, partiendo de la ética tradicional desde la función individual y social del sexo. Por otra parte, se analiza el influjo que la sociedad tiene en el comportamiento sexual, la importancia del ...
Eduardo López Azpitarte
doaj  

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

open access: yesFEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito   +7 more
wiley   +1 more source

Banco de dados de experiências bem-sucedidas em desenvolvimento social

open access: yes, 2010
Considerado en el Grupo de Trabajo sobre la Dimensión Social / Minuta 3 de fecha 12 de julio de 2010 y Minuta 4 del 20 de julio del mismo año.ALADI. Secretaría General.
ALADI. Secretaría General. Departamento de la Dimensión Social
core   +1 more source

La dimensión social de la empresa

open access: yesRevista Empresa y Humanismo, 2008
La visión dominante de la empresa tiende a centrarse en la ganancia monetaria como única justificación social de la misma. En este artículo se considera necesaria esa condición, pero se ahonda en las condiciones sociales suficientes para considerar la ...
Javier Aranzadi del Cerro
doaj  

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

open access: yesFEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

LA DIMENSIÓN SOCIAL DEL APRENDIZAJE COLABORATIVO

open access: yesRED. Revista de Educación a Distancia, 2007
El objetivo de este artículo es analizar la dimensión social de los grupos colaborativos virtuales. Aunque, a menudo, estos aspectos de carácter informal o afectivo se infravaloran o separan de los propios del aprendizaje, son muy numerosos los estudios ...
Maria Pérez   +2 more
doaj  

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

open access: yesFEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez   +6 more
wiley   +1 more source

Identifying and characterising a plant GH1 β‐glucosidase that exhibits hydrolytic activity on N‐linked glucopyranoside

open access: yesFEBS Open Bio, EarlyView.
We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli   +3 more
wiley   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

open access: yesFEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty   +13 more
wiley   +1 more source

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