Results 131 to 140 of about 281,586 (259)

A comparative evaluation of sufficient dimension reduction and traditional statistical methods for composite biomarker score construction in diagnostic classification. [PDF]

BMC Med Res Methodol
Ozen H, Colak E, Ozen D.
europepmc   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Contrastive dimension reduction: when and how? [PDF]

Adv Neural Inf Process Syst
Hawke S, Ma Y, Li D.
europepmc   +1 more source

Projection expectile regression for sufficient dimension reduction. [PDF]

Comput Stat Data Anal, 2023
Soale AN.
europepmc   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Assessing parameter identifiability of a hemodynamics PDE model using spectral surrogates and dimension reduction. [PDF]

PLoS Comput Biol
Colebank MJ.
europepmc   +1 more source

Similarity-assisted variational autoencoder for nonlinear dimension reduction with application to single-cell RNA sequencing data. [PDF]

BMC Bioinformatics, 2023
Kim G, Chun H.
europepmc   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Innovative Therapeutic Strategy for Complicated Thoracoabdominal Aortic Aneurysms: Dimension Reduction. [PDF]

JACC Case Rep
Wang S, Fu W, Wang L.
europepmc   +1 more source

Effects of dimension reduction of hyperspectral images in skin gross pathology. [PDF]

Skin Res Technol, 2023
Aloupogianni E, Ishikawa M, Ichimura T, Hamada M, Murakami T, Sasaki A, Nakamura K, Kobayashi N, Obi T.   +8 more
europepmc   +1 more source