Results 91 to 100 of about 4,820,978 (263)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

METHODS FOR INVESTIGATION OF CHEMICAL CHARACTERISTICS IN POLYMER MATERIALS

open access: yesНаука и техника, 2017
A method for measuring polymer chemical resistance by dipping specimens in chemical reagents is a standard investigation procedure used in chemical industry (Standards ASTM D543, ISO 155).
V. V. Kuzmich   +4 more
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

open access: yesFEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas   +3 more
wiley   +1 more source

The Effects of Dimensions on the Deformation Sensing Performance of Ionic Polymer-Metal Composites

open access: yesSensors, 2019
As an excellent transducer, ionic polymer-metal composites (IPMCs) can act as both an actuator and a sensor. During its sensing process, many factors, such as the water content, the cation type, the surface electrode, and the dimensions of the IPMC ...
Jiale Wang   +5 more
doaj   +1 more source

Pointwise dimensions and Rényi dimensions [PDF]

open access: yesProceedings of the American Mathematical Society, 2002
Summary: We prove that the local lower and upper pointwise dimensions of a probability measure \(\mu\) are bounded from below by the lower generalized dimension \({\underline D}_{\mu}(q)\) for \(q>1\) and from above by the upper generalized dimension \({\overline D}_{\mu}(q)\) for ...
openaire   +2 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Various polymerization temperature on dimensional accuracy of orthodontic acrylic base plate

open access: yesDental Journal, 2007
Cold curing acrylic is more porous, having more residual monomer and dimensional change. Physical property of cold curing acrylic shows to have very small dimensional change resulted from imperfect polymerization process and if dimensional change occurs,
Elly Rusdiana
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

open access: yesMolecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller   +17 more
wiley   +1 more source

A 27-Intersection Model for Representing Detailed Topological Relations between Spatial Objects in Two-Dimensional Space

open access: yesISPRS International Journal of Geo-Information, 2017
Determining the spatial relations between objects is a primary function of a geographic information system (GIS). One important aspect of spatial relations is topological relations, which remain constant under topological transformations.
Jingwei Shen, Tinggang Zhou, Min Chen
doaj   +1 more source

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