Results 61 to 70 of about 1,450,380 (307)
Nature CommunicationsAchieving precise stereocontrol when forging two vicinal C(sp³)–C bonds on unsymmetrical internal alkenes remains a formidable challenge. The comparable reactivity of alkyl radicals often compromises chemo- and regioselectivity, while the concurrent ...
Yanyan Zhang +7 more
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Inapproximability of VC Dimension and Littlestone's Dimension
CoRR, 2017 To appear in Conference On Learning Theory (COLT ...
Pasin Manurangsi, Aviad Rubinstein
openaire +3 more sources
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Ekonomika, 2005 When a foreign company enters Russia, it has plenty of choices for choosing a favourable location. A country with 17 million square kilometres, 33 cities with more than 0,5 million inhabitants and 89 different administrative regions contains a wide ...
Jari Jumpponen +2 more
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Nature CommunicationsMimicking biological systems’ sensing, learning, and memory capabilities in synthetic soft materials remains challenging. While significant progress has been made in sensory functions in ionogels, their learning and memory capabilities still lag behind ...
Ning Zhou +3 more
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Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
GiantThe field of polymer science has witnessed a paradigm shift from traditional polymers to giant molecules, which possess well-defined structures and discrete molecular weights. These giant molecules, constructed from precisely synthesized building blocks,
Hengzhi You +4 more
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Cartographie d’aujourd’hui et de demain : rappels et perspectives
Cybergeo, 2001 We start from the fact that each spatial object i is characterized by three coordinates: x (latitude), y (longitude) and z (by tradition elevation). The discussion proposed here turns around three axes: first, we remind some of the main problems when ...
Isabelle Thomas
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