Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Effect of moisture content on terminal velocity of lentil grain
Research in Agricultural Engineering, 2019 One of the aerodynamic characteristics of lentil is its terminal velocity. In order to determinate the terminal velocity, was designed a vertical wind tunnel. It was fabricated based on existing methods and standards. For decreasing the non-uniformity of
Zahra Basati +2 more
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Front Matter (Cover, Note from the Editor, Table of Content)
Civil Engineering Dimension.
Civil Engineering Dimension
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Dimensions of Sustainability in Universities. Evolution. Instruments [PDF]
Ovidius University Annals: Economic Sciences Series, 2019 The notion is sustainable, it is suggested that it is well established at the level of the whole society, which is attributed to education, everything is very important, but the role of higher education is a clearly more important decisive statement ...
Adriana-Ioana Filip (Croitoru) +2 more
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Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Mechanochemical ammonia synthesis enhanced by silicon nitride as a defect-inducing physical promoter
Nature CommunicationsBy enabling ammonia synthesis under near ambient conditions, mechanochemistry provides a paradigm shift, a new decentralized production method that avoids the high temperature (above 400 °C) and high pressure (above 200 bar) requirements of the ...
Jae Seong Lee +11 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Computing Parameter Estimates of a Homogeneous Nested Piecewise Linear Regression
Вестник Дагестанского государственного технического университета: Технические наукиObjective. The aim of the study is to develop an algorithm for identifying the parameters of a homogeneous nested piecewise linear regression model of the first type by the method of least modules. Method.
S. I. Noskov, S. I. Belinskaya
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Investigating the Effects of Electromagnetic Fields and Dimensions on the Electronic Properties of Gallium Arsenide Nanowire with Aluminum-Gallium Arsenide Coating in The Presence of Spin-Orbit Interaction [PDF]
Journal of Optoelectronical NanostructuresIn this research, the interaction of electromagnetic fields and sizes on the energy levels and specific functions of a GaAs nanowire coated with, along with the spin-orbit effect, has been carefully investigated.
Alirteza Ghaffari
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